Kanaquine300mg

Indication

Malaria, Nocturnal leg cramps

Administration

Should be taken with food. Take w/ food to minimise GI discomfort.

Adult Dose

Oral Malaria Adult: As sulfate: 648 mg 8 hrly for 7 days. Nocturnal leg cramps Adult: 200-300 mg once at night. Hepatic impairment: Mild to mo... View More

Child Dose

Oral Malaria Child: As sulfate: >8 yr10 mg/kg 8 hrly for 7 days.

Renal Dose

Renal impairment: Severe: Initially, 648 mg followed after 12 hr by maintenance doses of 324 mg 12 hrly.

Contraindication

Hypersensitivity to quinine, mefloquine or quinidine. Patients w/ nocturnal leg cramps; prolonged QT interval, tinnitus or optic neuritis, myasthenia gr... View More

Mode of Action

Quinine is a cinchona alkaloid and a 4-methanolquinoline. It rapidly acts on blood schizontocide by interfering w/ lysosomal function or nucleic acid sy... View More

Precaution

Patients w/ cardiac conduction defects, heart block or AF. Pregnancy and lactation. Monitoring Parameters Monitor for signs of cardiotoxicity. Monitor b... View More

Side Effect

<1% Flushing of the skin,Anginal symptoms,Fever,Rash,Pruritus,Hypoglycemia,Epigastric pain,Hemolysis in G6PD deficiency,Thrombocytopenia,Hepatitis,Nigh... View More

Interaction

Reduced renal clearance of amantadine. Reduced clearance w/ cimetidine. Increased anticoagulant effect of warfarin and other anticoagulants. Reduced pla... View More