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Arbitain Plus 75
Opsonin Pharma Limited
Generic: Hydrochlorothiazide + Irbesartan
Safety Advices
বাংলা
English
UNSAFE
Arbitain Plus 75 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Arbitain Plus 75 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Arbitain Plus 75 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Arbitain Plus 75 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Arbitain Plus 75 should be used with caution in patients with severe kidney disease. Dose adjustment of Arbitain Plus 75 may be needed. Please consult your doctor.
Use of Arbitain Plus 75 is not recommended in patients with severe kidney disease.
CAUTION
Arbitain Plus 75 should be used with caution in patients with liver disease. Dose adjustment of Arbitain Plus 75 may be needed. Please consult your doctor.
Medicine Overview of Arbitain Plus 75 12.5mg+75mg Tablet
Introduction
Arbitain Plus 75 is a combination of two medicines. It helps to control high blood pressure in different ways. If high blood pressure is not treated it can lead to heart attacks, strokes and kidney failure. You can take Arbitain Plus 75 with or without food. The dose will depend on your condition and how your respond to the medicine. Try to take it at the same time each day. It is important to keep taking this medicine until your doctor tells you not to. It contains a diuretic (water pill) and will make you urinate more so, it is...
... Show moreUses of Arbitain Plus 75
- Hypertension (high blood pressure)
Side effects of Arbitain Plus 75
Common
- Nausea
- Taste change
- Upset stomach
- Diarrhea
- Weakness
- Dizziness
- Headache
- Glucose intolerance
- Increased blood uric acid
- Increased blood lipid level
- Electrolyte imbalance
- Decreased blood pressure
How to use Arbitain Plus 75
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Arbitain Plus 75 may be taken with or without food, but it is better to take it at a fixed time.
How Arbitain Plus 75 works
Arbitain Plus 75 is a combination of two medicines: Irbesartan and hydrochlorothiazide which lower blood pressure effectively. Irbesartan is an angiotensin receptor blocker (ARB). It works by blocking the hormone angiotensin thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Hydrochlorothiazide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Quick Tips
- You have been prescribed Arbitain Plus 75 for the treatment of high blood pressure.
- It can be taken with or without food.
- Arbitain Plus 75 may cause dehydration. Drink plenty of fluids and inform your doctor if you develop extreme thirst, very dry mouth or muscle weakness.
- It may cause dizziness. Get up slowly when rising from a sitting or lying position.
- Use of Arbitain Plus 75 during pregnancy or breastfeeding is unsafe.
- It may also decrease the risk of stroke and heart attacks.
Brief Description
Indication
Diabetic nephropathy, Hypertension
Adult Dose
Hypertension
150 mg/12.5 mg PO qDay intially; if needed, after 1-2 weeks may titrate up to 300 mg/25 mg PO qDay
Contraindication
Hypersensitivity; pregnancy and lactation.
Mode of Action
Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions.
Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors.
Precaution
Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy.
Lactation: discontinue drug or do not nurse
Side Effect
>10%
Irbesartan
Hyperkalemia (19%)
1-10%
Chest pain (2%),Tachycardia (1%),Abnormal urination (2%),Musculoskeletal pain (6%),Flu-like syndrome (3%),Edema (3%),Tachycardia (1%),Chest pain (2%),Creatinine increased (1%),Increased BUN (2%)
Irbesartan
Dizziness (10%),URI (9%),Orthostatic hypotension (5%),Fatigue (4%),Diarrhea (3%),Dyspepsia (2%)
Frequency Not Defined
Hydrochlorothiazide
Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Hypokalemia and/or hypomagnesemia,Hyperuricemia,Headache
Pregnancy Category Note
Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters)
Interaction
Other antihypertensives, lithium, K-sparing diuretics, K supplements, salt substitutes containing K. CNS depressants, antidiabetics, cholestyramine & colestipol resins, corticosteroids, ACTH, digitalis glycosides, antiarrhythmics, NSAIDs, tubocurarine, antigout medications, Ca salts. Alcohol; ?-blockers, diazoxide, atropine, beperiden, amantadine, cyclophosphamide, methotrexate.
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