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Safety Advices
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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Myleran. Please consult your doctor.
CONSULT YOUR DOCTOR
Myleran is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Myleran is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
CONSULT YOUR DOCTOR
It is not known whether Myleran alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Myleran is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Myleran may not be needed in these patients. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Myleran in patients with liver disease. Please consult your doctor.
Medicine Overview of Myleran 2mg Tablet
Introduction
Myleran is used in the treatment of some cancers of blood like chronic myeloid leukaemia. It is used in combination with other cancer medicines during hematopoietic progenitor cell transplantation (HPCT). It may also be used to treat some other types of cancer. Myleran can be taken with or without food, but better to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as...
... Show moreUses of Myleran
- Blood cancer (Chronic myeloid leukaemia)
Side effects of Myleran
Common
- Decreased blood cells (red cells, white cells, and platelets)
- Abdominal pain
- Anxiety
- Nausea
- Vomiting
- Loss of appetite
- Decreased magnesium level in blood
- Decreased potassium level in blood
- Diarrhea
- Fever
- Headache
- Increased glucose level in blood
- Insomnia (difficulty in sleeping)
- Stomatitis (Inflammation of the mouth)
How to use Myleran
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Myleran may be taken with or without food, but it is better to take it at a fixed time.
How Myleran works
Myleran is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
What if you forget to take Myleran?
If you miss a dose of Myleran, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Seek immediate medical attention if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches) as busulfan can lower the ability of your blood to clot and body to fight infections.
- Inform your doctor if you have thalassemia (abnormal hemoglobin in blood), gout (arthritis due to impaired metabolism of uric acid) or if you have had radiotherapy.
- Do not receive live vaccine while using busulfan, and avoid contact with individuals who have recently received the same.
- Tell your doctor if you are or planning to become pregnant or are breastfeeding.
- Common Side Effects.
Brief Description
Indication
Chronic myeloid leukaemia, Bone marrow transplantation, Polycythemia vera, Essential thrombocythemia,
Administration
May be taken with or without food. Take w/ chilled liqd, ensure adequate fluid intake.
Adult Dose
Oral
Palliative treatment of chronic myeloid leukemia
Adult: 60 mcg/kg daily. Maintenance: 0.5-2 mg daily. Max: 4 mg daily.
Polycythemia vera
Adult: 4-6 mg daily continued for 4-6 wk with blood counts monitoring.
Essential thrombocythemia
Adult: 2-4 mg daily.
Conditioning regimens for bone marrow transplantation
Adult: 3.5-4 mg/kg daily in divided doses for 4 days up to a total dose of 14-16 mg/kg. Usually used with cyclophosphamide for ablation of recipient's bone marrow.
Contraindication
Pregnancy and lactation. Hypersensitivity.
Mode of Action
Busulfan reacts with N-7 position of guanosine and interferes with DNA replication and RNA transcription by alkylating and cross-linking the DNA strands.
Precaution
Prior treatment with other myelosuppressive drugs, patients predisposed to seizures. May cause secondary malignancies (tumors, acute leukaemias, ovarian failure). Previous irradiation/therapy. Monitor blood counts carefully during therapy. Discontinue if lung toxicity develops.
Side Effect
GI symptoms, anorexia, wt loss, weakness, hyperpigmentation, amenorrhoea, cataracts, cough or hoarseness, impaired fertility and gonadal function, dry skin, liver damage, gynaecomastia.
Potentially Fatal: Bone marrow depression manifesting as thrombocytopaenia, leucopaenia, anaemia. Interstitial pulmonary fibrosis (known as "busulfan lung" on prolonged treatment).
Interaction
Decreased clearance when used with cyclophosphamide and itraconazole. Increased clearance by phenytoin. May reduce response to vaccines, possibility of generalized infections with live vaccines. Combination with thioguanine results in oesophageal varices and abdominal liver function tests.
Potentially Fatal: Cytotoxic agents may increase risk of pulmonary toxicity.
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.