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Beacon Pharmaceuticals Ltd.
Generic: Agomelatine
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descriptionMedical Overview


PO: 25-50 mg at bedtime. Recommended Dose: 25 mg once daily taken orally at bedtime. Decision of dose increase has to be balanced with a higher risk o... View More


Increased or decreased bioavailabity w/ CYP1A2 (eg, fluvoxamine, ciprofloxacin), oestrogens. CYP1A2 inhibitors (eg propanolol, enoxacin). Decreased bioa... View More

Adult Dose

Suicidal thoughts & worsening of depression. Mania, dementia, lactose intolerance. May affect ability to drive or operate machinery. Pregnancy & lactati... View More

Renal Dose

Agomelatine possesses both melatonin receptor (MT1 and MT2) agonist and 5-hydroxytryptamine receptor (5-HT2C) antagonist properties. These properties ac... View More

Mode of Action

May be taken with or without food.


Major depressive disorder

Side Effect

Renal Impairment: No relevant modification in agomelatine pharmacokinetic parameters in patients with severe renal impairment has been observed.

Pregnancy Category Note

Dizziness, somnolence, insomnia, migraine, headache, nausea, diarrhoea, constipation, upper abdominal pain, hyperhidrosis, back pain, tiredness, anxiety... View More


Co-administration of potent CYP1A2 inhibitors (eg fluvoxamine or ciprofloxacin). Hepatic impairment.


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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