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Megacilin
Popular Pharmaceuticals Ltd.
Generic: Piperacillin + Tazobactam
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Megacilin does not cause any harmful side effects.
SAFE IF PRESCRIBED
Megacilin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Megacilin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
CONSULT YOUR DOCTOR
It is not known whether Megacilin alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Megacilin should be used with caution in patients with kidney disease. Dose adjustment of Megacilin may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Megacilin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Megacilin may not be needed in these patients. Please consult your doctor.
Medicine Overview of Megacilin 4gm+0.5gm/vial Injection
Introduction
Megacilin is a combination of two antibiotics. It is used to treat various types of bacterial infections. It fights against the infection by killing the microorganisms. Megacilin is generally administered by a healthcare professional and should not be self-administered. Depending on the severity of your underlying illness, your doctor will decide the precise dose and schedule as per which this injection is to be given. It is strictly advised to be used as per the doctor's prescription. Some of the common side effects of this medicine include nausea, vomiting, diarrhea, and rash. Additionally, you may notice some injection site reactions...
... Show moreUses of Megacilin
- Bacterial infections
Side effects of Megacilin
Common
- Nausea
- Vomiting
- Diarrhea
- Rash
- Allergic reaction
How to use Megacilin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Megacilin works
Megacilin is a combination of two medicines: Piperacillin and Tazobactum. Piperacillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Tazobactum is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Piperacillin against bacteria.
Quick Tips
- You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect. Taking probiotics along with Megacilin may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
- Stop taking Megacilin and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
Brief Description
Indication
Septicaemia, Nosocomial pneumonia
Administration
Reconstitution
Reconstitute initially (2.25 g in 10 mL, 4.5 g in 20 mL) w/ water for inj, glucose 5% or NaCl 0.9%, then further dilute to 50-150 mL w/ compatible infusion soln.
IV Administration
Infusion over 30 min
Adult Dose
Intravenous Nosocomial pneumonia Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 6 hrly for 5-14 days by infusion over 30 min. When used empirically, combination w/ aminoglycoside or antipseudomonal fluoroquinolone is recommended. Empiric therapy for febrile neutropenic patients Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 6 hrly for 5-14 days by infusion over 30 min. Complicated intra-abdominal infections Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 8 hrly for 5-14 days by infusion over 30 min. Complicated urinary...
... Show moreChild Dose
Intravenous
Child: Usually 12 yr Same as adult dose.
Empiric therapy for febrile neutropenic patients
Child: 2-12 yr 90 mg/kg (piperacillin 80 mg/kg and tazobactam 10 mg/kg) 6 hrly for 5-14 days by infusion over 30 min.
Max: 4.5 g per dose; >12 yr Same as adult dose.
Complicated intra-abdominal infections
Child: 2-12 yr 112.5 mg/kg (piperacillin 100 mg and tazobactam 12.5 mg) 8 hrly for 5-14 days by infusion over 30 min.
Max: 4.5 g per dose.
Renal Dose
Renal impairment: Haemodialysis patients: 2.25 g 12 hrly; additional dose of 0.75 g after each dialysis session. CAPD: 2.25 g 12 hrly.
CrCl (ml/min) Dosage Recommendation
<20 2.25 g 8 hrly.
20-40 2.25 g 6 hrly.
Contraindication
Hypersensitivity.
Mode of Action
Piperacillin has an antimicrobial activity against a wide range of gm-ve organisms including K. pneumoniae, P. aeruginosa, Enterobacteriaceae and against gm+ve organisms eg E. faecalis and B. fragilis. Tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties. In combination, tazobactam enhances the activity of piperacillin against beta-lactamase-producing bacteria.
Precaution
Pregnancy and lactation, pseudomembranous colitis. Assess hematopoietic function periodically. Perform periodic electrolyte determinations in patients with low K reserves. Increased risk of fever and rash in patients with cystic fibrosis. Increased risk of bleeding manifestations. Prolonged treatment may increase risk of superinfections. Convulsions or neuromuscular excitability may occur when high doses are used, especially in renally impaired patients. Renal impairment.
Lactation: Low concentrations of piperacillin excreted in breast milk; tazobactam unknown; use caution
Side Effect
>10%
Diarrhea (7-11%)
1-10%
Constipation (1-8%),Headache (1-8%),Insomnia (4-7%),Nausea (2-7%),Fever (2-5%),Oral candidiasis (2-4%),Rash (2-4%),Vomiting (2-4%),Dyspepsia (3%),Pruritus (3%),Pain (2-3%),Hypertension (2%),Leukopenia (1%),Thrombocytopenia (1.4%)
<1%
Anaphylaxis,Agranulocytosis,Thrombocytopenia,Eosinophilia,Leukopenia,Positive Coombs test,Prolonged PT and PTT,Transient LFT and creatinine elevations.Seizure,Pulmonary edema,Pulmonary embolism
Interaction
Interacts w/ high doses of heparin, oral anticoagulants or other drugs that affect blood coagulation or thrombocyte function. Prolongs the neuromuscular blockade of vecuronium and non-depolarising muscle relaxants. Prolongs half-lives w/ probenecid. Increased risk of methotrexate toxicity.
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