12-24 Hours
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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Oflacin 400.
CONSULT YOUR DOCTOR
Oflacin 400 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Oflacin 400 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Oflacin 400 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Oflacin 400 should be used with caution in patients with kidney disease. Dose adjustment of Oflacin 400 may be needed. Please consult your doctor.
CAUTION
Oflacin 400 should be used with caution in patients with liver disease. Dose adjustment of Oflacin 400 may be needed. Please consult your doctor.
Medicine Overview of Oflacin 400mg Tablet
Introduction
Oflacin 400 is an antibiotic, used in the treatment of bacterial infections. It is also used in treating infections of the urinary tract, nose, throat, skin and soft tissues and lungs (pneumonia). It cures the infection by stopping the further growth of the causative microorganisms. Oflacin 400 should be used in the dose and duration as advised by your doctor. It may be taken with or without food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a...
... Show moreUses of Oflacin 400
- Bacterial infections
Side effects of Oflacin 400
Common
- Nausea
- Stomach pain
- Diarrhea
How to use Oflacin 400
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Oflacin 400 may be taken with or without food, but it is better to take it at a fixed time.
How Oflacin 400 works
Oflacin 400 is an antibiotic. It works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.
What if you forget to take Oflacin 400?
If you miss a dose of Oflacin 400, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Oflacin 400 to cure your infection and improve symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Discontinue Oflacin 400 and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Brief Description
Indication
Leprosy, chronic bronchitis, Community-acquired pneumonia, Uncomplicated skin infections, anthrax, Legionnaire's disease, Nongonococcal cervicitis, Urethritis, Uncomplicated cystitis, Complicated UTI, Traveller's diarrhea, bacterial prostatis, Typhoid fever, Skin and soft tissue infections, Uncomplicated gonorrhea, Pelvic inflammatory disease, Lower respiratory tract infections, Septicaemia
Administration
May be taken with or without food. Avoid antacids or supplements containing Fe or Znor or dairy products w/in 2 hr before or after ofloxacin.
Ensure adequate hydration.
Adult Dose
Oral Bronchitis Exacerbation, Community Acquired Pneumonia, Skin & Skin Structure Infections Adult: 400 mg bid for 10 days. Uncomplicated gonorrhoea Adult: 400 mg as a single dose. Nongonococcal Cervicitis/Urethritis Adult: 400 mg daily in single or divided doses for 7 days. Uncomplicated Cystitis Adult: 200 mg bid for 3-7 days. Complicated UTIs Adult: 200 mg bid for 10 days. Pelvic inflammatory disease Adult: 400 mg bid for 10-14 days. Prostatitis Adult: Acute or chronic: 200 mg bid for 28 days. Intravenous Complicated urinary tract infections Adult: 200 mg daily by infusion over at least 30 min. Max: 400 mg bid...
... Show moreChild Dose
Not indicated
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half 24 hrly following usual initial dose.
<20 and patients on haemodialysis or peritoneal dialysis 100 mg 24 hrly following usual initial dose..
Contraindication
Hypersensitivity to quinolones; pregnancy and lactation; prolongation of the QT interval; uncorrected hypokalaemia.
Mode of Action
Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms.
Precaution
Epilepsy or other predisposition to seizures; known or suspected CNS disorders; renal, hepatic impairment; myasthaenia gravis; superinfection; children <18 yr; exposure to strong sunlight and UV light; ensure adequate hydration; elderly.
Lactation: excreted in breast milk, discontinue drug or do not nurse
Side Effect
1-10%
Nausea (3-10%),Headache (1-9%),Insomnia (3-7%),Dizziness (1-5%),Vaginitis (1-5%),Diarrhea (1-4%),Vomiting (1-4%),Appetite decreased (1-3%),Abdominal cramps (1-3%),Abnormal taste (1-3%),Chest pain (1-3%),External genital pruritis in women (1-3%),Fatigue (1-3%),Flatulence (1-3%),GI distress (1-3%),Nervousness (1-3%),Pharyngitis (1-3%),Pyrexia (1-3%),Rash/pruritis (1-3%),Sleep disorders (1-3%),Visual disturbances (1-3%),Xerostomia (1-3%)
<1%
Prolonged QT interval,Torsades de pointes,Syncope,Vasculitis,Edema,HTN,Palpitations,Vasodilation,Stevens-Johnson syndrome,Toxic epidermal necrolysis,Agranulocytosis,Aplastic anemia,Pancytopenia,Thrombocytopenia,Thrombocytopenic purpura,Acute hepatitis,Hepatic failure,Hepatic necrosiImmune hypersensitivity reaction,Rupture of tendon, Tendinitis,Peripheral neuropathy,Seizure,Acute renal failure,Interstitial nephritis,Renal impairment,Tourette's syndrome,Decrease hearing acuity,Tinnitus
Potentially Fatal: Anaphylaxis; rarely seizures.
Interaction
Concomitant use of class IA (e.g. quinidine, procainamide) or class III (e.g. amiodarone, sotalol) antiarrhythmic agents may increase risk of QT interval prolongation. Decreased serum and urine concentrations w/ antacids containing Mg, Al or Ca. Additive antibacterial activity w/ aminoglycosides (e.g. amikacin, tobramycin). Corticosteroids may increase risk of severe tendon disorders. Increased risk of CNS stimulation (e.g. seizures) w/ NSAIDs. Higher and prolonged serum theophylline concentrations and increased risk of theophylline-related adverse effects.
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