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Apagrel
Healthcare Pharmaceuticals Ltd.
Generic: Prasugrel
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Apagrel does not cause any harmful side effects.
SAFE IF PRESCRIBED
Apagrel is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Apagrel is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Apagrel does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Apagrel is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Apagrel may not be needed in these patients. Please consult your doctor.
CAUTION
Apagrel should be used with caution in patients with severe liver disease. Dose adjustment of Apagrel may be needed. Please consult your doctor.
Limited information is available on the use of Apagrel in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
Medicine Overview of Apagrel 10mg Tablet
Introduction
Apagrel belongs to a group of medicines called antiplatelets or blood thinners. It helps prevent the formation of harmful blood clots and keeps the blood flowing smoothly through your body. This lowers the chances of another heart attack or stroke in people with heart disease. Apagrel is used to treat people with a recent heart attack or severe heart-related chest pain (unstable angina), who have undergone stenting of the heart. It helps to prevent serious heart-related problems like having another heart attack, stroke, or formation of blood clots in stents. Your doctor will also prescribe aspirin, another antiplatelet medicine, along...
... Show moreUses of Apagrel
- Prevention of heart attack and stroke
- Heart attack
Side effects of Apagrel
Common
- Bleeding
How to use Apagrel
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Apagrel may be taken with or without food, but it is better to take it at a fixed time.
How Apagrel works
Apagrel is an antiplatelet medication. It works by preventing platelets from sticking together, thereby decreasing the formation of harmful blood clots. This lowers the chances of another heart attack or stroke.
What if you forget to take Apagrel?
If you miss a dose of Apagrel, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- For best results, take it at the same time every day.
- Apagrel increases your risk of bleeding. Be careful while shaving, using sharp objects, or cutting fingernails or toenails.
- Do not discontinue using the medicine without consulting your doctor as this may increase your chances of having another heart attack or stroke.
- If you are scheduled to undergo a surgery or dental treatment, you may be asked to stop taking Apagrel temporarily.
Brief Description
Indication
Acute coronary syndromes, thrombotic cardiovascular (CV) events, stent thrombosis, unstable angina (UA), non-ST-elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI), Stroke
Administration
May be taken with or without food.
Adult Dose
Oral
Acute coronary syndrome
Adult: 60 mg as loading dose, followed by 10 mg once daily for up to 12 mth, given in combination w/ aspirin.
Elderly: >75 yr Maintenance: 5 mg once daily.
Patient w/ low body wt (<60 kg): 5 mg once daily as maintenance dose.
Hepatic impairment: Severe (Child-Pugh class C): Contraindicated.
Renal Dose
Renal impairment
Dose adjustment not necessary
Contraindication
Active pathological bleeding such as peptic ulcer or intracranial hamorrhage. Patient with a history of prior transient ischemic attack or stroke
Mode of Action
Prasugrel is a prodrug that inhibits platelet activation and aggregation. The active metabolite irreversibly blocks the P2Y12 component of adenosine diphosphate (ADP) receptors on the platelet, which prevents activation of the GPIIb/IIIa receptor complex, thereby reducing platelet activation and aggregation.
Precaution
Patient w/ propensity to bleed, low body wt (75 yr). Pregnancy and lactation. Monitoring Parameters Monitor Hb and haematocrit periodically; may consider platelet function testing.
Side Effect
1-10%
Bleeding,Anemia,Atrial fibrillation,Back pain,Bradycardia,Dizziness,Dyspnea,Headache,Hypertension,Nausea
<1%
Thrombotic thrombocytopenic purpura,Abnormal hepatic function,Angioedema,Hematoma,Hemolysis,Hemorrhage,Abnormal liver function
Interaction
Increased risk of bleeding w/ oral anticoagulants (e.g. warfain), clopidogrel, NSAIDs and fibrinolytics.
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