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Safety Advices
বাংলা
English
UNSAFE
Gpentin may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Gpentin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Gpentin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Baby should be monitored for excessive sleepiness and weight gain.
UNSAFE
Gpentin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Gpentin should be used with caution in patients with kidney disease. Dose adjustment of Gpentin may be needed. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Gpentin in patients with liver disease. Please consult your doctor.
Medicine Overview of Gpentin 5gm/100ml Syrup
Introduction
Gpentin is a medicine used to relieve the pain caused by nerve damage (neuropathic pain) due to various conditions like diabetes, shingles (herpes zoster infection), spinal cord injury, etc. It is also used to treat certain types of seizures (fits) in combination with other medicines. Gpentin belongs to the anti-epileptic group of medicines. You may take it with or without food, but it is important to take this medicine at the same time each day to get the most benefit. The exact dose and duration of treatment will depend on your condition and how you respond to it. Your doctor...
... Show moreUses of Gpentin
- Neuropathic pain
- Epilepsy/Seizures
Side effects of Gpentin
Common
- Dizziness
- Fatigue
- Fever
- Impaired coordination
- Nausea
- Nystagmus (involuntary eye movement)
- Peripheral edema
- Sleepiness
- Viral infection
- Vomiting
How to use Gpentin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Gpentin may be taken with or without food, but it is better to take it at a fixed time.
How Gpentin works
Gpentin is an antiepileptic medication. When given for epilepsy, it is believed to work by reducing the abnormal electrical activity in the brain, thus preventing seizures. It is also used to treat nerve pain where it blocks pain by interfering with pain signals travelling through the damaged nerves and the brain.
What if you forget to take Gpentin?
If you miss a dose of Gpentin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take it at the same time every day, preferably at bedtime, to avoid any dizziness or drowsiness during the day.
- Avoid taking antacids 2 hours before or after taking Gpentin as they make it harder for your body to absorb the medicine.
- It may cause sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
- Do not stop taking Gpentin suddenly without talking to your doctor as it may increase the frequency of seizure.
Brief Description
Indication
Epilepsy, Neuropathic pain, Partial Seizures, Hot flashes, Fibromyalgia, Postherpetic Neuralgia, Pain from diabetic neuropathy.
Administration
May be taken with or without food.
Adult Dose
Partial Seizures Adjunctive therapy for partial seizures with or without secondary generalization Initial: 300 mg PO q8hr May increase up to 600 mg PO q8hr; up to 2400 mg/day administered and tolerated in clinical studies; up to 3600 mg administered for short duration and tolerated Postherpetic Neuralgia Day 1: 300 mg PO qDay Day 2: 300 mg PO q12hr Day 3: 300 mg PO q8hr Maintenance: Subsequently titrate as needed up to 600 mg PO q8hr; doses >1800 mg/day have demonstrated no additional benefit Restless legs syndrome 100-300 mg PO 2 hr before bedtime on first day; may titrate every...
... Show moreChild Dose
Partial Seizures
Adjunctive therapy for partial seizures with or without secondary generalization in patients older than 12 years of age with epilepsy; also indicated as adjunctive therapy for partial seizures in pediatric patients aged 3-12 years
12 years (initial dose): 300 mg PO q8hr; may increase up to 600 mg PO q8hr
Renal Dose
Renal impairment
CrCl >60 mL/min: 300-1200 mg PO TID
CrCl 30-60 mL/min: 200-700 mg q12hr
CrCl 15-29 mL/min: 200-700 mg qDay
CrCl <15 mL/min: 100-300 mg qDay
Hemodialysis (CrCl <15 mL/min): Administer supplemental dose (range 125-350 mg) posthemodialysis, after each 4 hr dialysis interval; further dose reduction should be in proportion to CrCl (eg, CrCl of 7.5 mL/min should receive one-half daily posthemodialysis dose)
Contraindication
Hypersensitivity. Lactation.
Mode of Action
Gabapentin is structurally related to the neurotransmitter GABA but is neither a GABA agonist nor antagonist. High affinity gabapentin binding sites are located throughout the brain. These sites correspond to the presence of voltage-gated Ca channels particularly controlling the ?-2/?-1 subunit. This channel appears to be located presynaptically and may modulate the release of excitatory neurotransmitters which participate in epileptogenesis and nociception.
Precaution
Discontinuation or transfer from other antiepileptics, history of psychotic illness; renal impairment; pregnancy. Gradual withdrawal over at least 7 days to prevent an increase in seizure frequency.
Lactation: Enters breast milk; use with caution
Side Effect
>10%
Ataxia (1-13%),Dizziness (16-20%),Drowsiness (5-21%),Fatigue (11-15%),Somnolence (16-20%)
1-10%
Diplopia (6-10%),Nystagmus (6-10%),Tremor (6-10%),Amblyopia (1-5%),Back pain (1-5%),Constipation (1-5%),Depression (1-5%),Dry mouth (1-5%),Dysarthria (1-5%),Dyspepsia (1-5%),Hostility (5-8% children),Hyperkinesia (3-5%),Increased appetite (1-5%),Leukopenia (1-5%),Myalgia (1-5%),Nervousness (1-5%),Peripheral edema (1-5%),Pharyngitis (1-5%),Pruritus (1-5%),Rhinitis (1-5%),Vasodilation (1-5%),Weight gain (1-5%),Abnormal vision (>1%),Anorexia (>1%),Arthralgia (>1%),Asthenia (>1%),HTN (>1%),Malaise (>1%),Paresthesia (>1%),Purpura (>1%),Vertigo (>1%)
Interaction
May increase plasma level w/ morphine. Reduced absorption w/ antacids.
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