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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Mesna. Please consult your doctor.
SAFE IF PRESCRIBED
Mesna is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
UNSAFE
Mesna is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Mesna may cause side effects which could affect your ability to drive.
As patients undergoing treatment with Mesna may experience undesirable effects such as lightheadedness, lethargy, dizziness, and blurred vision which could affect the ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Mesna in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Mesna in patients with liver disease. Please consult your doctor.
Medicine Overview of Mesna 400mg/4ml Injection
Introduction
Mesna is used to prevent ifosfamide-induced hemorrhagic cystitis. But, its not used to reduce the risk of blood in the urine due to other medical conditions. It only helps to reduce the risk of inflammation and bleeding in the bladder, who receive ifosfamide. Mesna is given under the supervision of doctor. It is taken in a dose as advised by the doctor. The duration of treatment varies on the basis of your need and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very...
... Show moreUses of Mesna
- Ifosfamide-induced hemorrhagic cystitis
Side effects of Mesna
Common
- Nausea
- Headache
- Lightheadedness
- Lethargy
- Abdominal pain
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Diarrhea
- Rash
- Fever
- Flu-like symptoms
How to use Mesna
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Mesna works
Mesna helps to reduce the risk of inflammation and bleeding in the bladder, who receive ifosfamide (a medicine used to treat cancer).
Quick Tips
- Drink at least 1 litre of fluid daily while you are receiving mesna.
- Seek immediate medical attention if you experience severe allergic reactions like rash, itching, breathing difficulty, chest tightness, and swelling of the mouth, face, lips, or tongue while taking mesna.
- Do not drive or operate machinery as mesna may cause drowsiness, dizziness, blurred vision, or light headedness.
- Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
- You will be monitored for blood or protein in urine during the treatment of mesna.
- Do not take if allergic to mesna or any of its ingredients (thiol containing compound)
Brief Description
Indication
Urothelial toxicity
Administration
IV Preparation
Reconstitute w/ D5W, NS, dextrose/saline or LR to a final concentration of 20 mg/mL
IV Administration
IVP: bolus 15 min before ifosfamide
Intermittent infusion over 15-30 min
Continuous Infusion: may be added to ifosfamide/cyclophosphamide in infusion bag
Additive compatibility w/ cyclophosphamide shown only in D5W & LR
Adult Dose
Intravenous
Prophylaxis against urothelial toxicity
With Ifosfamide
240 mg/sq.meter (if receiving 1.2 g/sq.meter ifosfamide dose) IVP 15 minutes before & 4 & 8 hours after ifosfamide admin OR
240 mg/sq.meter (if receiving 1.2 g/sq.meter ifosfamide dose) IVP 15 minutes before & 480 mg/sq.meter PO 2 & 6 hours after ifosfamide admin
Adjust dose accordingly if ifosfamide dose changes
Also given by alternative IVP regimens, intermittent infusion or continuous infusion-
Contraindication
Hypersensitivity to thiol-containing compounds.
Mode of Action
Mesna is used to prevent urothelial toxicity associated with oxazaphosphorine, ifosfamide or cyclophosphamide. It acts in the kidney; reacting with thiol groups of urotoxic metabolites (e.g. acrolein) of ifosfamide and cyclophosphamide. It is used as a mucolytic in the management of some respiratory tract conditions e.g. cystic fibrosis where other mucolytics have failed. It acts by reducing the viscosity of pulmonary secretions; the drug's free sulfhydryl group is thought to reduce disulfide linkages of mucoproteins.
Precaution
Protective effect applies only to the urinary tract; pregnancy, lactation. Patients with auto-immune disorders. IV formulation may contain benzyl alcohol as a preservative; avoid in neonates or infants. Instruct patients to seek medical attention if discolouration of urine occurs. During treatment, monitor urine for erythrocytes and haematuria. Maintain adequate hydration in all patients. Patients who vomit within 2 hr of oral dose should repeat dose or receive IV dose.
Lactation: not known if excreted in breast milk, do not nurse
Side Effect
>10%
Nausea (>50%),Vomiting (29%),Anorexia.Asthenia,Fatigue,Fever,Abdominal pain,Constipation,Anemia,Granulocytopenia,Leukopenia,Thrombocytopenia,Alopecia
1-10%
Anxiety,Confusion,Dizziness,Headache,Insomnia,Pain,Somnolence,Chest pain,Edema,Flushing,Tachycardia,Cough,Dyspnea,Pneumonia,Diarrhea,Hematuria,Hypokalemia,Back pain,Dehydration,Injection site reaction,Pallor
Potentially Fatal: May cause haemorrhagic cystitis, systemic anaphylactic reactions.
Interaction
Mesna is incompatible in vitro with cisplatin and nitrogen mustard.
