The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.
Oral
Depression
Adult: As hydrochloride: 25-75 mg daily in 3 divided doses, gradually increased in 25 mg increments at 1-2 wk intervals to 150 mg/day if necessary. Up to 225 mg/day in severely depressed patients.
Elderly: Initial: 25 mg daily. May increase slowly according to response to 50-75 mg daily if needed.
Child Dose
Safety and effecay not established
Contraindication
Preexisting CV insufficiency; epilepsy or lowered seizure threshold.
Mode of Action
Maprotiline is a tetracyclic antidepressant pharmacologically similar to the tricyclic antidepressants. It's antidepressant effects appear to be due principally to inhibition of the re-uptake of noradrenaline at the neuronal membrane.
Precaution
Urinary retention, prostatic hyperplasia, chronic constipation, untreated angle-closure glaucoma; hyperthyroidism; risk of suicide; may precipitate mania or psychotic symptoms; withdraw gradually; may impair ability to operate machinery. Pregnancy and lactation; elderly.
Lactation: avoid during breastfeeding
Side Effect
Common
Fatigue,Sedation,Lethargy,Weakness,Constipation,Dry mouth,Blurred vision
Less Common
Agitation,Anxiety,Headache,Insomnia,Nausea,Vomiting,Sweating
Infrequent
Orthostatic hypotension, ECG changes, tachycardia
Confusion, EPS, dizziness, paresthesia, tinnitus
Rash,Incr LFTs,Sexual dysfunction
Rare
Seizure,Agranulocytosis,Thrombocytopenia,Eosinophilia,Leukopenia,SIADH
Potentially Fatal: Seizures
Interaction
MAOIs. Increase in sedative effect with alcohol. Increased effect of antidiabetics. Maprotiline concentrations and toxicity increased by propranolol, risperidone. Risk of seizures increased with phenothiazines.
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