12-24 Hours
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Nortin 25
Navana Pharmaceuticals Ltd.
Generic: Nortriptyline
Safety Advices
বাংলা
English
UNSAFE
Nortin 25 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Nortin 25 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Nortin 25 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Nortin 25 may cause side effects which could affect your ability to drive.
As Nortin 25 may affect your alertness which may affect your ability to drive.
CAUTION
Nortin 25 should be used with caution in patients with kidney disease. Dose adjustment of Nortin 25 may be needed. Please consult your doctor.
CAUTION
Nortin 25 should be used with caution in patients with liver disease. Dose adjustment of Nortin 25 may be needed. Please consult your doctor.
Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine. Use of Nortin 25 is not recommended in patients with severe liver disease.
Medicine Overview of Nortin 25mg Capsule
Introduction
Nortin 25 is known as a tricyclic antidepressant. It is used to treat depression and night time bedwetting (nocturnal enuresis) by older children at different doses. Additionally, it may also be prescribed for neuropathic pain. Nortin 25 works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood. It is better to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. The dose and duration will be decided by your...
... Show moreUses of Nortin 25
- Depression
- Bed-wetting
Side effects of Nortin 25
Common
- Increased heart rate
- Weight gain
- Difficulty in urination
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Dryness in mouth
- Constipation
How to use Nortin 25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nortin 25 may be taken with or without food, but it is better to take it at a fixed time.
How Nortin 25 works
Nortin 25 is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.
What if you forget to take Nortin 25?
If you miss a dose of Nortin 25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Nortin 25 is used for the treatment of depression and bedwetting in children.
- The main dose should be taken at night as this drug may cause drowsiness or sleepiness.
- You may be asked for regular blood tests to monitor the blood cell count or level of sodium and sugar in the blood.
- Inform your doctor if you notice behavioral changes, mood changes and suicidal thoughts while taking this medicine.
- Do not drive or do anything that requires concentration until you know how the medicine affects you.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Depression, Nocturnal enuresis
Administration
May be taken with or without food.
Adult Dose
Oral
Depression
Adult: 75-100 mg/day in 3 or 4 divided doses. Max: 150 mg/day in severe depression.
Elderly: 30-50 mg/day in divided doses.
Hepatic impairment: Administer lower dose and titrate at a slower rate
Child Dose
Oral
Depression
Child: Adolescent: 30-50 mg/day in divided doses.
Nocturnal enuresis
Child: 6-7 yr (20-25 kg): 10 mg;
8-11 yr (25-35kg): 10-20 mg;
>11 yr (35-54 kg): 25-35 mg.
All doses are given 30 minutes before bedtime and treatment should continue for not >3 mth.
Contraindication
Mania, recent MI, arrhythmias (particularly heart block); severe liver disease; children <6 yr.
Mode of Action
Nortriptyline, a dibenzocycloheptadiene tricyclic antidepressant, is the primary active metabolite of amitriptyline. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.
Precaution
Not intended for treatment of bipolar depression. Avoid abrupt withdrawal. Patient at risk of seizures, w/ DM, narrow angle glaucoma, urinary retention, prostatic hyperplasia, chronic constipation, history of CV disease. Renal and hepatic impairment. Elderly, childn. Pregnancy and lactation. Patient Counselling May impair ability to perform tasks requiring mental and physical alertness (e.g. driving or operating machinery). Monitoring Parameters Monitor BP and pulse rate prior to or during initial therapy, wt. Monitor for emergence of serotonin syndrome. Closely monitor for clinical worsening, suicidality and unusual changes in behaviour. Lactation: Excreted in breast milk; do not nurse (AAP states effect on...
... Show moreSide Effect
Hypotension, HTN, tachycardia, palpitation, MI, arrhythmias, heart block, stroke; confusional states w/ hallucinations, disorientation, delusions; anxiety, restlessness, agitation; insomnia, panic, nightmares; hypomania; exacerbation of psychosis; suicidal ideation and behaviours; numbness, tingling, paraesthesia; incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms; seizures; tinnitus, dry mouth, blurred vision, accommodation disturbances, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract. Rash, itching, urticaria, photosensitisation; oedema (general or of face and tongue); bone-marrow depression including agranulocytosis, aplastic anaemia, eosinophilia, thrombocytopenia. Nausea, vomiting, anorexia, epigastric distress, diarrhoea, peculiar taste, stomatitis, abdominal cramps, malaise, jaundice, hepatitis and liver necrosis. Sweating, flushing, urinary frequency,...
... Show moreInteraction
Increased risk of serotonin syndrome w/ SSRIs, SNRIs, TCAs, triptans, fentanyl, lithium, tramadol, tryptophan, buspirone. May reduce antihypertensive effect of bethanidine, guanethidine, debrisoquine, clonidine. May increase metabolism w/ barbiturates. Increased risk of arrhythmias and hypotension w/ anaesth. Increased plasma level w/ fluoxetine.
Potentially Fatal: Increased risk of serotonin syndrome w/ MAOIs, linezolid and methylene blue.
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