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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Centoxin.
CONSULT YOUR DOCTOR
Centoxin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Centoxin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Centoxin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
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CAUTION
Centoxin should be used with caution in patients with kidney disease. Dose adjustment of Centoxin may be needed. Please consult your doctor.
Regular monitoring of kidney function tests, potassium, magnesium and calcium levels is advisable while you are taking this medicine.
SAFE IF PRESCRIBED
Centoxin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Centoxin may not be needed in these patients. Please consult your doctor.
Medicine Overview of Centoxin 0.05mg/ml Syrup
Introduction
Centoxin is a medicine used for the treatment of heart failure in combination with other medicines. It helps to provide symptomatic relief by making the heart pump blood more efficiently. This medicine is also used to treat abnormal heart rhythm (arrhythmia). Centoxin restores and maintains a normal and steady heartbeat. It should be taken regularly as advised by the doctor. You may take it with or without food but it is better to take this medicine at a fixed time. This medicine should not be stopped abruptly without consulting the doctor as this can worsen your condition. Regular follow-up with...
... Show moreUses of Centoxin
- Heart failure
- Arrhythmia
Side effects of Centoxin
Common
- Visual impairment
- Skin rash
- Nausea
- Vomiting
- Diarrhea
- Dizziness
- Arrhythmia (irregular heartbeats)
How to use Centoxin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Centoxin may be taken with or without food, but it is better to take it at a fixed time.
How Centoxin works
Centoxin is a cardiac glycoside. It works by correcting irregular heartbeat to a normal rhythm and increases the force with which the heart muscle contracts with every heartbeat. This makes the heart pump more efficiently and increases blood circulation throughout the body.
What if you forget to take Centoxin?
If you miss a dose of Centoxin, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Take Centoxin at the same time every day.
- Notify your doctor about other medicines you're taking to avoid drug interactions.
- Symptoms of overdose include slow heartbeat, dizziness, lightheadedness and breathing problems.
- Do not discontinue use without consulting your doctor even if you feel better. Stopping abruptly could worsen your condition.
Brief Description
Indication
Heart failure, Supraventricular arrhythmias, Atrial fibrillation and Atrial flutter
Administration
May be taken with or without food.
Adult Dose
Atrial Fibrillation Rapid digitalizing (loading-dose) regimen PO: 10-15 mcg/kg total loading dose; administer 50% initially; then may cautiously give 1/4 the loading dose q6-8hr twice; peform careful assessment of clinical response and toxicity before each dose Maintenance PO: 3.4-5.1 mcg/kg/day or 0.125-0.5 mg/day PO; may increase dose every 2 weeks based on clinical response, serum drug levels, and toxicity Heart Failure As per ACCF/AHA guidelines, a loading dose to initiate digoxin therapy in patients with heart failure is not necessary 0.125-0.25 mg PO/IV qDay; higher doses including 0.375-0.5 mg/day rarely needed Use lower end of dosing (0.125 mg/day) in patients...
... Show moreChild Dose
Heart Failure/Atrial Fibrillation Use doses at the lower end of the spectrm when treating heart failure Reduce dose by 20-25% when changing from oral formulation or IM to IV therapy Premature neonate PO: 1st loading dose, 10-15 mcg/kg; 2nd and 3rd loading doses, 5-7.5 mcg/kg q6-8hr for 2 doses; maintenance: 5-7.5 mcg/kg/day divided q12hr Full-term neonate PO: 1st loading dose, 12.5-17.5 mcg/kg; 2nd and 3rd loading doses, 6.25-8.75 mcg/kg q6-8hr for 2 doses; maintenance: 6-10 mcg/kg/day divided q12hr Infants & children 1-24 months PO: 1st loading dose, 17.5-30 mcg/kg; 2nd and 3rd loading doses, 8.75-15 mcg/kg q6-8hr for 2 doses;...
... Show moreRenal Dose
Use lower end of dosing (0.125 mg/day) in patients with impaired renal function
Contraindication
Digitalis toxicity, ventricular tachycardia/fibrillation, obstructive cardiomyopathy. Arrhythmias due to accessory pathways (e.g. Wolff-Parkinson-White syndrome).
Mode of Action
Digoxin is a cardiac glycoside which has positive inotropic activity characterized by an increase in the force of myocardial contraction. It also reduces the conductivity of the heart through the atrioventricular (AV) node. Digoxin also exerts direct action on vascular smooth muscle and indirect effects mediated primarily by the autonomic nervous system and an increase in vagal activity.
Precaution
Cardiac dysrhythmias, hypokalaemia, hypertension, IHD, hypercalcaemia, hypomagnesaemia, electroconversion, chronic cor pulmonale, aortic valve disease, acute myocarditis, congestive cardiomyopathies, constrictive pericarditis, heart block, elderly, renal impairment, abnormalities in thyroid function; pregnancy. IV digoxin can only be given to patients who have not received cardiac glycosides in the preceding 2 wk.
Lactation: Drug enters breast milk; use with caution (American Academy of Pediatrics committee states, "compatible with nursing")
Side Effect
1-10%
Dizziness (4.9%),Mental disturbances (4.1%),Diarrhea (3.2%),Headache (3.2%),Nausea (3.2%),Vomiting (1.6%),Maculopapular rash (1.6%)
<1%
Anorexia,Cardiac dysrhythmia,Arrhythmia in children (consider a toxicity)
Frequency Not Defined
Visual disturbance (blurred or yellow vision),Heart block (1°/2°/3°),Asystole,Tachycardia
Potentially Fatal: Cardiac arrhythmias in combination with heart block.
Pregnancy Category Note
Pregnancy Experience with digoxin in pregnant women over several decades, based on published retrospective clinical studies and case reports, has not led to the identification of a drug associated risk of major birth defects, miscarriage or adverse maternal and fetal outcomes Untreated underlying maternal conditions (eg, heart failure, atrial fibrillation) during pregnancy pose a risk to the mother and fetus Clinical considerations Pregnant women with heart failure are at increased risk for preterm birth; clinical classification of heart disease may worsen with pregnancy and lead to maternal or fetal death Pregnant women with atrial fibrillation are at an increased risk...
... Show moreInteraction
Effectiveness reduced by phenytoin, neomycin, sulphasalazine, kaolin, pectin, antacids and in patients receiving radiotherapy. Metoclopramide may alter the absorption of solid dosage forms of digoxin. Blood levels increased by calcium channel blockers, spironolactone, quinidine and calcium salts.
Potentially Fatal: Electrolyte imbalances such as hypokalaemia and hypomagnesemia (e.g. admin of potassium-losing diuretics, corticosteroids) can increase the risk of cardiac toxicity.
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