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Cetaxim 250
Globe Pharmaceuticals Ltd.
Generic: Cefotaxime
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Cetaxim 250 does not cause any harmful side effects.
SAFE IF PRESCRIBED
Cetaxim 250 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Cetaxim 250 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoid prolonged use of Cetaxim 250, since it may have possible effects such as rash and diarrhea.
UNSAFE
Cetaxim 250 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Cetaxim 250 should be used with caution in patients with kidney disease. Dose adjustment of Cetaxim 250 may be needed. Please consult your doctor.
Regular monitoring of kidney function may be advised while you are taking this medicine.
SAFE IF PRESCRIBED
Cetaxim 250 is safe to use in patients with liver disease. No dose adjustment of Cetaxim 250 is recommended.
Medicine Overview of Cetaxim 250mg Injection
Introduction
Cetaxim 250 is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the brain, lungs, ear, urinary tract, skin and soft tissues, bones and joints, blood and heart. It is also used to prevent infections during surgery. Cetaxim 250 fights and stops the growth of many types of bacteria. This helps to improve your symptoms and cure the underlying infection. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. Your doctor will decide the correct...
... Show moreUses of Cetaxim 250
- Bacterial infections
Side effects of Cetaxim 250
Common
- Rash
- Allergic reaction
- Nausea
- Injection site reaction
- Diarrhea
How to use Cetaxim 250
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Cetaxim 250 works
Cetaxim 250 is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Cetaxim 250?
If you miss a dose of Cetaxim 250, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Cetaxim 250 to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Discontinue Cetaxim 250 and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Avoid consuming alcohol while taking Cetaxim 250 as it may cause increased side effects.
Brief Description
Indication
Pneumonia, Meningitis, Peritonitis, Pelvic inflammatory disease, Endometritis, Pelvic cellulitis, Gonorrhea, Skin and skin structure infections, Respiratory tract infections, Urinary tract infections, Bacteremia/Septicemia, Bone and/or joint infections
Administration
IV Preparation
Intermittent injection: Reconstitute 1 or 2 g with 10 mL SWI
Infusion: Reconstitute infusion bottles with 50 or 100 mL NS or D5W
IM: Add 2 mL, 3 mL or 5 mL of sterile or bacteriostatic water for inj to a vial
Adult Dose
Adult:
Infections Caused by Susceptible Organisms
Uncomplicated: 1 g IV or IM q12hr
Moderate to severe: 1-2 g IV or IM q8hr
More serious (bloodstream infection [septicemia]): 2 g IV q6-8hr
Life-threatening: 2 g IV q4hr; not to exceed 12 g/day
Surgical prophylaxis 1 g 30-90 mins before procedure.
Gonorrhoea 0.5-1 g as a single dose.
Child Dose
Children: IV, IM 50–180 mg/kg/day q6–8h
200–225 mg/kg/day for meningitis q6h
Neonates:
The recommended dosage is 50 mg/kg/day in 2 to 4 divided doses. In severe infections 150-200 mg/kg/day in divided doses have been given.
Renal Dose
Renal impairment: Severe: After an initial loading dose of 1 g, half the daily dose w/o changing the frequency.
Contraindication
Hypersensitivity to cephalosporins.
Mode of Action
Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
History of penicillin allergy; colitis; impaired renal function; pregnancy, lactation.
Lactation: Drug enters breast milk; use with caution
Side Effect
Colitis, Elevated blood urea nitrogen (BUN) and creatinine, Elevated hepatic transaminases, Fever. Pain at inj site; hypersensitivity reactions, rash, pruritus; diarrhoea, nausea, vomiting; candidiasis; eosinophilia, neutropenia, leucopenia, thrombocytopenia.
Potentially Fatal: Anaphylactic reaction; nephrotoxicity.
Pregnancy Category Note
Pregnancy category: B
Lactation: Drug enters breast milk; use with caution
Interaction
Probenecid decreases cefotaxime elimination.
Potentially Fatal: Nephrotoxicity with furosemide and aminoglycosides.
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