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Nerkein
Beximco Pharmaceuticals Ltd.
Generic: Bupivacaine
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Nerkein. Please consult your doctor.
CONSULT YOUR DOCTOR
Nerkein may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Nerkein is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Nerkein may cause side effects which could affect your ability to drive.
Nerkein may cause numbness to certain areas of the body for about 2-4 hours after having it. You should wait for the effect to wear off as this may affect your ability to drive
CAUTION
Nerkein should be used with caution in patients with kidney disease. Dose adjustment of Nerkein may be needed. Please consult your doctor.
CAUTION
Nerkein should be used with caution in patients with liver disease. Dose adjustment of Nerkein may be needed. Please consult your doctor.
Medicine Overview of Nerkein 5mg/ml Injection
Introduction
Nerkein is a prescription medication used as a local anesthetic. It is used during minor surgical procedures such as dental, oral, diagnostic, or other therapeutic procedures to anesthetize or numb the surgical area. This medicine can also be useful in the relief of pain, e.g. during labor. Nerkein blocks the nerve impulses that send pain signals to your brain and helps to perform a painless procedure by temporarily numbing the surgical area. Like many other medicines, this medicine also has few side effects. The most common side effects of this medicine are nausea, tingling sensation, slow heart rate, high blood...
... Show moreUses of Nerkein
- Local anesthesia (Numb tissues in a specific area)
Side effects of Nerkein
Common
- Nausea
- Paresthesia (tingling or pricking sensation)
- Slow heart rate
- Decreased blood pressure
- Dizziness
- Urinary retention
- High blood pressure
- Vomiting
How to use Nerkein
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Nerkein works
Nerkein is a local anesthetic. It works by blocking the transmission of pain signals from the nerves to the brain. This helps to decrease the sensation of pain.
What if you forget to take Nerkein?
If you miss a dose of Nerkein, please consult your doctor.
Quick Tips
- Nerkein is given as an injection by the healthcare professional.
- It may affect your concentration or make you feel sleepy, so avoid driving or using tools or machines until the next day.
- Consult your doctor immediately if you experience dizziness, lightheadedness, problem with sight or hearing or numbness around lips, tongue and mouth.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Local anesthesia, Epidural, Intrathecal anesthesia, Epidural analgesia
Adult Dose
Adult: Inj Percutaneous infiltration anesth For prolonged action: 9 mg w/ adrenaline (1 in 200,000), may repeat 2-10 mins later if needed. Max: 90 mg per dental sitting. Surgical anaesthesia Peripheral nerve block 12.5 mg (as 0.25% soln) or 25 mg (as 0.5% soln) . Max: 150 mg/dose. Sympathetic nerve block As 0.25% soln: 50-125 mg. Retrobulbar block As 0.75% soln: 15-30 mg. Caudal block In surgery: 37.5-75 mg (as 0.25% soln) or 75-150 mg (as 0.5% soln). Lumbar epidural block In surgery: 25-50 mg (as 0.25% soln) and 50-100 mg (as 0.5% soln). Spinal block: 0.5% soln: 10-20 mg...
... Show moreChild Dose
12 years
Local Anesthesia: Infiltration 0.25% infiltrated locally: 175 mg maximum
Caudal Block: 15-30 mL of 0.25% or 0.5% (preservative free)
Epidural Block Other Than Caudal Block: 10-20 mL of 0.25% or 0.5%; administer in 3-5 mL increments allowing sufficient time to detect toxic manifestations of inadvertent IV or IT administration (preservative free); for surgical procedures requiring high degree of muscle relaxation and prolonged effects administer10-20 mL of 0.75%; not to be used in obstetrical cases
Peripheral or Sympathetic Nerve Block
>12 years
Peripheral Nerve Block: 5 mL of 0.25-0.5%; 400 mg/day maximum
Sympathetic Nerve Block: 20-50 mL of 0.25%
Contraindication
Hypersensitivity to local anaesthetics of amide type. IV regional anaesthesia; paracervical block in obstetrics; spinal anaesthesia <18 yr. Lactation. Solutions containing preservatives for caudal or epidural block.
Mode of Action
Bupivacaine blocks both the initiation and conduction of nerve impulses reducing the permeability of neuronal membranes to Na ions resulting in inhibition of depolarization w/ resultant blockade of conduction.
Precaution
Hepatic disease; CV disease; children <12 yr; pregnancy. Elderly and debilitated patients.
Lactation: excretion in milk unknown/not recommended
Side Effect
CNS excitation may be followed by depression. Hypotension, bradycardia, arrhythmias and cardiac arrest; methaemoglobinaemia; seizures, restlessness, dizziness. Hypersensitivity. Prolonged block, Edema, Headache, Hypotension, Hypoventilation, Nausea, Nervousness, Palpitation, Respiratory arrest, Tachycardia, Tinnitus, Tremors, Vomiting
Potentially Fatal: Cardiac and sudden respiratory arrest.
Pregnancy Category Note
Pregnancy Category: C
Lactation: excretion in milk unknown/not recommended
Interaction
Additive systemic toxic effect w/ other local anaesth or agents structurally related to amide-type local anaesth (e.g. lidocaine and mexiletine). Increased risk of myocardial depression w/ antiarrhythmics. Enhanced adverse effects w/ hyaluronidase. Decreased clearance resulting to increased plasma concentrations w/ cimetidine and ranitidine. Increased risk of adverse effects w/ beta-blockers and Ca channel blockers.
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