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Larimef
Healthcare Pharmaceuticals Ltd.
Generic: Mefloquine
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Larimef. Please consult your doctor.
CONSULT YOUR DOCTOR
Larimef may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Larimef is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Larimef may cause side effects which could affect your ability to drive.
Larimef can cause dizziness, loss of balance and mental problems and this may affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Larimef in patients with kidney disease. Please consult your doctor.
CAUTION
Larimef should be used with caution in patients with liver disease. Dose adjustment of Larimef may be needed. Please consult your doctor.
Use of Larimef is not recommended in patients with severe liver disease.
Medicine Overview of Larimef 250mg Tablet
Introduction
Larimef is an antiparasitic medicine, used for the treatment of malaria. It works by killing the malaria causing parasite and stops the infection from spreading. Larimef should be used in the dose and duration as advised by your doctor. Take it with food to decrease the risk of stomach upset. Do not skip any doses and finish the full course of treatment even if you feel better. Some people may have stomach pain, abnormal dreams, chills, depression, and diarrhea, as side effects of this medicine. Please consult your doctor if these side effects persist for a longer duration. Inform your...
... Show moreUses of Larimef
- Malaria
Side effects of Larimef
Common
- Abdominal pain
- Abnormal dreams
- Anxiety
- Chills
- Depression
- Diarrhea
- Dizziness
- Fever
- Headache
- Atrial arrhythmias (altered heart rate)
- Insomnia (difficulty in sleeping)
- Itching
- Loss of appetite
- Muscle pain
- Nausea
- Rash
- Ringing in ear
- Vertigo
- Visual impairment
- Vomiting
- Fatigue
How to use Larimef
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Larimef is to be taken with food.
How Larimef works
Larimef is an antiparasitic medication which treats malaria. It works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading.
Quick Tips
- Larimef should be taken with food to prevent a stomach upset.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Tips to reduce the chance of being bitten by mosquitoes:
- It may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
- Inform your doctor if you have kidney liver or heart disease.
Brief Description
Indication
Malaria
Administration
Should be taken with food. Best taken w/ meals & a full glass of water.
Should be taken on the same day of each week.
Adult Dose
Oral
Acute Malaria
Adult: 5 tablets (Total 1250 mg) as a single oral dose. OR
750 mg orally as initial dose, followed by 500 mg orally 6 to 12 hours after initial dose. Total dose 1,250 mg.
Malaria prophylaxis
250 mg once weekly, taken 1-3 wk before exposure and continuing for 4 wk after leaving the endemic area.
Dosing Considerations
If a full-treatment course does not lead to improvement within 48-72 hr, mefloquine should not be used for retreatment; an alternative therapy should be used
Similarly, if previous prophylaxis with mefloquine failed, mefloquine should not be used for curative treatment
Child Dose
Oral
Acute Malaria
6 months: 20-25 mg/kg PO as single dose. Maximum total dose: 1250 mg. OR
15 mg/kg as initial dose, followed by 10 mg/kg po given 6-12 hours after initial dose. Total dose= 25 mg/kg
Malaria prophylaxis
Child:
5 to 45 kg: 250 mg (1 tablet) PO qWeek
Start 1-2 weeks before arrival in endemic area; continue 4 weeks after leaving endemic area
Contraindication
Hypersensitivity to related compounds (e.g. quinine and quinidine); history of blackwater fever;, prophylactic use in patients w/ history of psychiatric (including depression) or convulsive disorders; retreatment w/ mefloquine. Severe hepatic impairment. Concomitant use w/ halofantrine.
Mode of Action
Mefloquine is a 4-methanolquinine antimalarial agent and a blood schizontocide which acts by interfering w/ the parasite's ability to metabolise and utilise erythrocyte Hb. It is active against most Plasmodium sp and is used for prophylaxis and treatment against malaria.
Precaution
Epilepsy; delay admin until at least 12 hr after the last dose of quinine/quinine-related compounds (monitoring of cardiac and neurological functions is warranted). Avoid driving or operating machines during and up to 3 wk after mefloquine use. Pregnancy, lactation; cardiac conduction disturbances; children <3 mth or 5 kg.
Lactation: Minimally excreted in human breast milk; based on a study in a few subjects, low concentrations (3% to 4%) excreted; caution advised
Side Effect
1-10%
Anxiety,Difficulty concentrating,Headache,Insomnia,Lightheadedness,Vertigo,Vomiting,Diarrhea,Stomach pain,Nausea,Visual disturbances,Tinnitus
Frequency Not Defined
Suicidal depression,Psychiatric Sx,Pneumonitis,Seizure,Abnormal ECG
Potentially Fatal: Seizures, thrombocytopenia, leucopenia, AV block, encephalopathy.
Interaction
Increased risk of ECG abnormalities w/ quinine or chloroquine, antihistamines, TCAs and phenothiazines. May increase risk of seizure w/ quinidine or quinine. Concomitant use w/ valproic acid, phenobarbital, carbamazepine and phenytoin may cause loss of seizure control and lower plasma levels of anticonvulsants. Increased risk of QT prolongation and arrhythmia w/ ketoconazole. Concomitant use w/ digoxin, Ca-channel blockers, antiarrhythmics and ?-blockers may increase the risk of cardiotoxicity. Increased risk of ventricular arrhythmias w/ amiodarone. Concomitant use w/ TCAs, SSRIs, buprion, antipsychotic, tramadol may increase the risk of convulsions. Increased plasma levels w/ metoclopromide. May compromise adequate immunisation by live typhoid...
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