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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Apilast. Please consult your doctor.
CONSULT YOUR DOCTOR
Apilast may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Apilast during breastfeeding is not available. Please consult your doctor.
SAFE
Apilast does not usually affect your ability to drive.
CAUTION
Apilast should be used with caution in patients with severe kidney disease. Dose adjustment of Apilast may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Apilast is safe to use in patients with liver disease. No dose adjustment of Apilast is recommended.
Medicine Overview of Apilast 10mg Tablet
Introduction
Apilast is used in the treatment of moderate to severe plaque psoriasis which is a type of skin condition. This medicine is used when other conventional treatments cannot be used or if the patient is not responsive or intolerant to any of these treatments. Apilast can be taken with or without food. Take it regularly and do not stop taking the medicine even if you get better until that doctor tells you it is alright to stop. You may need to monitor your weight regularly while taking the medicine as it may cause weight loss. Using this medicine may cause...
... Show moreUses of Apilast
- Plaque psoriasis
Side effects of Apilast
Common
- Diarrhea
- Nausea
- Vomiting
How to use Apilast
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Apilast may be taken with or without food, but it is better to take it at a fixed time.
How Apilast works
Apilast is a phosphodiesterase 4 (PDE4) inhibitors. It works by blocking the action of certain chemical messengers that are responsible for inflammation associated with psoriatic arthritis and psoriasis, and thereby reduces the signs and symptoms of these conditions.
Quick Tips
- Apilast is a well-tolerated medicine. Mild stomach upset may occur early during the treatment.
- Monitor your weight regularly as Apilast may cause weight loss.
- Your doctor will gradually increase the dose from day 1 to day 6 of treatment, after which it may be kept constant.
- Tell your doctor immediately if you experience new or worsened depression, suicidal thoughts, other mood changes or unexplained weight loss.
Brief Description
Indication
Active psoriatic arthritis, moderate to severe plaque psoriasis
Administration
To reduce risk of GI symptoms associated with initial therapy, titrate to recommended dose (30 mg PO BID) according to the dosage schedules listed above
Can be administered without regard to meals
Swallow tablet whole; do not crush, split, or chew
Adult Dose
Active psoriatic arthritis, moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.
To reduce risk of gastrointestinal symptoms, titrate to recommended dose of 30 mg twice daily according to the following schedule:
Day 1: 10 mg in morning
Day 2: 10 mg in morning and 10 mg in evening
Day 3: 10 mg in morning and 20 mg in evening
Day 4: 20 mg in morning and 20 mg in evening
Day 5: 20 mg in morning and 30 mg in evening
Day 6 and thereafter: 30 mg twice daily
Hepatic impairment: No dosage adjustment required
Renal Dose
Severe renal impairment (CrCl <30 mL/min): Reduce dose to 30 mg PO qDay
Mild-to-moderate renal impairment: No dosage adjustment required
Contraindication
Known hypersensitivity to apremilast.
Mode of Action
Apremilast is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels. The specific mechanism(s) by which apremilast exerts its therapeutic action in psoriatic arthritis patients and psoriasis patients is not well defined.
Precaution
Apremilast is associated with an increase in adverse reactions of depression. Before using, evaluate patient for history of depression and/or suicidal thoughts or behavior.
Weight decrease of 5-10% of body weight. Monitor weight regularly. If unexplained or clinically significant weight loss occurs, evaluate weight loss and consider discontinuation of Apremilast.
Lactation: Unknown if distributed in human breast milk; caution required
Side Effect
1-10%
Diarrhea (7.7-9.3%),Nausea (7.4-8.9%),Headache (4.8-5.9%),Upper respiratory tract infection (0.6-3.9%),Vomiting (0.8-3.2%),Nasopharyngitis (0.2-2.6%),Upper abdominal pain (0.6-2%)
Pregnancy Category Note
Pregnancy Available pharmacovigilance data use in pregnant women have not established a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes, but data are extremely limited Based on findings from animal reproduction studies, may increase the risk for fetal loss Lactation There are no data on the presence of apremilast in human milk, the effects on the breastfed infant, or the effects on milk production Detected in the milk of lactating mice Consider developmental and health benefits of breastfeeding along with the mother’s clinical need and any potential adverse effects on the breastfed infant or from...
... Show moreInteraction
Coadministration with strong CYP inducers (eg, rifampin, carbamazepine, phenobarbital phenytoin) may occur and result in a loss of efficacy of apremilast; therefore, coadministration is not recommended.
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