Chlorphen is an antibiotic that fights bacteria. It is used to treat certain types of serious infections caused by bacteria when other antibiotics canno... View More
Uses of Chlorphen
Side effects of Chlorphen
How to use Chlorphen
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Chlorphen is to be taken empty stomach.
How Chlorphen works
Chlorphen is an antibiotic which stops the growth of bacteria. It does so by preventing synthesis of essential proteins required by bacteria to carry ou... View More
Tetracycline-resistant cholera, typhoid, brain abscesses, meningitis, Granuloma inguinale, Anthrax, Listeriosis, Gas gangrene, Whipple's disease, gastro... View More
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Adult: PO Susceptible infections 50 mg/kg/day in 4 divided doses, may increase to 100 mg/kg/day in more severe infections. Hepatic impairment: Dose ... View More
PO Susceptible infections Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divid... View More
Renal impairment: Dose reduction may be required.
History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; pre... View More
Mode of Action
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by pept... View More
Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity. Lactation: enters breast milk;... View More
<1% Nightmares,Headache,Rash,Diarrhea,Stomatitis,Enterocolitis,Nausea,Vomiting,Bone marrow suppression,Aplastic anemia,Peripheral neuropathy,Optic neur... View More
Pregnancy Category Note
Pregnancy Category: C Lactation: enters breast milk; discontinue drug or do not nurse
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of ora... View More