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Megatrim
Beximco Pharmaceuticals Ltd.
Generic: Sulphamethoxazole + Trimethoprim (Co-trimoxazole)
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Megatrim. Please consult your doctor.
CONSULT YOUR DOCTOR
Megatrim is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Megatrim is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
There may be a possibility of skin rash in the baby.
CONSULT YOUR DOCTOR
It is not known whether Megatrim alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Megatrim should be used with caution in patients with kidney disease. Dose adjustment of Megatrim may be needed. Please consult your doctor.
Use of Megatrim is not recommended in patients with severe kidney disease.
CAUTION
Megatrim should be used with caution in patients with liver disease. Dose adjustment of Megatrim may be needed. Please consult your doctor.
Use of Megatrim is not recommended in patients with the severe liver disease.
Medicine Overview of Megatrim 800mg+160mg Tablet
Introduction
Megatrim is a combination medicine that is used to treat various types of bacterial infections such as pneumonia, bronchitis, infections of urinary tract, ear, and abdomen. It prevents the growth of microorganisms to cure the infection. Megatrim is a prescription medicine that is advised to be taken as suggested by the doctor. It should be taken with food and it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as an overdose of it may have harmful effects on your body. If you miss a dose, take it as soon...
... Show moreUses of Megatrim
- Bacterial infections
Side effects of Megatrim
Common
- Nausea
- Vomiting
- Skin rash
- Allergic reaction
How to use Megatrim
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Megatrim is to be taken with food.
How Megatrim works
Megatrim is a combination of two antibiotics: Sulfamethoxazole and Trimethoprim. These antibiotics work by preventing the bacteria from producing folic acid, a nutrient required for bacterial multiplication. Together, they treat your infection effectively.
Quick Tips
- You have been prescribed Megatrim for the treatment of many types of bacterial infections.
- Finish the prescribed course of Megatrim, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Stop taking Megatrim and inform your doctor if you develop skin rash/blisters or other unexplained skin reaction while taking Megatrim.
- In case of long-term use, have regular monthly blood tests to monitor your blood cells as suggested by your doctor.
Brief Description
Indication
Upper and lower respiratory tract infections, Gastrointestinal tract infections, Renal and urinary tract infections, Skin and wound infections, Septicaemias
Adult Dose
Oral Acute exacerbations of chronic bronchitis ; Acute otitis media; Urinary tract infections, GI infections; Resp and urinary tract infections; Susceptible infections Adult: Tablet : 2 tablet of 480mg twice daily. In severe cases, 3 times/day. DS Tablet : 1 tablet (960mg) twice daily. Suspension : 1-2 teaspoonful twice daily. Pneumocystis (carinii) jiroveci pneumonia Up to 120 mg/kg/day in 2-4 divided doses for 14-21 days. Prophylaxis of Pneumocystis (carinii) jiroveci pneumonia 960 mg once daily for 7 days; 960 mg once daily 3 times wkly on alternate days; or 960 mg bid 3 times wkly on alternate days. Infection prophylaxis...
... Show moreChild Dose
Child:
Oral
8–10 mg TMP/kg/day q12h
2 mg TMP/kg/day for UTI prophylaxis q24h
15–20 mg TMP/kg/day for Pneumocystis (carinii) jiroveci pneumonia treatment q6–8h
150 mg TMP/m2/day, OR 5 mg TMP/kg/day for Pneumocystis (carinii) jiroveci pneumonia prophylaxis q12h, 3 times a week OR q24h
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<15 Not recommended.
15-30 Half the standard dose.
Contraindication
Known hypersensitivity to trimethoprim or sulfonamides; severe hepatic failure or marked liver parenchymal damage, jaundice; serious haematological disorders and porphyria; severe renal insufficiency where repeated measurements of the plasma concentration cannot be performed; history of drug-induced immune thrombocytopenia w/ use of trimethoprim and/or sulfonamides; megaloblastic anaemia due to folate deficiency. Neonates 4 wk. Treatment of Group A β-haemolytic streptococcia. Pregnancy, esp in the period prior to birth. Concomitant use w/ clozapine. Concomitant use w/ leucovorin for the treatment of P. jiroveci in HIV positive patients.
Mode of Action
Co-trimoxazole exhibits the synergistic actions of its components (sulfamethoxazole and trimethoprim) by 10-fold. Sulfamethoxazole inhibits dihydrofolic acid formation from PABA, thus interfering with synthesis and growth of bacterial folic acid. Trimethoprim inhibits enzymes folic acid pathway, preventing the reaction of the dihydrolic acid to tetrahydrofolate. Co-trimoxazole possesses bactericidal effects against E coli, Klebsiella spp, Enterobacter spp, M morganii, P mirabilis, P vulgaris, H influenzae, Strep pneumoniae, Pneumocystis (carinii) jiroveci, Cyclospora spp.
Precaution
Patient w/ severe allergy, bronchial asthma, thyroid dysfunction. Renal and mild to moderate hepatic impairment. Lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor CBC, serum K, creatinine, BUN.
Side Effect
Allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch-Schoenlein purpura, serum sickness-like syndrome, generalised allergic reactions, generalised skin eruptions, photosensitivity, conjunctival and scleral inj, pruritus, urticaria, rash, periarteritis nodosa, SLE; elevated serum transaminase and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhoea, anorexia; renal failure, interstitial nephritis, elevated BUN and serum creatinine, toxic nephrosis w/ oliguria and anuria; hyperkalaemia; aseptic meningitis, convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache; hallucinations, depression, apathy, nervousness; dieresis, hypoglycaemia; arthralgia, myalgia; rhabdomyolysis; cough, shortness of breath, pulmonary infiltrates; weakness, fatigue, insomnia; QT prolongation, haemolysis, impaired phenylalanine metabolism. Potentially Fatal: Severe...
... Show moreInteraction
Reduced ciclosporin concentrations in blood when used concurrently. Increases toxicity of methotrexate. Inhibits phenytoin clearance. Potentiates warfarin and oral hypoglycaemics.
Potentially Fatal: Co-admin with pyrimethamine causes megaloblastic anaemia. Enhancement of renal damage by ciclosporin.
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