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Mesacol 400
Sun Pharmaceutical (Bangladesh) Ltd.
Generic: Mesalazine [5-aminosalicylic acid]
Safety Advices
বাংলা
English
UNSAFE
Taking Mesacol 400 Tablet with alcohol can increase the risk of stomach upset and bleeding. Avoid alcohol while taking Mesacol 400 Tablet
CONSULT YOUR DOCTOR
Mesacol 400 Tablet has been shown to cross the placenta and may cause harm to the fetus. It should be given in pregnancy only if the potential benefit justifes the potential risk to the fetus.
CAUTION
Mesacol 400 Tablethas been shown to pass into breast milk that’s why should take caution to take it. Caution is advised when it is administered to a nursing mother.
SAFE
Mesacol 400 Tabletis generally considered safe to take while driving. If there is any problem during driving, stop taking it.
CAUTION
Mesacol 400 Tablet should be used with caution in patients who have known renal dysfunction or have a history of renal disease.
CAUTION
Patients with liver disease should use Mesacol 400 Tablet with caution. The liver helps to break down Mesacol 400 Tablet and people with liver disease may have higher levels of 5-aminosalicylic acid (mesalazine) in their blood. This can increase the risk of side effects.
Medicine Overview of Mesacol 400mg Tablet
Introduction
Mesacol 400 Tabletis a anti-inflammatory agents used to treat inflammatory bowel disease and some forms of arthritis. Mesacol 400 Tabletwork by inhibiting the production of cyclo-oxygenase and prostaglandin, thromboxane synthetase, platelet activating factor synthetase, and interleukin-1 by macrophages so reduces the acute inflammatory response in inflammatory bowel disease.
Uses of Mesacol 400
Mesacol 400 Tabletuse as a treatment of inflammatory bowel disease (IBD) ,including ulcerative colitis and Crohn's disease.
Side effects of Mesacol 400
- Stomach upset
- Nausea
- Diarrhea
- Headaches
- Vomiting
- Abdominal pain
- Skin rash
How to use Mesacol 400
Mesacol 400 Tablet is usually take will depend on the severity of pataient condition and individual needs. It is important to take the medication exactly as prescribed by your doctor.Do not crush, chew, or break the tablet.Mesacol 400 Tablet may be taken on an empty or full stomach. However, taking it with to reduce the risk of stomach upset.
How Mesacol 400 works?
Mesacol 400 Tablet works by diminishes infammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.
What if you forget to take Mesacol 400 ?
Take Mesacol 400 Tabletas soon as you remember .If it is almost time for your next dose, skip the missed dose and take next dose at the regular time. Do not take two doses at the same time.
Brief Description
Indications
Treatment of mild to moderately active Ulcerative Colitis & Crohn’s Disease. Maintenance of remission of Ulcerative Colitis. Maintenance of remission of Crohn’s disease.
Administration
Swallow the tablets or capsules whole with a glass of water .The granules must not be chewed. The contents of the sachet should be emptied onto the tongue and washed down with some water.
Adult Dose
Ulcerative colitis- Adults: Active disease: Individual dosage, up to 4 gm once daily or divided into 2-4 doses. Maintenance treatment: Individual dosage. Recommended dosage, 2 gm once daily. Geriatrics: Patients who are 65 years or older, caution should be taken to closely monitor blood cell counts during Mesalamine therapy.
Child Dose
Pediatrics: The safety and efficacy in children below 6 years of age have not been established. There is only limited documentation for an effect in children (age 6-18 years). Children 6 years of age and older: Active disease: To be determined individually, starting with 30-50 mg/kg/day in divided doses. Maximum dose: 75 mg/kg/day in divided doses. The total dose should not exceed 4 g/day (maximum adult dose). Maintenance treatment: To be determined individually, starting with 15-30 mg/kg/day in divided doses. The total dose should not exceed 2 g/day (recommended adult dose). It is generally recommended that half the adult dose...
... Show moreRenal Dose
Elderly patients are more likely to have decreased renal function, 5-aminosalicylic acid ( mesalazine) should be used with care.
Contraindication
Not recommended for patients who have a known hypersensitivity to salicylates or to any other component of the formulation.
Mode of Action
It appears to work by blocking the production of inflammatory chemicals in the intestines. This helps to reduce inflammation and improve symptoms of IBD, including ulcerative colitis and Crohn's disease..
Precautions
Inform your doctor about all medications you are taking, including prescription, over-the-counter, and herbal supplements. Some medications may interact with 5-aminosalicylic acid (mesalazine), increasing the risk of side effects. Drink plenty of fluids while taking 5-aminosalicylic acid (mesalazine). This will help an avoid dehydration and kidney problems. Do not take 5-aminosalicylic acid (mesalazine) if you are allergic to it or to other aminosalicylates.
Side Effect
The commonly reported adverse events are headache, nausea, dizziness, asthenia, dyspepsia, vomiting, pruritus etc. Other potential side effects of 5-aminosalicylic acid (mesalamine) include: Kidney problems, Liver problems, Pancreatitis, Hair loss, Joint pain, Fever, Fatigue, Loss of appetite, Weight loss.
Pregnancy & Lactation Category Note
Pregnancy: It should be given during pregnancy only if the potential benefit justifies the risk to the fetus. Lactation: It should be used during breastfeeding only if the potential benefits outweigh the potential risks. 5-aminosalicylic acid (mesalazine) has been shown to pass into breast milk. A lactating mother should be advised to exercise caution.
Interaction
Concurrent use of other known nephrotoxic agents such as NSAIDs and Azathioprine may increase the risk of renal reaction
Storage Conditions
Store below 30°C . Protect from light and moisture. Keep all medicines out of the reach of children.
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