Introduction
Comet 500 is a medicine used to treat type 2 diabetes mellitus. It helps control blood sugar levels and thus prevent serious complications of diabetes. ... View More
Uses of Comet 500
Side effects of Comet 500
How to use Comet 500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Comet 500 is to be taken w... View More
How Comet 500 works
Comet 500 is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) f... View More
What if you forget to take Comet 500?
If you miss a dose of Comet 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your... View More
Indication
Type 2 DM, Polycystic ovarian syndrome,
Administration
Should be taken with food.
Adult Dose
Oral Type 2 diabetes mellitus Adult: Conventional preparation: Initially, 500 mg bid or tid, or 850 mg 1-2 times daily, may increase gradually to 2000... View More
Child Dose
Oral Type 2 diabetes mellitus Child: >10 yr Initially, 500 mg 1-2 times daily or 850 mg once daily, may increase gradually to max 2000 mg daily in 2 o... View More
Renal Dose
Renal impairment Obtain eGFR before starting metformin eGFR <30 mL/min/1.73 m²: Contraindicated eGFR 30-45 mL/min/1.73 m²: Not recommended to initiat... View More
Contraindication
Acute or chronic metabolic acidosis with or without coma (including diabetic ketoacidosis). Renal failure, severe renal or hepatic impairment, acute con... View More
Mode of Action
Metformin is a biguanide w/ antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. It decreases hepatic glucose production by ... View More
Precaution
Caution when used in patients with CHF especially in those with unstable or acute heart failure. Risk of lactic acid accumulation increases with the deg... View More
Side Effect
Anorexia, nausea, vomiting, diarrhoea, wt loss, flatulence, occasional metallic taste; weakness; hypoglycaemia; rash, malabsorption of vit B12. Chest di... View More
Interaction
Additive effect w/ sulfonylureas. Thiazide diuretics, corticosteroids, phenothiazines, OC, sympathomimetics, niacin, Ca channel blockers and isoniazid m... View More
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More