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Larcan
Opsonin Pharma Limited
Generic: Lercanidipine Hydrochloride
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Larcan. Please consult your doctor.
CONSULT YOUR DOCTOR
Larcan may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Larcan is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
CAUTION
Larcan may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
CAUTION
Larcan should be used with caution in patients with kidney disease. Dose adjustment of Larcan may be needed. Please consult your doctor.
Use of Larcan is not recommended in patients with severe kidney disease.
CAUTION
Larcan should be used with caution in patients with liver disease. Dose adjustment of Larcan may be needed. Please consult your doctor.
Use of Larcan is not recommended in patients with severe liver disease.
Medicine Overview of Larcan 10mg Tablet
Introduction
Larcan is a medicine used to treat high blood pressure (hypertension). It belongs to a group of medicines known as calcium channel blockers and helps to lower blood pressure and reduce the workload of the heart. This helps prevent heart attacks and strokes. Larcan may be prescribed alone or along with other medicines. The dose depends on your blood pressure levels and the severity of your condition. You can take it at any time of the day, but it is best to take it at the same time each day. It should be taken on an empty stomach, at least...
... Show moreUses of Larcan
- Hypertension (high blood pressure)
Side effects of Larcan
Common
- Dizziness
- Edema (swelling)
- Fatigue
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Headache
- Palpitations
How to use Larcan
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Larcan is to be taken empty stomach.
How Larcan works
Larcan is a calcium channel blocker. It regulates the blood pressure by relaxing the blood vessels and reducing the pressure on them, thereby making it easier for the heart to pump more blood throughout the body. In this way, it treats to normalize the blood pressure in patients with high blood pressure.
What if you forget to take Larcan?
If you miss a dose of Larcan, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take it at the same time every day to help you remember to take it.
- A sudden drop in your blood pressure may occur, especially when you first start taking Larcan. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- It can cause ankle or foot swelling. To reduce the swelling, raise your legs while you are sitting down. Talk to your doctor if it does not go away.
- It may cause dizziness. Do not drive or perform any activity that requires mental focus until you know how Larcan affects you.
- Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding.
Brief Description
Indication
Mild to moderate essential hypertension, Stroke prevention.
Administration
Should be taken on an empty stomach. Take on an empty stomach at least 15 min before meals.
Adult Dose
Oral
Hypertension
Adult: As hydrochloride: 10 mg once daily, increased after 2 wk to 20 mg daily if necessary.
Elderly: The recommended dosage is 10 mg orally once a day at least 15 minutes before meals; the dose may be increased to 20 mg depending on the individual patient's response.
Hepatic impairment: Special care should be exercised in patients with mild to moderate renal or hepatic dysfunction.
Dosage above 20 mg daily must be approached with caution. Lercanidipine is not recommended for use in patients with severe hepatic dysfunction.
Renal Dose
Renal impairment: Dosage may need to be reduced in mild to moderate renal impairment. Avoid in patients with CrCl <12 ml/min.
Contraindication
Severe hepatic or renal impairment; aortic stenosis, unstable angina, uncontrolled heart failure, within 1 mth of MI; and known hypersensitivity to any dihydropyridine. Lercanidipine should not be taken with grapefruit juice. lactation, pregnancy.
Mode of Action
Lercanidipine is a dihydropyridine calcium-channel blocker which acts by inhibiting the influx of calcium ions through the slow channels of the vascular smooth muscle and myocardium during depolarization. Its main effect is vasodilatation because it has greater selectivity for vascular smooth muscle than cardiac smooth muscle.
Precaution
Left ventricular dysfunction, sick sinus syndrome (if pacemaker not fitted), left ventricular dysfunction and ischaemic heart disease.
Side Effect
Tachycardia, oedema, flushing, headache, dizziness, asthenia, rash, diarrhoea, polyuria, palpitations, hypotension, drowsiness, myalgia.
Interaction
Plasma concentration reduced by inducers of CYP3A4 eg rifampicin, phenytoin, carbamazepine. Bioavailability also reduced by metoprolol and possibly propranolol. Plasma concentrations increased by inhibitors of CYP3A4 eg imidazole antifungals, erythromycin, ritonavir, fluoxetine. Alcohol may potentiate vasodilating effect.
Potentially Fatal: Significantly increased plasma levels of both lercanidipine and ciclosporin when administered together.
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