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Misopil
General Pharmaceuticals Ltd.
Generic: Misoprostol
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Misopil. Please consult your doctor.
UNSAFE
Misopil is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CAUTION
Misopil should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
UNSAFE
Misopil may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Misopil is safe to use in patients with kidney disease. No dose adjustment of Misopil is recommended.
However, inform your doctor if you have an underlying kidney disease. This medicine may be started with a low dose and then increased with caution by your doctor.
SAFE IF PRESCRIBED
Misopil is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Misopil may not be needed in these patients. Please consult your doctor.
Medicine Overview of Misopil 200mcg Tablet
Introduction
Misopil is a medicine used for medical abortion (terminating a pregnancy). It is also used for preventing excessive bleeding after delivery. This medicine acts on the uterus and increases its contraction. Misopil is given alone or in combination with some other medicine to attain the maximum benefit. It should be taken with food or as your doctor's advice. It should be taken orally, by swallow the tablets whole with a drink of water. If you experience vomiting within 30 minutes of tablet intake, inform your doctor or take another tablet. The medicine may take 24 hours to show its action...
... Show moreUses of Misopil
- Medical abortion
- Post-delivery bleeding
Side effects of Misopil
Common
- Menorrhagia (heavy menstrual bleeding)
- Vomiting
- Nausea
- Uterine contractions
- Diarrhea
- Stomach cramp
How to use Misopil
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Misopil is to be taken with food.
How Misopil works
Misopil increases contractions of the uterus to cause abortion. It can also prevent post-delivery bleeding due to poor contraction of the uterus.
What if you forget to take Misopil?
If you miss a dose of Misopil, it is likely that the termination will not be fully effective. Talk to your doctor if you forget to take Misopil.
Quick Tips
- Misopil helps terminate pregnancy when used along with another medicine called mifepristone.
- It may also be used to prevent excessive bleeding after delivery.
- For pregnancy termination:
- Use caution while driving or doing anything that requires concentration as it can cause dizziness and sleepiness.
- It does not affect fertility. Use contraception to avoid pregnancy.
Brief Description
Indication
NSAID-induced ulcers, Termination of pregnancy, Benign gastric and duodenal ulcers
Administration
Should be taken with food.
Adult Dose
NSAID-Induced Ulcer Adult: Benign gastric and duodenal ulceration and NSAID associated ulceration: 800 mcg daily (in 2-4 divided doses) with breakfast or main meals and at bedtime; treatment should be continued for at least 4 weeks and may be continued for up to 8 weeks if required. Prophylaxis of NSAID induced gastric and duodenal ulcer: 200 mcg 2-4 times daily taken with NSAID. If this dose cannot be tolerated, a dose of 100 mcg can be used. Misoprostol should be taken for the duration of NSAID therapy Induction of labor: 100 mcg taken orally. If cervical ripening or active labor...
... Show moreRenal Dose
Renal impairment: Use with caution; peak plasma concentration, half-life, and bioavailability may be increased, but it is not clear whether these increases are of clinical relevance
Contraindication
Misoprostol is contraindicated to anyone with a history of allergy to prostaglandins. Women of childbearing potential. Pregnancy and lactation.
Mode of Action
Misoprostol, a synthetic prostaglandin E1 analogue, exerts its antisecretory activity by directly acting on specific prostaglandin receptors found on the surface of gastric parietal cells. It exerts its protective effects on the mucosa by replacing the prostaglandins consumed during prostaglandin-inhibiting therapies e.g. NSAIDs.
Precaution
In case of prevention and treatment of NSAID induced gastric and duodenal ulcer: Misoprostol is contraindicated in women who are pregnant, and should not be used in women of child bearing potential unless the patient requires NSAID therapy. Women of child bearing potential should be told that they must not be pregnant when Misoprostol therapy is initiated and they must use an effective contraception method while taking misoprostol. Conditions where hypotension might precipitate severe complications e.g. cerebrovascular or CV disease. Inflammatory bowel disease. Patients prone to dehydration. Elderly. Renal impairment. Lactation: Drug is rapidly metabolized in mother to misoprostol acid,...
... Show moreSide Effect
>10%
Diarrhea (14-40%),Abdominal pain (13-20%)
1-10%
Headache (2%)
Frequency Not Defined
Anaphylaxis,Anemia,Cardiac dysrhythmia,Chest pain,Flatulence,Gastrointestinal hemorrhage,Hearing loss,Myocardial infarction,Nausea
Rupture of uterus,Thromboembolic disorder
Interaction
May increase effects of oxytocin. Increased risk of misoprostol-induced diarrhoea with magnesium-containing antacids.
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