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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Metaloc.
CONSULT YOUR DOCTOR
Metaloc may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Metaloc is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
CONSULT YOUR DOCTOR
It is not known whether Metaloc alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Metaloc is safe to use in patients with kidney disease. No dose adjustment of Metaloc is recommended.
SAFE IF PRESCRIBED
Metaloc is safe to use in patients with liver disease. No dose adjustment of Metaloc is recommended.
Medicine Overview of Metaloc 50mg Tablet
Introduction
Metaloc belongs to a group of medicines called beta-blockers. It is used to treat high blood pressure (hypertension), angina (heart-related chest pain), irregular heart rhythms (arrhythmia). It also helps to prevent future heart attacks and stroke and to prevent migraine. Metaloc is also used to relieve the symptoms caused by an overactive thyroid gland. It may be prescribed alone or together with other medications. The dose and frequency depend on what you are taking it for and the severity of your condition. It may be taken empty stomach or with a meal, but take it regularly at the same time...
... Show moreUses of Metaloc
- Hypertension (high blood pressure)
- Angina (heart-related chest pain)
- Arrhythmia
Side effects of Metaloc
Common
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Slow heart rate
- Headache
- Dizziness
- Tiredness
- Stomach pain
- Nausea
- Breathlessness
How to use Metaloc
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metaloc is to be taken with food.
How Metaloc works
Metaloc is a short-acting beta blocker that works specifically on the heart. It works by slowing down the heart rate and makes the heart more efficient at pumping blood around the body.
Quick Tips
- It may cause dizziness. If this happens to you, get up slowly when rising from a sitting or lying position.
- It can hide symptoms of low blood sugar if you are diabetic. Monitor your blood sugar levels regularly.
- Do not stop taking Metaloc suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.
Brief Description
Indication
Heart failure, Migraine, Acute MI, Diabetic nephropathy, Hypertension, Cardiac arrhythmias, Angina pectoris
Administration
May be taken with or without food.
Adult Dose
Oral Hypertension Adult: Conventional tab: Initially, 100 mg/day in single or 2 divided doses, may increase wkly to 400 mg/day depending on response. Maintenance: 100-200 mg/day. Extended-release tab: Initially, 25-100 mg once daily. Angina pectoris Adult: Conventional tab: 50-100 mg bid or tid. Extended release tab: 100 mg once daily. Max: 200 mg once daily. Cardiac arrhythmias Adult: 50 mg bid or tid, may increase to 300 mg/day in divided doses if needed. Adjunct in hyperthyroidism Adult: 25-50 mg 4 times/day. Prophylaxis of migraine Adult: Conventional tab: 100-200 mg/day in divided doses. Extended release tab: 100 mg once daily. Stable...
... Show moreChild Dose
Oral
Hypertension
Conventional tab: 1-17 years: 1-2 mg/kg/day PO divided BID; not to exceed 6 mg/kg/day or ?200 mg/day
Extended-release tab: >6 years: 1 mg/kg PO qDay; not to exceed 50 mg/day initially;
adjusted on basis of patient response; not to exceed 2 mg/kg/day or <200 mg/day
Renal Dose
Renal impairment: No dosage adjustment needed.
Contraindication
2nd or 3rd degree AV block, sick sinus syndrome, hypotension, decompensated heart failure, sinus bradycardia, severe peripheral arterial circulatory disorders, cardiogenic shock, severe asthma and bronchospasm, untreated phaeochromocytoma, Prinzmetal's angina, metabolic acidosis.
Mode of Action
Metoprolol selectively inhibits beta1-adrenergic receptors but has little or no effect on beta2-receptors except in high doses. It does not exhibit membrane stabilising or intrinsic sympathomimetic activity.
Precaution
Patients w/ myasthenia gravis, well-compensated heart failure, bronchospastic disease, AV conduction disorders, substantial cardiomegaly. May mask signs and symptoms of hyperthyroidism and hypoglycaemia. Patients w/ history of cardiac failure or those w/ minimal cardiac reserve. Patients undergoing major surgery involving general anaesth. Avoid abrupt withdrawal as it may precipitate thyroid storm or MI, and may exacerbate angina and ventricular arrhythmias. Hepatic impairment. Pregnancy and lactation. Patient Counselling May affect ability to drive or operate machinery. Monitoring Parameters Monitor BP, ECG and heart rate. Lactation: Drug is concentrated in breast milk; use with caution (American Academy of Pediatrics states that drug...
... Show moreSide Effect
1-10%
Dizziness (10%),Headache (10%),Tiredness (10%),Depression (5%),Diarrhea (5%),.Pruritus (5%),Bradycardia (9%),Rash (5%),Dyspnea (1-3%),Cold extremities (1%),Constipation (1%),Dyspepsia (1%),Heart failure (1%),Hypotension (1%),Nausea (1%),Flatulence (1%),Heartburn (1%),Xerostomia (1%),Wheezing (1%),Bronchospasm (1%)
Frequency Not Defined
Decreased exercise tolerance,Raynaud phenomenon,Increased triglyceride levels and insulin resistance, decreased high-density lipoprotein (HDL) levels
Interaction
Additive effect w/ catecholamine-depleting drugs (e.g. reserpine) and MAOIs. May antagonise ?1-adrenergic stimulating effects of sympathomimetics. Additive negative effects on SA or AV nodal conduction w/ cardiac glycosides, nondihydropyridine Ca channel blockers. Paradoxical response to epinephrine may occur. Increased plasma concentrations w/ CYP2D6 inhibitors (e.g. bupropion, cimetidine). Increased risk of hypotension and heart failure w/ myocardial depressant general anaesth (e.g. diethyl ether). Risk of pulmonary HTN w/ vasodilators (e.g. hydralazine) in uraemic patients. Reduced plasma levels w/ rifampicin. May increase negative inotropic and negative dromotropic effect of antiarrhythmic drugs (e.g. quinidine, amiodarone). May reduce antihypertensive efficacy w/ indometacin. May increase...
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