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Lubistone 24
Incepta Pharmaceuticals Ltd.
Generic: Lubiprostone
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Lubistone 24. Please consult your doctor.
CONSULT YOUR DOCTOR
Lubistone 24 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Lubistone 24 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CONSULT YOUR DOCTOR
It is not known whether Lubistone 24 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Lubistone 24 is safe to use in patients with kidney disease. No dose adjustment of Lubistone 24 is recommended.
CAUTION
Lubistone 24 should be used with caution in patients with liver disease. Dose adjustment of Lubistone 24 may be needed. Please consult your doctor.
Medicine Overview of Lubistone 24 24mcg Capsule
Introduction
Lubistone 24 is a prescription medicine used to treat constipation and irritable bowel syndrome (symptoms include abdominal pain, cramping, bloating, and diarrhea or constipation). It works by increasing the secretion of fluids in the intestine, thereby making the stool soft and easier to pass. Lubistone 24 is taken after meals to avoid nausea in a dose and duration as advised by the doctor. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications...
... Show moreUses of Lubistone 24
- Constipation
- Irritable bowel syndrome
Side effects of Lubistone 24
Common
- Nausea
- Headache
- Abdominal pain
- Abdominal distension
- Diarrhea
- Flatulence
How to use Lubistone 24
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lubistone 24 is to be taken with food.
How Lubistone 24 works
Lubistone 24 increases the secretion of fluids in the intestine, which in turn increases the motility of the intestine, thereby making the stool soft and easier to pass.
What if you forget to take Lubistone 24?
If you miss a dose of Lubistone 24, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Lubiprostone should preferably be taken with meals to reduce symptoms of nausea.
- Seek medical attention if you experience severe diarrhea, breathlessness (dyspnea) or difficulty in breathing, chest pain, tightness in chest during treatment.
- You should be thoroughly examined to confirm the absence of obstruction (e.g. gall stones, hernia, Crohn's disease, diverticulitis, polyps, impacted bowel movement etc.) before starting lubiprostone treatment.
- Lubiprostone is not recommended in children under 18 years of age.
- Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
Brief Description
Indication
Irritable Bowel Syndrome with Constipation (IBS-C), Chronic idiopathic constipation, Opioid-induced Constipation (OIC) in adults with chronic non-cancer pain
Administration
Should be taken with food.
Adult Dose
Oral
Chronic idiopathic constipation
Adult: 24 mcg bid daily.
Irritable Bowel Syndrome With Constipation
8 mcg twice daily.
Opioid-Induced Constipation
Treatment in patients with chronic noncancer pain
24 mcg bid daily.
Hepatic impairment
Mild: Dose adjustment not necessary
Moderate (Child-Pugh B): Chronic idiopathic or opioid-induced constipation, 16 mcg PO q12hr; irritable bowel syndrome with constipation (IBS-C), no dosage adjustment required
Severe (Child-Pugh C): Chronic idiopathic or opioid-induced constipation, 8 mcg PO q12hr; IBS-C, 8 mcg PO q24hr
Child Dose
Safety and efficacy not established
Contraindication
History of mechanical GI obstruction.
Mode of Action
Lubiprostone is a locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. Lubiprostone acts by specifically activating ClC-2, which is a normal constituent of the apical membrane of the human intestine. By increasing intestinal fluid secretion, Lubiprostone increases motility in the intestine, thereby facilitating the passage of stool and alleviating symptoms associated with chronic idiopathic constipation.
Precaution
Safety has not been established in pregnant women. Not to be used in patients with severe diarrhoea.
Lactation: Unknown whether drug is excreted in breast milk; because lubiprostone increases fluid secretion in the intestine and intestinal motility, monitor breastfeeding infants for diarrhea
Side Effect
>10%
Nausea (29%),Headache (12%),Diarrhea (11%)
1-10%
Edema (3%),Chest discomfort (2%),Peripheral edema (1-3%),Fatigue (2%),Dizziness (3%),Flatulence (4-6%),Abdominal distress (3%),Dyspepsia (2%),Xerostomia (1%),Abdominal pain (4-8%),Loose stools (3%)
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