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Nalphin
The ACME Laboratories Ltd.
Generic: Nalbuphine Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Nalphin.
SAFE IF PRESCRIBED
Nalphin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Nalphin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Nalphin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Nalphin should be used with caution in patients with kidney disease. Dose adjustment of Nalphin may be needed. Please consult your doctor.
CAUTION
Nalphin should be used with caution in patients with liver disease. Dose adjustment of Nalphin may be needed. Please consult your doctor.
Medicine Overview of Nalphin 20mg/2ml Injection
Introduction
Nalphin is a pain relieving medicine. It is used to treat moderate to severe pain. It is also used as a premedication before surgery. This medicine is generally used when alternative medicines are ineffective or inadequate. Nalphin is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), nausea, vomiting, sweating a lot, and tiredness. If any of...
... Show moreUses of Nalphin
- Moderate to severe pain
Side effects of Nalphin
Common
- Headache
- Dizziness
- Sleepiness
- Vomiting
- Nausea
- Constipation
How to use Nalphin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Nalphin works
Nalphin is an opioid analgesic (pain reliever) which works by blocking transmission of pain signals to the brain to lower pain perception.
What if you forget to take Nalphin?
If you miss a dose of Nalphin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Use Nalphin as instructed by your doctor. Never take in greater amounts or more often than prescribed.
- It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
- Avoid consuming alcohol when taking the Nalphin, as it may cause excessive sleepiness or drowsiness.
- Inform your doctor if you have ever been diagnosed with kidney or liver problems.
- Store opioid pain relievers in a safe place and out of reach of others.
Brief Description
Indication
Moderate to severe pain, Pain associated with MI, Balanced anaesthesia
Administration
IV Administration Administer each 10 mg by IV push over 3-5 minutes
Adult Dose
Parenteral Moderate to severe pain Adult: IM/IV/SC: 10-20 mg 3-6 hrly as required. Non-opioid-tolerant patients: Max single dose: 20 mg. Max daily dose: 160 mg. Intravenous Adjunct in balanced anaesthesia Adult: Induction: 0.3-3 mg/kg over 10-15 min. Maintenance: 0.25-0.5 mg/kg as single admin if required. Hepatic impairment: Caution; dose reduction may be necessary; monitor
Child Dose
Pain <1 year: Safety and efficacy not established >1 year: 0.1-0.2 mg/kg IV/IM/SC q3-4hr PRN; individual dose not to exceed 20 mg; not to exceed 160 mg/day
Renal Dose
Renal impairment: Caution; dose reduction may be necessary; monitor
Contraindication
Hypersensitivity. Absolute: Diarrhea associated with toxins, pseudomembranous colitis, respiratory depression (<12 beats/min) Acute asthma, bradycardia, inflammatory bowel disease, respiratory impairment
Mode of Action
Nalbuphine is a phenanthrene derivative opioid analgesic with mixed opioid agonist and antagonist activity. It inhibits the ascending pain pathways, altering the perception of and response to pain by binding to opiate receptors in the CNS. It also produces generalised CNS depression.
Precaution
May impair ability to drive or operate machinery. Emotionally unstable patients or patients with history of opiate abuse; closely monitor these patients during long-term therapy. Impaired respiration due to other drugs, uraemia, bronchial asthma, severe infection, cyanosis, respiratory obstruction. MI patients who exhibit nausea and vomiting and in those about to undergo biliary tract surgery. Head injury, intracranial lesions or pre-existing increased intracranial pressure. Renal or hepatic impairment. Elderly and debilitated patients. Pregnancy and lactation.
Lactation: Insignificant amount distributed in milk; use with caution
Side Effect
>10%
Sedation (36%)
1-10%
Clamminess (9%),Nausea and vomiting (6%),Dizziness (5%),Xerostomia (4%),Headache (3%)
<1%
Asthma,Bradycardia,Burning,Dyspnea,Hypertension,Hypotension,Itching,Miosis,Pulmonary edema,Respiratory depression,Tachycardia,Urticaria,Vertigo
Potentially Fatal: Anaphylactic or anaphylactoid and other serious hypersensitivity reactions e.g. shock, respiratory distress, respiratory arrest, bradycardia, cardiac arrest, hypotension, laryngeal oedema.
Pregnancy Category Note
Pregnancy category: B; D if used for prolonged periods or near term
Interaction
Additive CNS depressant effects may occur with other CNS depressants e.g. alcohol, anaesthetics, anxiolytics, hypnotics, TCAs and antipsychotics.
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