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Medicine Overview of Havrix 1440 (Adult0 1440EU/ml Injection
বাংলা
English
Indication
Active immunisation against Hepatitis A virus
Adult Dose
Intramuscular
Active immunisation against hepatitis A
Adult: 2-dose vaccination series: 1 mL IM; separate the 2 doses by 6-12 months
Child Dose
Intramuscular
Active immunisation against hepatitis A
Child: Indicated as routine vaccination for children at least 12 months of age (ACIP guidelines)
2 yr who has not already received hepatitis A vaccine series, give 2 doses separated by 6-18 months if immunity against hepatitis A virus infection is desired
Minimum interval between the 2-dose series is 6 months
Contraindication
Hypersensitivity. Vaccines prepared in egg cultures are contraindicated in patients with hypersensitivity reactions to egg. Severe immunodeficiency. Malignant disease being treated with chemotherapy or radiotherapy and for at least 6 mth after stopping treatment. Patients with compromised immune system such as those on high-dose systemic corticosteroids, immunosuppressants or HIV positive.
Mode of Action
Hepatitis A antigen is prepared from formaldehyde-inactivated hepatitis A virus grown in human diploid cells. It is used for active immunisation against hepatitis A infection.
Precaution
Alcohol or disinfectant used for cleaning the skin prior to inj should be allowed to evaporate completely before vaccination to prevent vaccine inactivation.
Lactation: not established
Side Effect
>10%
Injection site tenderness (3-56%), erythema (1-22%), warmth (1-17%), swelling (9-11%),Irritability (11-36%),Anorexia (1-19%),Drowsiness (15-17%),Headache (1-16%),Fever > 100.4 F (9-11%)
1-10%
URI (1-10%),Otitis media (8%),Rhinorrhea (6%),Diarrhea (1-6%),Cough (1-5%),Rash (1-5%),Weakness/fatigue (4%),Vomiting (1-4%),Fever > 102 F (3%),Crying (2%)
<1%
Hematoma,Incr. CPK,Photophobia,Vertigo
Potentially Fatal: Anaphylaxis.
Interaction
Reduced response to vaccination when used concurrently with immunosuppressants such as corticosteroids or antineoplastics.