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Milran 50
Beacon Pharmaceuticals PLC
Generic: Milnacipran Hydrochloride
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Milran 50. Please consult your doctor.
CONSULT YOUR DOCTOR
Milran 50 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Milran 50 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Milran 50 may cause side effects which could affect your ability to drive.
As Milran 50 may impair your thinking or reactions and this may affect your ability to drive.
CAUTION
Milran 50 should be used with caution in patients with kidney disease. Dose adjustment of Milran 50 may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Milran 50 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Milran 50 may not be needed in these patients. Please consult your doctor.
Caution is advised in patients with the severe liver disease.
Medicine Overview of Milran 50mg Tablet
Introduction
Milran 50 is a prescription medicine used in the treatment of fibromyalgia (a condition in which there are generalized pain and tenderness in the body) and depression. It works by increasing the level of chemical messengers (serotonin and noradrenaline), helping in faster recovery. Milran 50 may be taken with or without food. It is advised to take this medicine at a fixed time each day to maintain a consistent level in the blood. If you miss any doses, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you...
... Show moreUses of Milran 50
- Fibromyalgia
- Depression
Side effects of Milran 50
Common
- Nausea
- Vomiting
- Dizziness
- Insomnia (difficulty in sleeping)
- Constipation
- Anxiety
- Decreased appetite
- Increased sweating
- Sexual dysfunction
How to use Milran 50
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Milran 50 may be taken with or without food, but it is better to take it at a fixed time.
How Milran 50 works
Milran 50 works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
What if you forget to take Milran 50?
If you miss a dose of Milran 50, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Milran 50 helps in treating depression and anxiety.
- It may also be used to treat nerve pain from diabetes and some other forms of chronic pain.
- It may take 2 to 4 weeks for Milran 50 to start working. Keep taking it as prescribed.
- It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Milran 50 as it may cause excessive drowsiness and increase the risk of liver damage.
- It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Depression, Fibromyalgia
Administration
Should be taken with food. Preferably taken during meals.
Adult Dose
Oral
Fibromyalgia
Adult:
Day 1: 12.5 mg once
Days 2-3: 25 mg/day (12.5 mg twice daily)
Days 4-7: 50 mg/day (25 mg twice daily)
After Day 7: 100 mg/day (50 mg twice daily)
Based on individual patient response, the dose may be increased to 200 mg/day (100 mg twice daily).
Depression
Adult: 50 mg bid.
Hepatic impairment
Mild or moderate (Child-Pugh A or B): No dosage adjustment required
Severe (Child-Pugh C): Caution advised
Child Dose
<17 years: Safety and efficacy not established
Renal Dose
Renal impairment
Mild (CrCl 50-80 mL/min): No dosage adjustment required
Moderate (CrCl 30-49 mL/min): Use with caution
Severe (CrCl 5-29 mL/min): Reduce maintenance dosage by 50% (ie, to 50 mg/day divided q12hr)
End-stage renal disease (ESRD): Use not recommended
Contraindication
Uncontrolled narrow-angle glaucoma. Concomitant use w/ MAOI or w/in 2 wk after withdrawal of MAOI.
Mode of Action
SNRI; has no affinity for other neurotransmitter receptors (including gamma-aminobutyric acid [GABA], beta-adrenergic, opiate, histaminergic, and benzodiazepine receptors) and has no MAOI activity.
Precaution
Patient w/ major depressive disorder or other psychiatric disorders, history of dysuria, controlled narrow-angle glaucoma, pre-existing HTN, tachyarrhythmias or other CV disease, history of seizure disorder or condition predisposing to seizures (e.g. brain damage, alcoholism). Avoid abrupt withdrawal. Severe hepatic and moderate to severe renal impairment including ESRD. Pregnancy and lactation.
Lactation: Drug is excreted in human milk; peak breast milk concentration is observed within 4 hours after maternal dose, and estimated infant exposure is 5% of maternal dose; limited data are available regarding infant exposure, but caution is advised
Side Effect
>10%
Nausea (37%),Headache (18%),Constipation (16%),Hot flush (12%),Insomnia (12%)
1-10% (selected)
Dizziness,Hyperhidrosis,Hypertension,Migraine,Palpitations,Tachycardia,Vomiting,Xerostomia
Frequency Not Defined
Abnormal bleeding,Depression (worsening),Serotonin syndrome,Suicidal thoughts,Withdrawal signs or symptoms
Potentially Fatal: Serotonin syndrome or neuroleptic malignant syndrome (NMS)-like reactions, suicidal thinking/behaviour.
Interaction
Increased risk of bleeding w/ aspirin, NSAIDs, warfarin and other drugs that affect coagulation. Increased CNS effects w/ centrally-acting drugs (e.g. clomipramine). Increased risk of serotonin syndrome and NMS-like reactions w/ serotonergic drugs (e.g. tramadol), SSRIs, other selective serotonin-norepinephrine reuptake inhibitors, 5-HT1 receptor agonists (e.g. sumatriptan), antipsychotic agents and other dopamine antagonists. May inhibit antihypertensive effect of clonidine. May potentiate adverse haemodynamic effects w/ digoxin. Paroxysmal HTN and cardiac arrhythmia may occur when taken concurrently w/ epinephrine or norepinephrine.
Potentially Fatal: Increased risk of serotonin syndrome and NMS-like reactions w/ MAOIs (e.g. linezolid, IV methylene blue).
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