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Lesero 500
Ziska Pharmaceuticals Ltd.
Generic: Ceftazidime
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Lesero 500 does not cause any harmful side effects.
SAFE IF PRESCRIBED
Lesero 500 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Lesero 500 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoid prolonged use of Lesero 500, since it may have possible effects such as rash and diarrhea.
UNSAFE
Lesero 500 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Lesero 500 should be used with caution in patients with kidney disease. Dose adjustment of Lesero 500 may be needed. Please consult your doctor.
CAUTION
Lesero 500 should be used with caution in patients with severe liver disease. Dose adjustment of Lesero 500 may be needed. Please consult your doctor.
Medicine Overview of Lesero 500mg/vial Injection
Introduction
Lesero 500 is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the brain, lungs, ear, urinary tract, skin and soft tissues, bones and joints, blood and heart. It is also used to prevent infections during surgery. Lesero 500 fights and stops the growth of many types of bacteria. This helps to improve your symptoms and cure the underlying infection. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. Your doctor will decide the correct...
... Show moreUses of Lesero 500
- Bacterial infections
Side effects of Lesero 500
Common
- Rash
- Allergic reaction
- Injection site reaction
- Diarrhea
How to use Lesero 500
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Lesero 500 works
Lesero 500 is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Lesero 500?
If you miss a dose of Lesero 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Lesero 500 to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Discontinue Lesero 500 and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Avoid consuming alcohol while taking Lesero 500 as it may cause increased side effects.
Brief Description
Indication
Pneumonia, Cystic fibrosis, Bacterial septicemia, Meningitis, Peritonitis, Skin and Skin-Structure Infections, Endometritis, Pelvic cellulitis, Respiratory tract infections, Urinary tract infections, Febrile neutropenia, Melioidosis, Bone and Joint Infections,G ynecologic Infections, Biliary tract infections, Endophthalmitis
Administration
IV/IM Administration
IV
Direct injection: Inject over 3-5 minutes directly into vein or through tubing of running compatible infusion solution
Infusion: Infuse intermittently over 15-30 minutes
IM
Inject deeply
Adult Dose
Bone & Joint Infections
2 g IV q12hr
Gynecologic & Intra-abdominal Infections, Meningitis, Complicated Pneumonia, Life-Threatening Infections
2 g IV q8hr
Pulmonary Infections
Infections caused by Pseudomonas spp in patients with cystic fibrosis who have healthy renal function
30-50 mg/kg IV q8hr; not to exceed 6 g/day
Uncomplicated Pneumonia
0.5-1 g IV q8hr
Mild Skin/Skin Structure Infections
0.5-1 g IV or IM q8hr
Urinary Tract Infections
Complicated: 500 mg IV or IM q8-12hr
Uncomplicated: 250 mg IV or IM q12hr
Elderly: >80 yr Max: 3 g daily.
Child Dose
Child: IV, IM 90–150 mg/kg/day q8h
IV 200–300 mg/kg/day for serious Pseudomonas infection (max 8–12 g/day) q8h
Renal Dose
Renal impairment: Loading dose: 1 g; maintenance doses based on CrCl. May need to increase doses by 50% in severe infections. Peritoneal dialysis: Loading dose is followed by 500 mg every 24 hr; may add ceftazidime to the dialysis fluid (usually 125-250 mg for 2 litres of dialysis fluid). Haemodialysis: Admin loading dose then 0.5-1 g after each dialysis period.
CrCl (ml/min)
31-50 1 g every 12 hr.
16-30 1 g every 24 hr.
6-15 500 mg every 24 hr.
<5 500 mg every 48 hr.
Contraindication
Hypersensitivity to cephalosporins.
Mode of Action
Ceftazidime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
History of penicillin allergy; severe renal impairment; pregnancy, lactation.
Lactation: Drug excreted in breast milk; use with caution
Side Effect
1-10%
Transient increases in transaminases (3-9%),Eosinophilia (<7%),Diarrhea (<2%),Immune hypersensitivity reaction (2%),Phlebitis (<2%),Rash (maculopapular or erythematous) (2%),Thrombocytosis (2%),Injection site pain (1%)
<1%
Abdominal pain,Agranulocytosis,Angioedema,Asterixis,Coma,Dizziness,Encephalopathy,Fever,Hallucinations,Increased serum concentrations of bilirubin,Leukopenia,Lymphocytosis,Metallic taste,Myoclonia,Nausea or vomiting,Neuromuscular excitability,Neutropenia,Paresthesia,Photosensitivity,Pruritus,Seizures,Thrombocytopenia,Transient increases in blood urea nitrogen (BUN) or serum creatinine,Urticaria
Potentially Fatal: Anaphylactic reactions, nephrotoxicity, pseudomembranous colitis.
Pregnancy Category Note
Pregnancy category: B
Lactation: Drug excreted in breast milk; use with caution
Interaction
May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid.
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