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Megapime IV/IM
Eskayef Pharmaceuticals Ltd.
Generic: Cefepime
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Megapime IV/IM does not cause any harmful side effects.
SAFE IF PRESCRIBED
Megapime IV/IM is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Megapime IV/IM is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoid prolonged use of Megapime IV/IM, since it may have possible effects such as rash and diarrhea.
CONSULT YOUR DOCTOR
It is not known whether Megapime IV/IM alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Megapime IV/IM should be used with caution in patients with kidney disease. Dose adjustment of Megapime IV/IM may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Megapime IV/IM is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Megapime IV/IM may not be needed in these patients. Please consult your doctor.
Medicine Overview of Megapime IV/IM 500mg/vial Injection
Introduction
Megapime IV/IM is an antibiotic that fights bacteria. It is used to treat severe bacterial infections of the skin, lungs, stomach, urinary tract, and blood. It works by killing the bacteria that cause these problems. However, it will not treat a viral infection. Megapime IV/IM is commonly used to treat critically ill patients admitted to the hospital. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should...
... Show moreUses of Megapime IV/IM
- Bacterial infections
Side effects of Megapime IV/IM
Common
- Rash
- Itching
- Nausea
- Vomiting
- Headache
- Fever
- Diarrhea
How to use Megapime IV/IM
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Megapime IV/IM works
Megapime IV/IM is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Megapime IV/IM?
If you miss a dose of Megapime IV/IM, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Megapime IV/IM to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Discontinue Megapime IV/IM and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Avoid consuming alcohol while taking Megapime IV/IM as it may cause increased side effects.
Brief Description
Indication
Skin and skin structure infections, Urinary tract infection, Nosocomial pneumonia, Multiple drug resistant pneumonia, Neutropenia
Administration
Reconstitution: IV infusion: Add 5 mL, 10 mL, or 10 mL of a compatible IV soln to a vial labeled as containing 500 mg, 1 g, or 2 g, respectively, to provide soln containing approx 100 mg/mL, 100 mg/mL, or 160 mg/mL of the drug, respectively. The appropriate dose of the drug should then be added to a compatible IV soln. IM inj: Add 1.3 mL or 2.4 mL of an appropriate diluent (e.g. sterile water for inj, NaCl 0.9%) to a vial labeled as containing 500 mg or 1 g respectively, to provide a soln containing approx 280 mg/mL....
... Show moreAdult Dose
Adult: IV UTI 0.5-1 g 12 hrly for 7-10 days.
Empirical therapy for febrile neutropenia 2 g 8 hrly for 7 days or until resolution of neutropenia.
Moderate to severe pneumonia 1-2 g 12 hrly for 10 days.
Complicated intra-abdominal infections 2 g 12 hrly for 7-10 days.
Uncomplicated skin and skin structure infections 2 g 12 hrly for 10 days.
Child Dose
Child: IV, IM 100 mg/kg/day q12h
150 mg/kg/day empiric therapy of fever with neutropenia q8h
2 mth - 16 yr: >40 kg: 50 mg/kg every 12 hr for 7-10 days for Uncomplicated and Complicated Urinary Tract Infections (including pyelonephritis),
Uncomplicated Skin and Skin Structure Infections and Pneumonia.. May be given via direct inj over 5 minutes or infuse over 30 minutes.
For empiric therapy for febrile neutropenic patients 2 mth - 16 yr: <40 kg: 50 mg/kg every 8 hr for 7 days or until neutropenia resolves.
Renal Dose
Renal impairment:
Haemodialysis: 1 g on the 1st day of treatment, followed by 0.5 g 24 hrly; dose should be given after haemodialysis on dialysis days and preferably at the same time each day.
CAPD: Adult dose 48 hrly.
CrCl (ml/min)
<10 0.25-0.5 g 24 hrly.
11-29 0.5-1 g 24 hrly.
30-60 0.5-2 g 24 hrly.
Contraindication
Hypersensitivity to cefepime or other cephalosporins.
Mode of Action
Cefepime is a 4th generation cephalosporin which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs).
Precaution
Renal impairment; history of penicillin or cephalosporin allergy; lactation, pregnancy. Caution when used in patients with history of GI diseases, especially colitis. May decrease prothrombin activity; monitor prothrombin time in patients with poor nutritional state, renal or hepatic impairment and those on prolonged treatment. Prolonged treatment may result in overgrowth of nonsusceptible organisms, resulting in superinfection. Consider the possibility of Clostridium difficile associated diarrhoea in patients who present with diarrhoea after treatment. Caution when used in patients with a history of seizures.
Lactation: Drug enters breast milk; use with caution
Side Effect
>10%
Positive Coombs test result without hemolysis (16%)
1-10%
Rash (1-4%),Elevated alanine aminotransferase (3%),Hypophosphatemia (3%),Diarrhea (<3%),Eosinophilia (2%),Erythema at injection site (2%),Normal partial thromboplastin time (PTT) (2%),Nausea or vomiting (<2%),Fever (1%),Headache (1%),Pain (1%),Pruritus (1%)
<1%
Agranulocytosis,Anaphylactic shock,Anaphylaxis,Coma,Encephalopathy,Hallucinations,Leukopenia,Myoclonus,Neuromuscular excitability,Neutropenia,Seizures,Thrombocytopenia
Pregnancy Category Note
Pregnancy category: B
Lactation: Drug enters breast milk; use with caution
Interaction
Increased potential for nephrotoxicity and ototoxicity of aminoglycosides. Increased risk of nephrotoxicity w/ potent diuretics (e.g. furosemide).
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