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Medrina
Beacon Pharmaceuticals PLC
Generic: Medroxyprogesterone Acetate
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Medrina. Please consult your doctor.
UNSAFE
Medrina is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
SAFE IF PRESCRIBED
Medrina is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Nonhormonal contraceptives are preferred in breastfeeding women, especially during the first 4 weeks postpartum
UNSAFE
Medrina may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CONSULT YOUR DOCTOR
There is limited information available on the use of Medrina in patients with kidney disease. Please consult your doctor.
UNSAFE
Medrina is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Medicine Overview of Medrina 5mg Tablet
Introduction
Medrina similar to the progesterone hormone naturally produced by the body. It helps in regulating the periods, stop irregular bleeding, and for withdrawal bleeding in case of amenorrhea (unusual stopping of menstrual periods). Medrina should be taken as your doctor's advice. Your doctor will decide how much you need to take and for how much time. You may take it with or without food but better to take it at a fixed time. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include headache, abdominal pain, weakness,...
... Show moreUses of Medrina
- Abnormal uterine bleeding
- Amenorrhea
Side effects of Medrina
Common
- Headache
- Abdominal pain
- Weakness
- Dizziness
- Irregular menstrual cycle
- Nervousness
How to use Medrina
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Medrina may be taken with or without food, but it is better to take it at a fixed time.
How Medrina works
Medrina is a progestin (female hormone). It works by replacing the natural progesterone hormone that the body is unable to make. This treats painful, irregular or absent menstrual periods. It also prevents an overgrowth of the lining of the uterus in menopausal women taking oestrogen (another female hormone).
Quick Tips
- Medrina is used for a wide range of menstrual disorders such as heavy, painful or absent periods, and endometriosis.
- It may cause bleeding or spotting in between menstrual periods. Let your doctor know if this occurs frequently.
- Stop taking Medrina and inform your doctor immediately if you get severe headaches, stabbing pains or swelling in one leg, pain on breathing, sudden changes in your vision or hearing, or yellowing of your skin or whites of your eyes.
- Use a non-hormonal method of contraception such as condoms to prevent pregnancy while you are taking this medication.
- Do not take Medrina if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, stroke, heart attack, liver problems, or bleeding problems.
Brief Description
Indication
Menorrhagia, endometriosis, secondary amenorrhoea, contraception, abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology
Administration
May be taken with or without food. Incidence of minor indigestion may increase as dose increases. Take w/ meals if necessary.
Adult Dose
Oral Amenorrhea, Uterine Bleeding Uterine bleeding: 5-10 mg/day PO for 5-10 days; beginning day 16 or 21 of the menstrual cycle; withdrawal bleeding may be expected within 3 to 7 days after discontinuing medroxyprogesterone Amenorrhea, secondary: 5-10 mg/day PO for 5-10 days; may be started at any time; withdrawal bleeding may be expected within 3-7 days after discontinuing medroxyprogesterone Reduction of endometrial hyperplasia: 5 or 10 mg daily for 12 to 14 consecutive days per month, in postmenopausal women receiving daily 0.625 mg conjugated estrogens, either beginning on the 1st day of the cycle or the 16th day of the...
... Show moreContraindication
Thromboembolic disorders; cerebral apoplexy; severe hepatic dysfunction; incomplete abortion, hormone-dependent carcinoma; Undiagnosed vaginal bleeding, Undiagnosed urinary tract bleeding, Known or suspected pregnancy, Undiagnosed breast pathology, Missed abortion, Active thromboembolic disorders, Markedly impaired liver function,
Mode of Action
Medroxyprogesterone is a synthetic progestogen which converts the proliferative phase of the endometrium into secretory phase. It has some androgenic and anabolic activities but no oestrogenic effects. Parenteral use leads to inhibition of pituitary gonadotropins, thus preventing follicular maturation and ovulation.
Precaution
Breakthrough bleeding is likely to occur in patients being treated for endometriosis. May cause some degree of fluid retention, conditions which might be influenced by this factor, such as epilepsy, migraine, asthma, or cardiac or renal dysfunction, require careful observation. A decrease in glucose tolerance has been observed in some patients. Patients with depression, DM, epilepsy, asthma, migraine, hypertension, renal or cardiac dysfunction. Monitor patient closely for loss of vision, proptosis, diplopia and thromboembolic disorders.
Lactation: Safe
Side Effect
>10%
Amenorrhea,Breakthrough bleeding,Change in menstrual flow,Spotting,Edema,Anorexia,Weakness,Pain at injection site
Frequency Not Defined
Angioedema,Change in weight,Depression,Dizziness,Headache,Nervousness,Somnolence,Breast tenderness,Galactorrhea,Abdominal pain,Nausea and vomiting,Cholestatic jaundice,Deep vein thrombosis (DVT),Thrombophlebitis
Potentially Fatal: Thrombophlebitis and pulmonary embolism.
Interaction
Aminoglutethimide and enzyme-inducing drugs (e.g. carbamazepine, griseofulvin, phenobarbital, rifampicin, phenytoin) may reduce plasma concentrations leading to reduced efficacy. Additional measures required when medroxyprogesterone is used for contraception during coadministration with these drugs.
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