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Melev 20
Beximco Pharmaceuticals Ltd.
Generic: Paroxetine Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Melev 20.
UNSAFE
Melev 20 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Melev 20 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Melev 20 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Melev 20 should be used with caution in patients with kidney disease. Dose adjustment of Melev 20 may be needed. Please consult your doctor.
CAUTION
Melev 20 should be used with caution in patients with liver disease. Dose adjustment of Melev 20 may be needed. Please consult your doctor.
Medicine Overview of Melev 20mg Tablet
Introduction
Melev 20 is a type of antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) group of medicines. It is widely prescribed to treat depression and anxiety-related conditions like panic disorder, obsessive-compulsive disorder, and post traumatic stress disorder (PTSD). Melev 20 helps many people to recover from depression by improving their mood and relieving anxiety and tension. It can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you on a lower dose and...
... Show moreUses of Melev 20
- Depression
- Obsessive-compulsive disorder
- Post traumatic stress disorder
- Panic disorder
- Anxiety
Side effects of Melev 20
Common
- Delayed ejaculation
- Low sexual desire
- Nausea
- Tremor
- Confusion
- Dizziness
- Dryness in mouth
- Erectile dysfunction
- Fatigue
- Increased sweating
- Insomnia (difficulty in sleeping)
- Loss of appetite
- Nervousness
- Sleepiness
How to use Melev 20
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Melev 20 may be taken with or without food, but it is better to take it at a fixed time.
How Melev 20 works
Melev 20 is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of post traumatic stress disorder, panic disorder, anxiety and obsessive-compulsive disorder.
Quick Tips
- It can take 2-3 weeks for Pexep CR 12.5 Tablet to start working.
- Do not stop treatment suddenly as this may cause upset stomach, flu-like withdrawal symptoms and sleep disturbance.
- If your doctor asks you to stop Pexep CR 12.5 Tablet, you should reduce the dose slowly over 4 weeks.
- Avoid consuming alcohol when taking Pexep CR 12.5 Tablet, as it may cause excessive drowsiness and calmness.
- The addiction/dependence potential of Pexep CR 12.5 Tablet is very less.
Brief Description
Indication
Depression, Anxiety, Panic disorder, Obsessive-compulsive disorder, Posttraumatic stress disorder, Social anxiety disorder, Premenstrual dysmorphic disorder
Administration
May be taken with or without food. May be taken w/ meals to minimise GI upset.
Adult Dose
Oral
Depression, Anxiety, Posttraumatic stress disorder
Adult: 20 mg daily, increase gradually, if necessary, by 10-mg increments wkly; max: 50 mg/day.
Obsessive compulsive disorder, Social anxiety disorder
Adult: Initially, 20 mg daily, increase wkly in 10-mg increments. Maintenance: 40-60 mg daily.
Panic disorder with or without agoraphobia
Adult: Initially, 10 mg daily, increase wkly in 10-mg increments according to clinical response. Maintenance: 40-60 mg daily.
Elderly: Initially, 10 mg daily, increase if needed by 10 mg/day at 1 wk intervals; max: 40 mg daily.
Hepatic impairment: Severe: 10 mg daily, increase to a max of 40 mg daily as necessary.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Severe: 10 mg daily, increase to a max of 40 mg daily as necessary.
Contraindication
Use with or within 14 days of MAOIs; concurrent use with thioridazine or pimozide.
Mode of Action
Paroxetine selectively inhibits the reuptake of serotonin. It has limited direct action at other neurotransmitter sites including muscarinic receptors.
Precaution
Epilepsy, glaucoma, history of mania, cardiac disease, DM, history of bleeding disorders, on drugs with increased risk of bleeding; renal and hepatic impairment; patients receiving electroconvulsive therapy; achlorhydria or high gastric pH (reduced absorption of oral suspension). Pregnancy and lactation. The risk of suicidal behaviour may be higher in young adults, closely monitor. May impair ability to drive or perform tasks. Avoid abrupt withdrawal.
Lactation
Excreted in breast milk; use caution (AAP states effect on nursing infants is unknown but may be of concern)
Side Effect
>10% (Based on 40 mg Dose)
Nausea (15-24%),Insomnia (11-24%),Dry mouth (9-18%),Headache (17%),Asthenia (10-15%),Constipation (10-15%),Diarrhea (9-12%),Dizziness (6-14%),Ejaculation disorder (10-15%),Tremor (4-11%),
1-10% (Based on 40 mg Dose)
Anxiety (5-10%),Blurred vision (5-10%),Decreased appetite (5-10%),Impotence (2-9%),Nervousness (2-5%),Paresthesia (2-5%),Hypomania (0.3 to 2.2%)
Frequency Not Defined (Based on 40 mg Dose)
Hypertension,Tachycardia,Emotional lability,Pruritus,Weight gain,Arthralgia,Tinnitus.Vertigo.Angle clossure glaucoma
Serious
Depression exacerbation,Mania (rare),Serotonin syndrome,Suicidal thoughts (rare),Suicide (rare),Seizure (rare),Toxic epidermal necrolysis,Hyponatremia (rare),Bleeding, abnormal (rare).Acute hepatitis (rare).Stevens-Johnson Syndrome
Interaction
Levels/effects inhibited by cyproheptadine, phenytoin. Levels/effects increased by carbamazepine, cimetidine, CYP2D6 inhibitors (e.g. chlorpromazine, delavirdine, fluoxetine, miconazole, pergolide, quinidine, quinine, ritonavir, ropinirole). Increases levels/effects of atomoxetine, carvedilol, clozapine, CYP2B6 substrates (e.g. bupropion, promethazine, propofol, selegiline, sertraline), CYP2D6 substrates (e.g. amphetamines, selected beta-blockers, dextromethorphan, fluoxetine, lidocaine, mirtazapine, nefazodone, risperidone, ritonavir, thioridazine, TCAs, venlafaxine), duloxetine, galantamine, mexilitine, pimozide, procyclidine, propafenone. Decreases levels/effects of CYP2D6 prodrug substrates (e.g. codeine, hydrocodone, oxycodone, tramadol). Inhibits the metabolism of dextromethorphan, haloperidol, thioridazine. Enhances bradycardic effect of beta-blockers. Enhances toxic effects of other CNS depressants. Increased risk of serotonin syndrome with amphetamines, SSRIs, meperidine, nefazodone, trazodone, serotonin...
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