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Comtan 200 mg
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Comtan 200 mg200mg

Tablet
rx_reqRequire Prescription
Novartis (Bangladesh) Ltd.
Generic: Entacapone
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76.69
MRP
82.46
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descriptionSafety Advices
AlcoholAlcohol
UNSAFE
Comtan 200 mg may cause excessive drowsiness with alcohol.
PregnancyPregnancy
CONSULT YOUR DOCTOR
Comtan 200 mg may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the deve... View More
BreastfeedingBreastfeeding
CONSULT YOUR DOCTOR
Comtan 200 mg is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
DrivingDriving
CAUTION
Comtan 200 mg may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
KidneyKidney
SAFE IF PRESCRIBED
Comtan 200 mg is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Comtan 200 mg may not be ... View More
LiverLiver
UNSAFE
Comtan 200 mg is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
descriptionMedical Overview

Introduction

Comtan 200 mg is a prescription medicine used in the treatment of Parkinson's disease. This medicine helps to treat excessive shaking by slowing down th... View More

Uses of Comtan 200 mg

  • Parkinson's disease

Side effects of Comtan 200 mg

Common
  • Nausea
  • Vomiting
  • Fatigue
  • Confusion
  • Constipation
  • Insomnia (difficulty in sleeping)
  • Nightmare
  • Hallucination
  • Increased sweating
  • Fall
  • Urine discoloration
  • Dizziness
  • Diarrhea
  • Muscle coordination impaired
  • Ischemic heart disease
  • Heart attack
  • Abdominal pain
  • Dryness in mouth

How to use Comtan 200 mg

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Comtan 200 mg may be taken... View More

How Comtan 200 mg works

Comtan 200 mg is a selective reversible inhibitor which is given in combination with levodopa. It works by inhibiting a chemical messenger [catechol-O-m... View More

What if you forget to take Comtan 200 mg?

If you miss a dose of Comtan 200 mg, skip it and continue with your normal schedule. Do not double the dose.

quick tipsQuick Tips
  • You have been prescribed Comtan 200 mg to enhance the effectiveness of levodopa for treatment of Parkinson's disease.
  • It can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Inform your doctor if you develop impulsive, unusual behavior and/or an abnormally high sex drive.
  • Talk to your doctor in case you develop hallucinations or other changes in your behavior.
  • It is common to have diarrhea with this drug. Therefore, drink plenty of fluids and watch for weight loss.
  • Do not get worried if you notice a reddish-brown discoloration in your urine as it is harmless in nature.
  • Do not stop taking the medication suddenly without talking to your doctor.
descriptionBrief Description

Indication

Parkinson's disease

Administration

May be taken with or without food.

Adult Dose

Oral Adjunct to levodopa treatment in Parkinson's disease Adult: 200 mg w/ each levodopa/dopa decarboxylase inhibitor dose. Max: 200 mg 10 times daily... View More

Renal Dose

Renal Impairment Dose adjustment not necessary

Contraindication

History of neuroleptic malignant syndrome and nontraumatic rhabdomyolysis. Phaeochromocytoma. Hepatic impairment.

Mode of Action

Entacapone is a selective, reversible, peripheral inhibitor of COMT, an enzyme involved in the metabolism of dopamine and levodopa. It is used in patien... View More

Precaution

Levodopa-induced orthostatic hypotension may be aggravated. Abrupt withdrawal. Concomitant use with a selective MAO-A and MAO-B inhibitor, or concomitan... View More

Side Effect

>10% Dyskinesia (25%),Nausea (14%),Diarrhea (10%),Hyperkinesia (10%),Urine discoloration (10%) 1-10% Hypokinesia (9%),Dizziness (8%),Abdominal pain... View More

Pregnancy Category Note

Pregnancy Category: C Lactation: excretion in milk unknown; use with caution

Interaction

Drugs metabolised by COMT e.g. adrenaline, apomorphine, dobutamine, dopamine, isoprenaline, methyldopa, noradrenaline and remiterol. Iron preparations a... View More

descriptionDisclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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