The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.
Oral
Peripheral neuropathies
Adult: 1500 mcg/day in 3 divided doses.
Parenteral
Peripheral neuropathies
Adult: 500 mcg daily IM/IV 3 times/wk.
Megaloblastic anaemia caused by vitamin B12 deficiency
Adult: 500 mcg daily IM/IV 3 times/wk.
Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.
Contraindication
Hypersensitivity to any component of this product.
Mode of Action
Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
Precaution
The medicine should not be used for months if there is no response at all after its use for a certain period of time.
Side Effect
Oral: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site.
Potentially Fatal: Anaphylactoid reactions (parenteral).
Interaction
Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
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