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Safety Advices
বাংলা
English
UNSAFE
Lamotrigine may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Lamotrigine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Lamotrigine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Monitor the baby for rash, sleepiness or poor sucking. Also, get the platelet count and liver function test done periodically.
UNSAFE
Lamotrigine may cause side effects which could affect your ability to drive.
Lamotrigine can cause dizziness and double vision. This may affect your ability to drive.
CAUTION
Lamotrigine should be used with caution in patients with kidney disease. Dose adjustment of Lamotrigine may be needed. Please consult your doctor.
CAUTION
Lamotrigine should be used with caution in patients with liver disease. Dose adjustment of Lamotrigine may be needed. Please consult your doctor.
Medicine Overview of Lamotrigine 100mg Tablet
Introduction
Lamotrigine belongs to a group of medicines called anti-epileptics. It is used to treat two conditions, epilepsy and bipolar disorder. It works by blocking the signals in the brain that trigger epileptic seizures (fits) and in another way to prevent extreme mood swings. Lamotrigine can be used alone or in combination with other medicines. It may be taken with or without food. Your doctor will decide the correct dose for you. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the maximum...
... Show moreUses of Lamotrigine
- Epilepsy/Seizures
- Bipolar disoder
Side effects of Lamotrigine
Common
- Skin rash
- Headache
- Nausea
- Vomiting
- Dryness in mouth
- Insomnia (difficulty in sleeping)
- Sleepiness
- Dizziness
- Back pain
- Abdominal pain
- Blurred vision
- Double vision
- Impaired coordination
- Nasal congestion (stuffy nose)
- Infection
How to use Lamotrigine
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lamotrigine may be taken with or without food, but it is better to take it at a fixed time.
How Lamotrigine works
Lamotrigine is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
What if you forget to take Lamotrigine?
If you miss a dose of Lamotrigine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- It may cause headaches. Drink plenty of water and take a suitable pain killer. Inform your doctor if it does not go away.
- It may cause skin rash. Inform your doctor immediately if you notice a rash, itching and peeling of skin.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Do not stop taking the medication suddenly without talking to your doctor as it may increase the frequency of seizure.
Brief Description
Indication
Epilepsy,—adjunctive therapy in patients aged 2 years and older:
• partial-onset seizures.
• primary generalized tonic-clonic seizures.
• generalized seizures of Lennox-Gastaut syndrome
Epilepsy,—monotherapy in patients aged 16 years and older
Bipolar disorder
Administration
May be taken with or without food.
Adult Dose
Oral Epilepsy Adult: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100-200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily. Adjunct in epilepsy Adult: With valproate: Initially, 25 mg on alternate days for 2 wk followed by 25 mg once daily for 2 wk; thereafter, increase by a max of 25-50 mg every 1-2 wk; usual maintenance doses: 100-200 mg daily...
... Show moreChild Dose
Oral Epilepsy Child: >12 yr: Initially, 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk; thereafter, increase the dose by a max of 50-100 mg every 1-2 wk to usual maintenance doses of 100 -200 mg daily, as a single dose or in 2 divided doses. Some patients may require up to 500 mg daily. <12 yr: Not recommended. Adjunct in epilepsy Child: With valproate: Initially, 0.15 mg/kg once daily for 2 wk followed by 0.3 mg/kg once daily for 2 wk; thereafter, increase by a max of 0.3 mg/kg every 1-2 wk...
... Show moreRenal Dose
Renal impairment
Use caution; may consider reduce the dose in significant renal impairment
Contraindication
Hypersensitivity.
Mode of Action
Lamotrigine inhibits voltage-sensitive sodium channels, thereby stabilising neuronal membranes and consequently inhibiting pathological release of excitatory amino acids (e.g. glutamate and aspartate). These amino acids play a role in the generation and spread of epileptic seizures.
Precaution
Hepatic or renal impairment. Closely monitor patient. Monitor children's body wt. Advise patient to report any hypersensitivity reaction. Avoid abrupt withdrawal unless severe skin reactions have developed. May impair ability to drive or operate machinery. Pregnancy and lactation. Serious skin rashes, Blood Dyscrasias, Suicidal Behavior, Aseptic Meningitis can occur in both adult and pediatric population.
Lactation: Distributed into human breast milk; caution advised
Side Effect
>10%
Dizziness (38%),Diplopia (26-30%),Headache (29%),Ataxia (22%),Blurred vision (16-20%),Rhinitis (11-15%),Somnolence (14%)
1-10%
Insomnia (6-10%),Fatigue (8%),Chest pain (5%),Peripheral edema (2-5%),Suicidal ideation (2-5%),Dermatitis (2-5%),Dry skin (2-5%),Increased libido (2-5%),Rectal hemorrhage (2-5%),Weakness (2-5%),Agitation (1-5%),Dysarthria (1-5%),Edema (1-5%),Fever (1-5%),Migraine (1-5%),Abnormal thoughts (1-5%),Urinary frequency (1-5%),Tremor (4%)
Frequency Not Defined
Palpitations,Anxiety,Chills,Depression,Decreased memory,Emotional lability,Incoordination,Malaise,Seizure exacerbation,Vertigo,Pruritus,Rash,Amenorrhea,Hot flashes,Abdominal pain,Constipation,Diarrhea,Dyspepsia,Nausea,Vomiting,Arthralgia,Neck pain,Cough,Flu syndrome,Infection,Vaginitis,Nystagmus
Potentially Fatal: Stevens-Johnson syndrome and toxic epidermal necrolysis.
Interaction
Metabolism enhanced by enzyme-inducing drugs e.g. phenytoin, carbamazepine, phenobarbitone, primidone, rifampicin, ethinyloestradiol/levonorgestrel combination. Metabolism reduced by sodium valproate.
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