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Skin fungal infections, treatment of interdigital tinea pedis, tinea cruris, and tinea corporis
Administration
Apply a thin layer to the affected areas plus half inch margin of healthy surrounding skin
Adult Dose
Topical/Cutaneous
Skin fungal infections
Adult: As hydrochloride: Apply sufficient amount of cream once daily or gel bid, morning and evening.
Treatment duration: Tinea cruris and tinea corporis: 2-4 wk; tinea pedis: 4-6 wk; severe infections: May require prolonged treatment.
Contraindication
Hypersensitivity.
Mode of Action
Naftifine is a synthetic allylamine antifungal that selectively inhibits the enzyme squalene monooxygenase resulting in reduced synthesis of the primary sterol, ergosterol, within the fungal membrane. It appears to have both fungicidal and fungistatic activity.
Precaution
Avoid contact with eyes, nose, mouth and other mucous membranes. Avoid use of occlusive dressings or wrappings. Discontinue use if irritation occurs. Pregnancy and lactation.
Side Effect
Burning, stinging, dryness, redness, pruritus, local irritation, rash, skin tenderness.
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