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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Nifedipine. Please consult your doctor.
CONSULT YOUR DOCTOR
Nifedipine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Nifedipine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CAUTION
Nifedipine may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
Nifedipine may make you feel dizzy, faint, extremely tired or have visual disturbances. This may affect your ability to drive.
SAFE IF PRESCRIBED
Nifedipine is safe to use in patients with kidney disease. No dose adjustment of Nifedipine is recommended.
However, talk to your doctor if you have any underlying kidney disease.
CAUTION
Nifedipine should be used with caution in patients with liver disease. Dose adjustment of Nifedipine may be needed. Please consult your doctor.
Medicine Overview of Nifedipine 10mg Tablet
Introduction
Nifedipine is a medicine used to treat high blood pressure (hypertension) and to prevent angina (heart-related chest pain). It belongs to a class of medicines known as calcium channel blockers. It lowers blood pressure and reduces the workload of the heart. This helps prevent heart attacks and strokes. Nifedipine may be prescribed alone or along with other medicines. The dose and how often you need it will be decided by your doctor so that you get the right amount to treat your condition. Your doctor may adjust the dose depending on how you respond to this medicine and your blood...
... Show moreUses of Nifedipine
- Hypertension (high blood pressure)
- Angina (heart-related chest pain)
Side effects of Nifedipine
Common
- Ankle swelling
- Dizziness
- Edema (swelling)
- Fatigue
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Headache
- Palpitations
How to use Nifedipine
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nifedipine may be taken with or without food, but it is better to take it at a fixed time.
How Nifedipine works
Nifedipine is a calcium channel blocker. In high blood pressure, it normalizes the blood pressure by relaxing the blood vessels to reduce the pressure on them, thereby improving the blood flow in the body. The enhanced blood flow in the body further relaxes the heart muscles by reducing the workload on the heart. It also improves the oxygen flow in the body, thereby, preventing any heart-related chest pain.
What if you forget to take Nifedipine?
If you miss a dose of Nifedipine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take it at the same time every day to help you remember to take it.
- A sudden drop in your blood pressure may occur, especially when you first start taking Nicardia Retard 20 Tablet SR. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- It can cause ankle or foot swelling. To reduce the swelling, raise your legs while you are sitting down. Talk to your doctor if it does not go away.
- It may cause dizziness. Do not drive or perform any activity that requires mental focus until you know how Nicardia Retard 20 Tablet SR affects you.
- Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding.
Brief Description
Indication
Hypertension, Angina pectoris, Raynaud's syndrome, Stroke prevention
Administration
Immediate-release: May be taken with or without food. Avoid grapefruit juice.
Retard, GITS & OROS: May be taken with or without food. Avoid grapefruit juice. Swallow whole, do not chew/crush.
Adult Dose
Oral
Hypertension
Adult: Immediate-release: Initially, 5 mg tid. Maintenance: 10-20 mg tid.
Extended-release: Initially, 10-40 mg bid, or 20-90 mg once daily.
Angina pectoris
Adult: Immediate-release: Initially, 10 mg tid. Maintenance: 10-20 mg tid.
Extended-release: 10-40 mg bid or 30-60 mg once daily.
Raynaud's syndrome
Adult: Immediate-release: 5-20 mg tid.
Elderly: Dose reduction may be necessary.
Hepatic impairment: Dose reduction may be necessary.
Contraindication
Acute MI, cardiogenic shock, acute unstable angina, treatment of anginal attack in chronic stable angina.
Mode of Action
Nifedipine prevents Ca ion from entering the slow channels of cardiac and smooth muscles during depolarisation, producing peripheral and coronary vasodilatation. It reduces afterload, peripheral resistance and BP; increases coronary blood flow and causes reflex tachycardia. It has little or no effect on cardiac conduction and rarely has negative inotropic activity.
Precaution
Patients w/ hypotension, poor cardiac reserve, heart failure, severe aortic stenosis, DM, underlying severe GI narrowing (extended-release tab). Avoid abrupt withdrawal as it may casue rebound angina. Hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling Discontinue if ischaemic pain follows after admin. Monitoring Parameters Monitor BP, heart rate.
Lactation: Drug is distributed into breast milk; manufacturer suggests discontinuing drug or refraining from nursing (however, American Academy of Pediatrics states that drug is safe for nursing)
Side Effect
>10%
Peripheral edema (10-30%),Dizziness (23-27%),Flushing (23-27%),Headache (10-23%),Heartburn (11%),Nausea (11%)
1-10%
Muscle cramps (8%),Mood change (7%),Nervousness (7%),Cough (6%),Dyspnea (6%),Palpitations (6%),Wheezing (6%),Hypotension, transient (5%),Urticaria (2%),Pruritus (2%),Constipation (<2%),Chest pain (<2%)
Frequency Not Defined
Gingival hyperplasia,Agranulocytosis,Erectile dysfunction
Interaction
Enhanced antihypertensive effects w/ other antihypertensives, aldesleukin, and antipsychotics. Concomitant use w/ fentanyl during surgery caused severe hypotension. May modify insulin and glucose responses. Attenuation of tachycardic effect when used w/ benazerpril. Prothrombin time may be increased w/ coumarin anticoagulants. Increased serum levels w/ CYP3A4 inhibitors (e.g. azole antifungals, cimetidine, erythromycin, HIV-protease inhibitors, nefazodone, fluoxetine, quinupristin/dalfopristin).
Potentially Fatal: Decreased bioavailability and efficacy w/ strong CYP3A4 inducers (e.g. rifampicin, phenytoin, carbamazepine).
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