Globe Pharmaceuticals Ltd.
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Malaria, Nocturnal leg cramps
Should be taken with food. Take w/ food to minimise GI discomfort.
Oral Malaria Adult: As sulfate: 648 mg 8 hrly for 7 days. Nocturnal leg cramps Adult: 200-300 mg once at night. Hepatic impairment: Mild to mo... View More
Oral Malaria Child: As sulfate: >8 yr10 mg/kg 8 hrly for 7 days.
Renal impairment: Severe: Initially, 648 mg followed after 12 hr by maintenance doses of 324 mg 12 hrly.
Hypersensitivity to quinine, mefloquine or quinidine. Patients w/ nocturnal leg cramps; prolonged QT interval, tinnitus or optic neuritis, myasthenia gr... View More
Mode of Action
Quinine is a cinchona alkaloid and a 4-methanolquinoline. It rapidly acts on blood schizontocide by interfering w/ lysosomal function or nucleic acid sy... View More
Patients w/ cardiac conduction defects, heart block or AF. Pregnancy and lactation. Monitoring Parameters Monitor for signs of cardiotoxicity. Monitor b... View More
<1% Flushing of the skin,Anginal symptoms,Fever,Rash,Pruritus,Hypoglycemia,Epigastric pain,Hemolysis in G6PD deficiency,Thrombocytopenia,Hepatitis,Nigh... View More
Reduced renal clearance of amantadine. Reduced clearance w/ cimetidine. Increased anticoagulant effect of warfarin and other anticoagulants. Reduced pla... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More