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Metadaxan
Incepta Pharmaceuticals Ltd.
Generic: Dexamethasone Sodium Phosphate
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Metadaxan. Please consult your doctor.
CONSULT YOUR DOCTOR
Metadaxan may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Metadaxan is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Metadaxan does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Metadaxan is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Metadaxan may not be needed in these patients. Please consult your doctor.
Regular monitoring of kidney function tests and other blood tests is advisable while you are taking Metadaxan.
CAUTION
Metadaxan should be used with caution in patients with liver disease. Dose adjustment of Metadaxan may be needed. Please consult your doctor.
Medicine Overview of Metadaxan 5mg/ml Injection
Introduction
Metadaxan belongs to a group of medicines called steroids. It is used in the treatment of various diseases and conditions (such as severe allergic reactions, asthma, rheumatic disorder, skin disorders and eye disorders). Metadaxan provides relief from swelling, redness, pain, and itching in the affected area by preventing the release of substances that cause inflammation. It is given by a healthcare professional and should not be self-administered. You need to use it regularly to get the maximum benefit of the medicine. The most common side effects of this medicine include injection site reactions (pain, swelling, redness) and mood changes. If...
... Show moreUses of Metadaxan
- Allergic conditions
- Severe allergic reactions
- Asthma
- Cancer
- Rheumatic disorder
- Skin disorders
- Eye disorders
- Nephrotic syndrome
Side effects of Metadaxan
Common
- Injection site reactions (pain, swelling, redness)
- Mood changes
How to use Metadaxan
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Metadaxan works
Metadaxan is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.
Quick Tips
- Metadaxan helps treat inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems that require either reduction of inflammation or suppression of the immune system.
- Do not use it more often or for longer than advised by your doctor.
- Metadaxan can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.
- Side effects such as mood changes or stomach problems can happen when you start taking Metadaxan. Inform your doctor if this bothers you.
- Do not stop taking Metadaxan suddenly without talking to your doctor first as it may worsen your symptoms.
Brief Description
Indication
Ulcerative colitis, Rheumatoid arthritis, Multiple sclerosis, Nausea and vomiting, Multiple myeloma, Cerebral oedema, Shock, Inflammatory joint diseases, Idiopathic thrombocytopenic purpura, Dental surgery, Allergic anaphylactic shock, Brain tumors, Status asthmaticus
Administration
IV Preparation
Standard diluent: 4 mg/50 mL D5W or 10 mg/50 mL D5W
Minimum volume: 50 mL D5W
IV/IM Administration
Dexamethasone sodium phosphate: Administered by IV push, continuous or intermittent IV infusion, or IM
Adult Dose
Dexamethasone sodium phosphate injection, – For intravenous, intramuscular, intra-articular, intralesional, and soft tissue injection.
Dexamethasone can be given parenterally at doses of 0.5-20 mg daily, either as a single IV/IM injection or by IV infusion.
Cerebral Edema
10 mg IV, then 4 mg IM q6hr until clinical improvement is observed; may be reduced after 2-4 days and gradually discontinued over 5-7 days
Shock
1-6 mg/kg IV once or 40 mg IV q2-6hr PRN
Alternative: 20 mg IV, then 3 mg/kg/day by continuous IV infusion
High-dose treatment not to be continued beyond 48-72 hours
Child Dose
Airway Edema
0.5-2 mg/kg/day IV/IM divided q6hr, starting 24 hours before extubation and continued for 4-6 doses afterward
Croup
0.6 mg/kg IV/IM once; not to exceed 16 mg
Inflammation
0.08-0.3 mg/kg/day IV/IM divided q6hr or q12hr
Meningitis
>6 weeks: 0.6 mg/kg/day IV divided q6hr for first 2-4 days of antibiotic therapy, starting 10-20 minutes before or simultaneously with first antibiotic dose
Cerebral Edema Associated With Brain Tumor
1-2 mg/kg IV/IM once; maintenance: 1-1.5 mg/kg/day IV/IM divided q4-6hr; not to exceed 16 mg/day
Spinal Cord Compression
2 mg/kg/day IV divided q6hr
Contraindication
Systemic fungal infections . Hypersensitivity to any component of this product, including sulfites
Mode of Action
Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response.
Precaution
This product, like many other steroid formulations, is sensitive to heat. Therefore, it should not be autoclaved when it is desirable to sterilize the exterior of the vial. Following prolonged therapy, withdrawal of corticosteroids may result in symptoms of the corticosteroid withdrawal syndrome including fever, myalgia, arthralgia, and malaise. This may occur in patients even without evidence of adrenal insufficiency. There is an enhanced effect of corticosteroids in patients with hypothyroidism and in those with cirrhosis. Corticosteroids should be used cautiously in patients with ocular herpes simplex for fear of corneal perforation. The lowest possible dose of corticosteroid should be...
... Show moreSide Effect
Acne,Adrenal suppression,Arrhythmia,Bradycardia,Cardiac arrest,Cataracts,Change in spermatogenesis,Delayed wound healing,Depression,Diabetes mellitus,Diaphoresis,Emotional instability,Erythema,Euphoria,Exophthalmos,GI perforation,Glaucoma,Glucose intolerance,Glucosuria,Hepatomegaly,Hypokalemic alkalosis,Increased intracranial pressure,Increased transaminases,Insomnia,Kaposi's sarcoma,Menstrual irregularity,Moon face,Myopathy,Neuritis,Osteoporosis,Peptic ulcer,Perianal pruritus,Petechia,Perianal pruritus,Pituitary adrenal axis suppression,Pseudotumor cerebri (on withdrawal),Psychosis,Pulmonary edema,Rash,Seizure,Spermatogenesis altered (increased or decreased),Ulcerative esophagitis,Urticaria,Vertigo,Weight gain
Pregnancy Category Note
Pregnancy Corticosteroids readily cross the placenta Adverse developmental outcomes including orofacial clefts (cleft lip with or without cleft palate), intrauterine growth restriction, and decreased birth weight have been reported with maternal use of corticosteroids during pregnancy Pregnancy testing is recommended for females of reproductive potential before initiating treatment Contraception Use effective contraception during treatment and for at least 1 month following final dose Infertility in males Steroids may increase or decrease motility and number of spermatozoa in some patients In animals, dexamethasone affects male spermatogenesis Lactation Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous...
... Show moreInteraction
Increased risk of hypokalaemia when used concurrently with potassium-depleting drugs such as amphotericin B and loop diuretics. Reduces efficacy of isoniazid, salicylates, vaccines and toxoids. Increased activity of dexamethasone and cyclosporin when used together. Concurrent use with aspirin or ethanol may lead to increased GI side effects.
Potentially Fatal: Reduced efficacy in combination with ephedrine, cholestyramine, phenytoin, phenobarbital and rifampicin.
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