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Firifam 450450mg

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Sanofi Bangladesh Ltd.
Generic: Rifampicin
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descriptionSafety Advices
It is unsafe to consume alcohol with Firifam 450.
Firifam 450 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the develo... View More
Firifam 450 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is no... View More
Firifam 450 may cause side effects which could affect your ability to drive. You may feel dizzy or faint, have problems with vision or have other side e... View More
Firifam 450 should be used with caution in patients with kidney disease. Dose adjustment of Firifam 450 may be needed. Please consult your doctor.
There is limited information available on the use of Firifam 450 in patients with liver disease. Please consult your doctor.
descriptionMedical Overview


Firifam 450 is an antibiotic, used in the treatment of all forms of tuberculosis, an infectious disease that mainly affects the lungs and in some cases ... View More

Uses of Firifam 450

  • Tuberculosis (TB)

Side effects of Firifam 450

  • Low blood platelets
  • Headache
  • Dizziness
  • Vomiting
  • Abnormal liver function tests
  • Nausea
  • Fever
  • Chills

How to use Firifam 450

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Firifam 450 is to be taken empty stomach.

How Firifam 450 works

Firifam 450 is an antibiotic. It works by inactivating a bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and ... View More

What if you forget to take Firifam 450?

If you miss a dose of Firifam 450, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to yo... View More

quick tipsQuick Tips
  • Your doctor has prescribed Firifam 450 to cure your infection and improve symptoms.
  • It is best taken on an empty stomach. If you get an upset stomach, try taking it with small portions of food.
  • Your urine, tears and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discolored.
  • Tell your doctor about all other medicines you are taking as Firifam 450 can interact with many medicines.
  • Avoid taking hormone-based birth control methods as Firifam 450 may decrease their effectiveness.
  • Tell your doctor immediately if you experience unusual tiredness or loss of appetite, fever or chills.
descriptionBrief Description


Tuberculosis, Leprosy, Brucellosis, Meningitis , Legionnaire's disease; Staphylococcal infections


Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals.

Adult Dose

Oral Tuberculosis Adult: 10 mg/kg/day or 2-3 times/wk. Max: 600 mg/day. <50 kg: 450 mg daily; >50 kg: 600 mg daily. Leprosy 600 mg once mthly.... View More

Child Dose

Oral Tuberculosis 10–20 mg/kg, max 600 mg for TB q24h With directly observed biweekly therapy, dosage is still 10–20 mg/kg/dose (max 600 mg) twice we... View More


Hypersensitivity to rifampicin or other rifamycins. Patient w/ jaundice. Concurrent use w/ saquinavir/ritonavir therapy.

Mode of Action

Rifampicin suppresses initiation of chain formation for RNA synthesis in susceptible bacteria by binding to the beta subunit of DNA-dependent RNA polyme... View More


Patient w/ history of alcoholism. Hepatic and renal impairment. Elderly, malnourished patients, childn <2 yr. Pregnancy and lactation. Patient Counselli... View More

Side Effect

Facial flushing and itching, w/ or w/o a rash, flu-like syndrome characterised by episodes of fever, chills, headache, dizziness, bone pain, shortness o... View More


May accelerate the metabolism and reduce the effect of drugs that are metabolised by CYP450 enzymes (e.g. quinidine, phenytoin, theophylline). Decreased... View More

Alternative brand for Firifam 450
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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