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Metolaz 0.5
Navana Pharmaceuticals Ltd.
Generic: Metolazone
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Metolaz 0.5.
SAFE IF PRESCRIBED
Metolaz 0.5 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Metolaz 0.5 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Metolaz 0.5 may cause side effects which could affect your ability to drive.
As Metolaz 0.5 may cause drowsiness, dizziness, blurred vision, or lightheadedness and this may affect your ability to drive.
SAFE IF PRESCRIBED
Metolaz 0.5 is safe to use in patients with kidney disease. No dose adjustment of Metolaz 0.5 is recommended.
CONSULT YOUR DOCTOR
There is limited information available on the use of Metolaz 0.5 in patients with liver disease. Please consult your doctor.
Medicine Overview of Metolaz 0.5 500mcg Tablet
Introduction
Metolaz 0.5 is a type of diuretic (water pill) medicine. This medicine reduces excess fluid levels in the body and is used to treat edema (fluid overload) associated with heart, liver, kidney, or lung disease. It is also used in treatment of hypertension (high blood pressure). Metolaz 0.5 makes you lose excess water through urine. It may be used alone or in combination with other medicines. This medicine should be taken only during day time to avoid frequent urination at night. You must take this medicine in the dose and duration as advised by the doctor and never stop it...
... Show moreUses of Metolaz 0.5
- Hypertension (high blood pressure)
Side effects of Metolaz 0.5
Common
- Headache
- Nausea
- Increased blood uric acid
- Decreased potassium level in blood
- Glucose intolerance
- Altered blood lipid level
How to use Metolaz 0.5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metolaz 0.5 is to be taken with food.
How Metolaz 0.5 works
Metolaz 0.5 is a thiazide diuretic. It lowers blood pressure and fluid retention in edema by removing the extra water and certain electrolytes from the body. Over time it also works by relaxing blood vessels and improving blood flow.
What if you forget to take Metolaz 0.5?
If you miss a dose of Metolaz 0.5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take it in the morning with breakfast to avoid getting up at night to urinate.
- It makes you feel dizzy. Avoid driving and attention requiring activity until you know how it affects you.
- Avoid alcohol intake while taking Metolaz 0.5 as it may increase the dizziness.
- It may cause a sudden drop of sodium level in blood. Avoid low sodium diet while you are taking this medication.
- Monitor your blood pressure after starting Metolaz 0.5, and notify your doctor if it does not lower down.
- Notify your doctor if you experience dizziness, tiredness, or muscle weakness that does not go away.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Oedema, Hypertension
Administration
Should be taken with food. Take after breakfast.
Adult Dose
Oral
Hypertension
Adult: Initially, 1.25 mg daily, adjusted after 3-4 wk according to response. Usual dose: 2.5-5 mg daily, either alone or with other antihypertensives.
Maintenance dose: 5 mg on alternate days.
Formulations with enhanced bioavailability: 0.5-1 mg daily.
Oedema
Adult: 5-10 mg daily, increased if necessary to 20 mg daily. Max: 80 mg in 24 hr.
Elderly: Initially, 2.5 mg/day or every other day.
Child Dose
Oedema
0.2-0.4 mg/kg/day PO in single daily dose or divided q12hr
Renal Dose
Renal impairment: Not necessary to supplement dose in hemodialysis or peritoneal dialysis
Contraindication
Anuria; hepatic coma or pre-coma. Pregnancy.
Mode of Action
Metolazone is a thiazide-like diuretic. It inhibits reabsorption of sodium in the distal tubules resulting in increased excretion of sodium and water, as well as potassium and hydrogen ions.
Precaution
Pre-diabetes or DM; gout; SLE; hepatic and renal impairment; hypercholesterolaemia. Correct electrolyte disturbances prior to therapy. Risk of cross-sensitivity with sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, thiazides and loop diuretics.
Lactation: Not recommended
Side Effect
Chest pain, palpitation, necrotising angiitis, orthostatic hypotension, syncope, venous thrombosis, vertigo, volume depletion; depression, dizziness, chills, drowsiness, fatigue, restlessness, headache, lightheadedness; petechiae, photosensitivity, hypersensitivity reactions; gout attacks, electrolyte disturbances; abdominal bloating, diarrhoea, abdominal pain, anorexia, constipation, epigastric distress, nausea, xerostomia, pancreatitis, vomiting; impotence; aplastic anaemia, thrombocytopenia, haemoconcentration, leukopenia; cholestatic jaundice, hepatitis; joint pain, muscle cramps, weakness, neuropathy, paraesthesia; blurred vision; increased BUN, glucosuria.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.
Interaction
Hypotensive and nephrotoxic effects of ACE inhibitors may be enhanced. Absorption may be reduced with bile acid sequestrants. Hyperglycaemic effect may be enhanced with diazoxide. May increase serum concentration and QTc-prolonging effect of dofetilide. May reduce lithium excretion. Hypotensive effect may be increased with alcohol.
Potentially Fatal: Increased risk of nephrotoxicity with ciclosporin. Severe electrolyte disturbances may occur with furosemide.
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