The daily dose of Vescap is 4 grams per day taken as Two 1 gm capsules twice daily with food. Advise patients to swallow capsules whole. Do not break open, crush, dissolve, or chew Vescap.Renal Impairment: Icosapent ethyl has not been studied in patients with renal impairment.Hepatic Impairment: In patients with hepatic impairment, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels should be monitored periodically during therapy with Icosapent ethyl.Pediatric use: Safety and effectiveness in pediatric patients have not been established.Geriatric use: Icosapent ethyl is safe and effective in geriatric patients.