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Angimil
Medimet Pharmaceuticals Ltd.
Generic: Verapamil Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Angimil.
CONSULT YOUR DOCTOR
Angimil may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Angimil is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Angimil may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Angimil should be used with caution in patients with kidney disease. Dose adjustment of Angimil may be needed. Please consult your doctor.
Careful monitoring of the patient for any signs of overdosage is advisable.
CAUTION
Angimil should be used with caution in patients with liver disease. Dose adjustment of Angimil may be needed. Please consult your doctor.
Medicine Overview of Angimil 80mg Tablet
Introduction
Angimil is used to treat angina (heart-related chest pain), high blood pressure and some types of irregular heartbeats (arrhythmia). It works by relaxing blood vessels to lower blood pressure. This helps to reduce the workload of the heart. Angimil may be taken with or without food, but it is better to take it regularly at a fixed time each day as advised by your doctor. Keep using this medicine even if you feel well. If you stop taking it suddenly, your condition may worsen. This medicine is only part of a treatment program that should include a healthy diet, regular...
... Show moreUses of Angimil
- Hypertension (high blood pressure)
- Angina (heart-related chest pain)
- Arrhythmia
Side effects of Angimil
Common
- Headache
- Constipation
- Infection
- Dizziness
- Sinus infection
- Flu-like symptoms
- Peripheral edema
How to use Angimil
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Angimil is to be taken with food.
How Angimil works
Angimil is a calcium channel blocker. It blocks the action of calcium on the heart and blood vessels, thereby widening the blood vessels and allowing more blood and oxygen to reach the heart. This reduces blood pressure and decreases the chances of angina (chest pain).
Quick Tips
- It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- It may cause you to feel lightheaded or weak especially when you stand up (orthostatic hypotension). Rise slowly if you have been sitting or lying down.
- It is best to avoid drinking alcohol while taking Angimil as it may make the side effects worse.
Brief Description
Indication
Essential hypertension, Angina pectoris, and prevention of re-infarction, Supraventricular arrhythmias, Paroxysmal supraventricular tachycardias, Atrial fibrillation, with rapid ventricular response (except WPWS), Atrial flutter with rapid conduction, Extrasystoles, Acute hypertension, Acute coronary insufficiency, For the prophylaxis and / or therapy of ectopic arrhythmias (predominantly ventricular extrasystoles) in halothane anaesthesia and in the application of adrenaline in halothane anaesthesia respectively.
Administration
Should be taken with food.
Adult Dose
Oral Hypertension Adult: Immediate release 80 mg PO q8hr initially; maintenance: 80-320 mg PO q12hr Extended release 180 mg/day PO (120 mg/day initially if patient elderly or of small stature); for desired response, may be increased to 240 mg/day PO, then by 120 mg/day at weekly intervals; not to exceed 480 mg/day Angina Immediate release 80 mg PO q8hr initially; usual range: 80-120 mg PO q8hr; not to exceed 480 mg/day Extended release 180 mg/day PO at bedtime initially; maintenance: 180-480 mg/day PO at bedtime Chronic Atrial Fibrillation & Paroxysmal Supraventricular Tachycardia Treatment of chronic atrial fibrillation (rate control); prevention...
... Show moreChild Dose
Supraventricular Tachycardia
1-15 years old: 0.1-0.3 mg/kg (not to exceed 5 mg) IV over 2 minutes; second dose (not to exceed 10 mg) may be given after 30 minutes
Alternatively (not well established), 4-8 mg/kg/day PO divided q8hr
Renal Dose
Renal impairment: Use with caution; monitor ECG; for Verelan PM, manufacturer recommends 100 mg at bedtime initially; if CrCl <10 mL/min, reduce dose by 25-50%
Contraindication
Cardiogenic shock, hypotension (systolic pressure <90 mmHg), marked bradycardia, uncompensated heart failure, 2nd- or 3rd-degree AV block (unless pacemaker is fitted), sick-sinus syndrome, severe ventricular dysfunction, atrial flutter or atrial fibrillation and accessory bypass tract (e.g. Wolff-Parkinson-White, Lown-Ganong-Levine syndromes).
Mode of Action
Verapamil inhibits entry of calcium ions into arterial smooth muscle cells as well as the myocytes and conducting tissue. These actions lead to reversal and preventions of coronary artery spasm, reduction in afterload through peripheral vasodilatation and reduction in ventricular rate in patients with chronic atrial flutter or fibrillation and reduction in the occurrence of paroxysmal supraventricular tachycardia. Verapamil reduces BP, relieves angina and slows AV conduction.
Precaution
Patient w/ bradycardia or 1st-degree AV block, attenuated neuromuscular transmission, hypertrophic cardiomyopathy. Avoid abrupt withdrawal. Renal and hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor BP, heart rate, ECG, LFTs (periodically).
Lactation: Distributed in milk; nursing infant doses range from <0.01% to 0.1% of mother’s dose; manufacturer suggests refraining from nursing (though American Academy of Pediatrics committee states that drug is compatible with nursing)
Side Effect
>10%
Headache,Gingival hyperplasia
1-10%
Constipation (9%),Dizziness (4%),Hypotension (4%),Dyspepsia (3%),Nausea (3%),Edema (2%),Rash (2%),Increased liver enzymes (1%),Sleep disturbance (1%),Dyspnea
Interaction
Increased cardiac depressant effects with beta-blockers and flecainide. Increased risk of additive bradycardia, conduction disturbances and digoxin toxicity with digoxin. Increased risk of bradycardia and hypotension with remifentanil and sufentanil. Increased levels of both everolimus and verapamil on concurrent use. May increase doxorubicin, buspirone, carbamazepine, ciclosporin, epirubicin, eplerenone, quinidine, statins, sirolimus, tacrolimus, quinupristin/dalfopristin levels. Verapamil increase blood alcohol levels. Unpredictable interactions with lithium. Decreased verapamil concentrations with phenobarbital, sulfinpyrazone, rifampicin, rifabutin and rifapentine. Increased verapamil concentrations with protease inhibitors and cimetidine. Potentially Fatal: Increased cardiac depressant effects with amiodarone. Increased risk of QT prolongation with dofetilide, ranolazine, sertindole. Additive bradycardia...
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