Introduction
Doxavit 10 is a combination medicine used to treat nausea and vomiting during pregnancy. It prevents the feeling of nausea and sickness in pregnant women. It also provides nutrition to the body.
Doxavit 10 is a prescription medicine. It is advised to take it as per the prescription. It can be taken with or without food, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.
Some common side effects of this medicine are dizziness, stomach pain, constipation, etc. To cope up with the side effects, you should drink plenty of fluid. If any of the side effects get aggravated, contact your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicine for any health condition. Avoid drinking alcohol as it can cause excessive dizziness, also can harm the baby in the womb. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet. To avoid nausea and vomiting during pregnancy, you may drink lemon-infused water. You can also add salad sprinkled with black salt to your diet. Visit your doctor regularly for laboratory and diagnostic tests as per advice.
Uses of Doxavit 10
- Nausea and vomiting in pregnancy
Side effects of Doxavit 10
Common
- Dryness in mouth
- Constipation
- Lightheadedness
- Drowsiness
How to use Doxavit 10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Doxavit 10 may be taken with or without food, but it is better to take it at a fixed time.
How Doxavit 10 works
Doxavit 10 is a combination of two medicines: Doxylamine and vitamin B6 (pyridoxine), which treats nausea and vomiting associated with pregnancy. Doxylamine is an antihistamine which works by blocking the action of a chemical messenger (histamine), thereby controlling nausea, vomiting, and dizziness. Pyridoxine (vitamin B6) is a form of vitamin B which possesses anti-nausea properties.
Indication
Nausea & Vomiting of Pregnancy
Administration
Take on empty stomach with water; food further delays onset of action and lowers peak levels
Swallow tablet whole, do not chew, crush, or split
Adult Dose
Oral
Nausea & Vomiting of Pregnancy
Indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management
Delayed-release Tablet
2 delayed-release tablets PO on a daily basis at bedtime
If symptoms not adequately controlled, increase dose to 4 tablets each day (1 tab in AM, 1 tab mid-afternoon, and 2 tabs at bedtime)
Conventional Tablet
Initially, take one tablet orally at bedtime (Day 1).
If this dose adequately controls symptoms the next day, continue taking one tablet daily at bedtime only.
If symptoms persist, increase the daily dose to one tablet in the morning and one tablet at bedtime.
The maximum recommended dose is two tablets per day, one in the morning and one at bedtime.
Child Dose
<18 years: Safety and efficacy not established
Contraindication
Hypersensitivity
MAO inhibitors intensify and prolong doxylamine’s adverse effects (ie, anticholinergic, CNS)
Mode of Action
Doxylamine: Ethanolamine derivative antihistamine
Pyridoxine: Vitamin B6 analog
Doxylamine is an antihistamine that blocks Histamine (H1) receptor. It affects the vestibular system and decreases the stimulation of the vomiting center. Its mascarinic receptor inhibition may also play a role in antihistamine antiemetic activity.
Pyridoxine (Vitamin B6) is a vitamin used to prevent nausea and vomiting due to its antiemetic properties.
Precaution
Coadministration with alcohol and other CNS depressants may cause additive sedation and is not recommended; combination may cause severe drowsiness leading to falls or accidents
Somnolence due to anticholinergic effects is common; avoid activities requiring mental alertness
Anticholinergic effects may exacerbate conditions such as asthma, increased intraocular pressure, narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, and urinary bladder-neck obstruction
Lactation: Do not breast feed; doxylamine molecular weight is low enough to distribute into human breast milk
Excitement, irritability, and sedation reported in nursing infants presumably exposed to doxylamine through breast milk; infants with apnea or other respiratory syndromes may be particularly vulnerable to the sedative effects resulting in worsening of apnea or respiratory conditions
Pyridoxine is excreted in breast milk; there have been no reports of adverse effects in infants
Side Effect
>10%
Somnolence (14.3%)
Pregnancy Category Note
Pregnancy
Intended for treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management; maternal risks are discussed throughout the labeling; no increased risk for congenital malformations reported in epidemiologic studies in pregnant women
Lactation
Women should not breastfeed while on therapy; molecular weight of doxylamine succinate is low enough that passage into breast milk can be expected; excitement, irritability and sedation reported in nursing infants presumably exposed to doxylamine succinate through breast milk; infants with apnea or other respiratory syndromes may be particularly vulnerable to sedative effects of drug resulting in worsening of their apnea or respiratory conditions
Pyridoxine hydrochloride is excreted into breast milk; adverse events in infants presumably exposed to pyridoxine hydrochloride through breast milk reported