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Tret 2020mg

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Promayer Health & Nutrition
Generic: Isotretinoin
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descriptionSafety Advices
Caution is advised when consuming alcohol with Tret 20. Please consult your doctor.
Tret 20 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effe... View More
Tret 20 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Tret 20 may cause side effects which could affect your ability to drive. Your night vision may get worse during your treatment. This can happen suddenly... View More
Tret 20 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Tret 20 may not be needed in th... View More
Tret 20 is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
descriptionMedical Overview


Tret 20 belongs to a group of medicines called retinoids, which are closely related to vitamin A derivative. It is used to treat severe acne that has no... View More

Uses of Tret 20

  • Acne

Side effects of Tret 20

  • Dry skin

How to use Tret 20

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tret 20 is to be taken wit... View More

How Tret 20 works

Tret 20 is a derivative of vitamin A. It acts on glands (sebaceous) to reduce the production of a natural substance (sebum) that causes acne. Also, the ... View More

What if you forget to take Tret 20?

If you miss a dose of Tret 20, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your r... View More

quick tipsQuick Tips
  • Take it with food.
  • Avoid exposure to sunlight while using Tret 20. Use protective measures such as sun-cream or protective clothing.
  • Avoid face waxing and laser treatment while using this medicine as it makes your skin more fragile.
  • Avoid taking tetracycline as it may reduce the Tret 20 activity.
  • Do not take Tret 20 if you are pregnant, planning pregnancy or breastfeeding.
  • It may cause dryness of mouth, lips, and eyes. Drink plenty of water, use moisturiser and avoid wearing contact lenses. Inform your doctor if it bothers... View More
descriptionBrief Description




Should be taken with food.

Adult Dose

Oral Severe, Recalcitrant Nodular Acne Severe nodular acne unresponsive to conventional therapy, including systemic antibiotics Adult: 0.5-1 mg/kg/da... View More

Child Dose

Severe, Recalcitrant Nodular Acne Severe nodular acne unresponsive to conventional therapy, including systemic antibiotics <12 years: Safety and effic... View More

Renal Dose

Renal impairment: Severe: Reduce initial dose (e.g. 10 mg daily), then gradually increase to 1 mg/kg as necessary.


Pregnancy, lactation.

Mode of Action

Isotretinoin is a synthetic retinoid which reduces sebaceous gland size and sebum production. It also regulates cell proliferation and differentiation.


Preexisting or predisposition to hypertriglyceridaemia (e.g. DM, obesity or increased alcohol intake). Monitor triglyceride levels. Monitor blood lipids... View More

Side Effect

>10% Cheilitis (90%),Xerosis,Xerostomia,Dry nose,Epistaxis,Pruritus,Conjunctivitis (including blepharoconjunctivitis) (40%),Irritation (40%),Increased ... View More


Additive toxicity with vitamin A or its derivatives. Decreased efficacy of microdosed progesterone (use 2 forms of contraception). May increase risk of ... View More


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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