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NPV
Ziska Pharmaceuticals Ltd.
Generic: Doxylamine + Pyridoxine
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with NPV. Please consult your doctor.
SAFE IF PRESCRIBED
NPV is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.
SAFE IF PRESCRIBED
NPV is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Larger doses or prolonged use of NPV may cause sleepiness and other effects in the baby
UNSAFE
NPV may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
NPV is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of NPV may not be needed in these patients. Please consult your doctor.
SAFE IF PRESCRIBED
NPV is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of NPV may not be needed in these patients. Please consult your doctor.
Medicine Overview of NPV 10mg+10mg Tablet
Introduction
NPV is a combination medicine used to treat nausea and vomiting during pregnancy. It prevents the feeling of nausea and sickness in pregnant women. It also provides nutrition to the body. NPV is a prescription medicine. It is advised to take it as per the prescription. It can be taken with or without food, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the...
... Show moreUses of NPV
- Nausea and vomiting in pregnancy
Side effects of NPV
Common
- Dryness in mouth
- Constipation
- Lightheadedness
- Drowsiness
How to use NPV
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. NPV may be taken with or without food, but it is better to take it at a fixed time.
How NPV works
NPV is a combination of two medicines: Doxylamine and vitamin B6 (pyridoxine), which treats nausea and vomiting associated with pregnancy. Doxylamine is an antihistamine which works by blocking the action of a chemical messenger (histamine), thereby controlling nausea, vomiting, and dizziness. Pyridoxine (vitamin B6) is a form of vitamin B which possesses anti-nausea properties.
Quick Tips
- NPV helps treat nausea and vomiting in pregnant women.
- Take it on an empty stomach with a glass of water.
- NPV may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
- Do not take NPV with other sedating medications such as those for cough and cold as the combination could worsen dizziness leading to falls or other accidents.
- Do not take NPV while breastfeeding.
Brief Description
Indication
Nausea & Vomiting of Pregnancy
Administration
Take on empty stomach with water; food further delays onset of action and lowers peak levels
Swallow tablet whole, do not chew, crush, or split
Adult Dose
Oral Nausea & Vomiting of Pregnancy Indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management Delayed-release Tablet 2 delayed-release tablets PO on a daily basis at bedtime If symptoms not adequately controlled, increase dose to 4 tablets each day (1 tab in AM, 1 tab mid-afternoon, and 2 tabs at bedtime) Conventional Tablet Initially, take one tablet orally at bedtime (Day 1). If this dose adequately controls symptoms the next day, continue taking one tablet daily at bedtime only. If symptoms persist, increase the daily dose to one tablet in...
... Show moreChild Dose
<18 years: Safety and efficacy not established
Contraindication
Hypersensitivity
MAO inhibitors intensify and prolong doxylamine’s adverse effects (ie, anticholinergic, CNS)
Mode of Action
Doxylamine: Ethanolamine derivative antihistamine
Pyridoxine: Vitamin B6 analog
Doxylamine is an antihistamine that blocks Histamine (H1) receptor. It affects the vestibular system and decreases the stimulation of the vomiting center. Its mascarinic receptor inhibition may also play a role in antihistamine antiemetic activity.
Pyridoxine (Vitamin B6) is a vitamin used to prevent nausea and vomiting due to its antiemetic properties.
Precaution
Coadministration with alcohol and other CNS depressants may cause additive sedation and is not recommended; combination may cause severe drowsiness leading to falls or accidents Somnolence due to anticholinergic effects is common; avoid activities requiring mental alertness Anticholinergic effects may exacerbate conditions such as asthma, increased intraocular pressure, narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, and urinary bladder-neck obstruction Lactation: Do not breast feed; doxylamine molecular weight is low enough to distribute into human breast milk Excitement, irritability, and sedation reported in nursing infants presumably exposed to doxylamine through breast milk; infants with apnea or other respiratory syndromes may...
... Show moreSide Effect
>10%
Somnolence (14.3%)
Pregnancy Category Note
Pregnancy Intended for treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management; maternal risks are discussed throughout the labeling; no increased risk for congenital malformations reported in epidemiologic studies in pregnant women Lactation Women should not breastfeed while on therapy; molecular weight of doxylamine succinate is low enough that passage into breast milk can be expected; excitement, irritability and sedation reported in nursing infants presumably exposed to doxylamine succinate through breast milk; infants with apnea or other respiratory syndromes may be particularly vulnerable to sedative effects of drug resulting in worsening of their...
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