Clinorel 100100mg

Indication

Rheumatoid arthritis, Osteoarthritis, Acute gouty arthritis, Ankylosing spondylitis, Acute painful shoulder

Administration

Should be taken with food.

Adult Dose

Oral Ankylosing spondylitis; Osteoarthritis; Rheumatoid arthritis Adult: For symptomatic treatment: 150 mg bid; may adjust subsequent doses based on r... View More

Child Dose

Safety & efficacy not established

Renal Dose

Renal impairment: May need dosage reduction. Not recommended in severe renal impairment.

Contraindication

Hypersensitivity. Pregnancy (3rd trimester), treatment of peri-operative pain in CABG surgery .

Mode of Action

Sulindac is a prodrug which undergoes reversible reduction to its active sulfide metabolites. It inhibits prostaglandin synthesis by decreasing cyclooxy... View More

Precaution

Use at lowest effective dose for shortest duration possible. NSAIDs may increase risk of severe cardiovascular (CV) thrombotic events, myocardial infarc... View More

Side Effect

1-10% GI pain (10%),Constipation (3-9%),Diarrhea (3-9%),Dizziness (3-9%),Dyspepsia (3-9%),Headache (3-9%),Nausea (3-9%),Rash (3-9%),Abdominal cramps (1... View More

Pregnancy Category Note

Pregnancy Category: C; D in 3rd trimester.

Interaction

Concomittent use with dimethyl sulfoxide may result in peripheral neuropathy. Increased nephrotoxicity with ciclosporin; increased risk of methotrexate ... View More