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Safety Advices
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CAUTION
Caution is advised when consuming alcohol with Lescol. Please consult your doctor.
UNSAFE
Lescol is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
Lescol is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Lescol does not usually affect your ability to drive.
CAUTION
Lescol should be used with caution in patients with severe kidney disease. Dose adjustment of Lescol may be needed. Please consult your doctor.
Limited information is available on the use of Lescol in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
CAUTION
Lescol should be used with caution in patients with liver disease. Dose adjustment of Lescol may be needed. Please consult your doctor.
Use of Fluvastatin is not recommended in patients with active liver disease and severe liver disease.
Medicine Overview of Lescol 40mg Capsule
Introduction
Lescol belongs to a group of medicines called statins. It is used to lower cholesterol and to reduce the risk of heart disease. Cholesterol is a fatty substance that builds up in your blood vessels and causes narrowing, which may lead to a heart attack or stroke. Lescol is regarded as safe for long-term use when taken as per the doctor's advice. It can be taken with a meal or on an empty stomach. You can take it at any time of the day but try to take it at the same time each day. Most people with high cholesterol...
... Show moreUses of Lescol
- High cholesterol
- Prevention of heart attack and stroke
Side effects of Lescol
Common
- Abdominal pain
- Headache
- Muscle pain
- Weakness
How to use Lescol
Use it as advised by your doctor or check the label for directions before use. Lescol may be taken with or without food, but it is better to take it at a fixed time.
How Lescol works
Lescol is a lipid-lowering medication (statin). It works by blocking an enzyme (HMG-CoA-reductase) that is required in the body to make cholesterol. It thus lowers "bad" cholesterol (LDL) and triglycerides, raising the level of "good" cholesterol (HDL).
What if you forget to take Lescol?
If you miss a dose of Lescol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Inform your doctor if you experience fatigue, muscle weakness or muscle pain.
- Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver problems such as stomach pains, unusually dark urine or yellowing of skin or eyes.
- Inform your doctor if you have kidney disease, liver disease or diabetes before starting treatment with this medicine. If you are diabetic, monitor your blood sugar level regularly as Lescol XL 80mg Tablet may cause an increase in your blood sugar level.
- Do not take Lescol XL 80mg Tablet if you are pregnant, planning a pregnancy or breastfeeding.
Brief Description
Indication
Hyperlipidaemias, Hypercholesterolemia
Administration
May be taken with or without food.
Adult Dose
Oral
Hypercholesterolemia & Mixed Dyslipidemia
Adult: Initially, 20-40 mg once daily in the evening, may increase at intervals of 4 wk to max 80 mg/day in 12hrly divided dose.
Hepatic Impairment
Contraindicated in active liver disease or unexplained transaminase elevations
Child Dose
Oral
Hyperlipidaemias
Child: Heterozygous familial hypercholesterolaemia: 10-16 yr 20 mg once daily. If necessary, may increase dose at 6-wkly intervals to 40 mg bid or 80 mg once daily as modified-release.
Renal Dose
Renal Impairment
CrCl <30 mL/min: Adjust dose amount; not to exceed 40 mg/day
Contraindication
Acute liver disease; unexplained persistently raised serum aminotransferase concentrations; porphyria; pregnancy; lactation.
Mode of Action
Fluvastatin acts by competitively inhibiting HMG-CoA reductase, the enzyme for cholesterol synthesis. It reduces total cholesterol, triglycerides, LDL and VLDL concentrations in plasma. It also increases HDL concentrations.
Precaution
History of liver disease; high alcohol intake. Manage hypothyroidism adequately before starting treatment. Report unexplained muscle pain. Monitor LFTs. Discontinue in case of marked or persistent increase in serum aminotransferase or creatine phosphokinase. Severe renal impairment.
Lactation: enters breast milk; contraindicated
Side Effect
1-10%
Headache (9%),Dyspepsia (8%),Abdominal pain (5%),Diarrhea (5%),Myalgia (5%),Fatigue (3%),Insomnia (3%),Nausea (3%),Sinusitis (3%),Bronchitis (2%),UTI (2%),Transaminases increased (1.1%)
<1%
Rash,Back pain,Arthralgia,Myopathy,Rhabdomyolysis,Rupture of tendon,CPK increased,Pharyngitis,Rhinitis,Cough,Constipation,Pancreatitis,Dizziness
Pregnancy Category Note
Pregnancy Category: X
Lactation: enters breast milk; contraindicated
Interaction
Bleeding and increased prothrombin time w/ coumarin anticoagulants. May increase the risk of myopathy and rhabdomyolysis w/ HIV protease inhibitors, colchicine, bezafibrate, ciprofibrate or niacin (nicotinic acid), ciclosporin and fluconazole. Reduced bioavailability w/ concomitant rifampicin.