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Safety Advices
বাংলা
English
UNSAFE
Nimodi may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Nimodi may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Nimodi is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Nimodi may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Nimodi is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Nimodi may not be needed in these patients. Please consult your doctor.
CAUTION
Nimodi should be used with caution in patients with severe liver disease. Dose adjustment of Nimodi may be needed. Please consult your doctor.
Medicine Overview of Nimodi 30mg Tablet
Introduction
Nimodi is a medicine used to treat and prevent further damage to the brain after bleeding around the brain (subarachnoid hemorrhage or SAH). It is known as a calcium channel blocker and helps to improve blood flow to the brain and prevent changes in brain function. Nimodi is usually started as soon as possible after bleeding around the brain (or SAH) is confirmed by the doctor. The exact dose and frequency will be decided by your doctor depending on your medical condition and response to treatment. It may be taken empty stomach or with a meal, but take it regularly...
... Show moreUses of Nimodi
- Subarachnoid haemorrhage
Side effects of Nimodi
Common
- Decreased blood pressure
- Headache
- Increased heart rate
- Nausea
- Rash
- Stomach discomfort
- Edema (swelling)
- Muscle cramp
How to use Nimodi
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nimodi may be taken with or without food, but it is better to take it at a fixed time.
How Nimodi works
Nimodi is a calcium channel blocker. It relaxes the narrow blood vessels in the brain and makes the blood flow more easily. This prevents brain damage after bleeding around the brain.
Quick Tips
- Take it as per dose and duration suggested by your doctor.
- Do not take any antacids for 2 hours before or after taking Nimodi as it may affect the working of the medicine.
- A sudden drop in your blood pressure may occur, especially when you first start taking Nimodi. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Your doctor will monitor your blood pressure and heart rate during the treatment with this medicine.
- Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding.
Brief Description
Indication
Subarachnoid haemorrhage, Stroke prevention
Administration
Cap: Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Tab: May be taken with or without food. Take consistently, either always w/ or always w/o meals.
Adult Dose
Oral
Prophylaxis of neurological deficit following subarachnoid haemorrhage
Adult: 60 mg 4 hrly beginning w/in 4 days of onset of haemorrhage and continued for 21 consecutive days.
Hepatic impairment: Initially, 30 mg 4 hrly.
Contraindication
Use w/in 1 mth of MI or an episode of unstable angina. Concomitant use w/ potent CYP3A4 inhibitors (e.g. clarithromycin, ritonavir, ketoconazole, nefazodone).
Mode of Action
Nimodipine inhibits inflow of Ca ions into cells by blocking Ca channels or select voltage-sensitive areas resulting in relaxation of vascular smooth muscle and myocardium during depolarisation. Nimodipine has greater action on the cerebral vessels because of its high lipophilicity.
Precaution
Patients w/ cerebral oedema or severely raised intracranial pressure. Contents of oral capsules should be given only by mouth or through a feeding tube. It must never be administered IV or by any other parenteral route. Hepatic and renal impairment. Pregnancy and lactation. Monitoring Parameters Careful monitoring of BP and pulse rate.
Lactation: unknown; avoid
Side Effect
1-10%
Reduction in systemic blood pressure (1-8%),Diarrhea (2-4%),Headache (1-4%),Abdominal discomfort (2%),Rash (1-2%)
<1%
Heart failure,Arrhythmia,Anemia,ECG abnormalities,GI hemorrhage,Hepatitis,Jaundice,Thrombocytopenia,Vomiting,Thrombosis,Rebound vasospasm
Potentially Fatal: Angina/MI, symptomatic hypotension.
Interaction
Plasma concentration and efficacy may be significantly reduced when administered w/ strong CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenobarbital, phenytoin). May increase serum levels and toxicity of phenytoin. Increased plasma concentrations w/ cimetidine or sodium valproate.
Potentially Fatal: Increased risk of significant hypotension w/ concomitant potent CYP3A4 inhibitors (e.g. clarithromycin, ritonavir, ketoconazole, nefazodone).
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