12-24 Hours
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Orocal Kit
Ziska Pharmaceuticals Ltd.
Generic: Ibandronic acid+ Calcium Orotate
Medicine Overview of Orocal Kit 150mg+400mg Tablet
বাংলা
English
Indication
Treatment & Prevention of Osteoporosis in women after menopause
Administration
To maximize absorption and clinical benefit, Ibandronic acid should be taken at least 60 minutes before the first food or drink (other than water) of the day or before taking any oral medication or supplementation, including calcium, antacids, or vitamins. Ibandronic acid tablets should be swallowed whole with a full glass of plain water (6 to 8 oz) while the patient is standing or sitting in an upright position. Patients should not lie down for 60 minutes after taking Ibandronic acid. Patients should not eat, drink anything except water, or take other medications for at least 60 minutes after taking...
... Show moreAdult Dose
1 tablet of ibandronic acid 150 mg once monthly on the same date of each month is recommended.
To maximize clinical benefit of ibandronic acid 2 tablets of Calcium Orotate 400mg per day usually recommended in divided dosage.
Contraindication
Ibandronic acid:
Abnormalities of the esophagus, which delay esophageal emptying
Inability to stand or sit upright for at least 60 minutes
Hypocalcaemia
Known hypersensitivity to Ibandronic acid or to any of its excipients
Calcium orotate:
Kidney stone
Kidney disease
Sarcoidosis
Increased activity of the parathyroid gland
High amount of calcium in urine
High amount of calcium in the blood
Extreme loss of body water
Mode of Action
Ibandronic Acid (Ibandronate Sodium Monohydrate) is a nitrogen-containing bisphosphonate that inhibits osteoclast-mediated bone resorption. The action of Ibandronate on bone tissue is based on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Ibandronate inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass. Calcium Orotate, a calcium supplement with a functional amino acid chelating ligand - orotic acid. Orotic acid assists the transport of calcium through cellular membrane structures, facilitating the intracellular uptake of calcium,...
... Show morePrecaution
Ibandronic acid: Upper Gastrointestinal Adverse Reactions: Ibandronic acid like other bisphosphonates administered orally may cause local irritation of the upper gastrointestinal mucosa. Because of these possible irritant effects, caution should be used when Ibandronic acid is given to patients with active upper gastrointestinal problems (such as known Barrett’s esophagus, dysphagia, other esophageal diseases, gastritis, duodenitis or ulcers). Hypocalcaemia and Mineral Metabolism: Treat hypocalcemia and other disturbances of bone and mineral metabolism before starting therapy. Musculoskeletal Pain: Severe and occasionally incapacitating bone, joint, and/or muscle pain has been reported in patients taking Ibandronic acid and other bisphosphonates. Jaw Osteonecrosis: Osteonecrosis, primarily...
... Show moreSide Effect
Ibandronic acid:
Flu-like symptoms (e.g. myalgia, arthralgia, fever, chills, fatigue, nausea, loss of appetite, bone pain), atypical fractures, osteonecrosis of the jaw, ocular inflammation, acute renal failure, hypocalcaemia, musculoskeletal pain. Rarely, anaemia, bronchospasm, taste disturbance, paraesthesia, uraemia; transient fever (IV); abdominal pain, dyspepsia, severe oesophageal reactions (oral).)
Potentially Fatal: Anaphylactic reaction/shock.
Calcium orotate:
Bloating and swelling in the abdomen are common side effects of Calcium Orotate. Constipation, nausea, vomiting, headache, increased thirst/urination, may occur infrequently.
Interaction
Ibandronic Acid: Products containing calcium and other multivalent cations (such as Aluminum, Magnesium, Iron etc.), including milk, food, and antacids are likely to interfere with absorption of ibandronate. It is also found to interact with H2 blockers such as Ranitidine in several clinical trials.
Calcium can decrease absorption of the following drugs when taken together- biphosphonates (e.g. alendronates), quinolone antibiotics (e.g. ciprofloxacin, levofloxacin) and tetracycline antibiotics (e.g. doxycycline, minocycline), levothyroxine, phenytoin (anticonvulsant), and tiludronate disodium (to treat Paget's disease). Thiazide-type diuretics can interact with calcium supplements, increasing the risks of hypercalcemia and hypercalciuria.
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