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Oxiplat-50
Drug International Ltd.
Generic: Oxaliplatin
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Oxiplat-50. Please consult your doctor.
CONSULT YOUR DOCTOR
Oxiplat-50 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Oxiplat-50 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Oxiplat-50 may cause side effects which could affect your ability to drive.
Oxaliplatin_name$ treatment may result in an increased risk of dizziness, nausea, and vomiting, and other neurological symptoms that affect walking and this may affect your ability to drive.
CAUTION
Oxiplat-50 should be used with caution in patients with severe kidney disease. Dose adjustment of Oxiplat-50 may be needed. Please consult your doctor.
Limited information is available on the use of Oxiplat-50 in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
CAUTION
Oxiplat-50 should be used with caution in patients with liver disease. Dose adjustment of Oxiplat-50 may be needed. Please consult your doctor.
Medicine Overview of Oxiplat-50mg/vial Infusion
Introduction
Oxiplat-50 is used in the treatment of cancer of colon and rectum. It shows its working by stopping or slowing down the growth of cancer cells. Oxiplat-50 is given as an injection into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may...
... Show moreUses of Oxiplat-50
- Cancer of colon and rectum
Side effects of Oxiplat-50
Common
- Nausea
- Fatigue
- Anemia (low number of red blood cells)
- Vomiting
- Diarrhea
- Decreased white blood cell count (neutrophils)
- Low blood platelets
- Increased liver enzymes
- Peripheral neuropathy (tingling and numbness of feet and hand)
- Stomatitis (Inflammation of the mouth)
How to use Oxiplat-50
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Oxiplat-50 works
Oxiplat-50 is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth and multiplication.
What if you forget to take Oxiplat-50?
If you miss a dose of Oxiplat-50, please consult your doctor.
Quick Tips
- Oxiplat-50 is given as an injection into veins under the supervision of a doctor.
Brief Description
Indication
Colorectal cancer, Colon cancer
Administration
IV Preparation
Reconstitute by adding 10 mL (for 50 mg vial) or 20 mL (for 100 mg vial) of SWI or D5W. Dilute required amount of reconstituted solution in an infusion solution of 250-500 mL of D5W. Do NOT use NS or chloride-containing solutions
Do not use aluminum-containing needles or IV administration sets that may come in contact with carboplatin (aluminum can react causing precipitate formation and loss of potency)
IV Administration
Flush infusion line with D5W prior to administration of oxaliplatin or any concomitant drug
Use separate bags for oxaliplatin and leucovorin (administered through Y-site)
Adult Dose
Intravenous Advanced colorectal cancer Adult: Day 1: Oxaliplatin 85 mg/m² IV + leucovorin 200 mg/m² IV infused over 2 hr, THEN 5-FU 400 mg/m² IV bolus over 2-4 minutes, THEN 5-FU 600 mg/m² IV infusion in D5W (500 mL) over 22 hr Day 2: Same regimen WITHOUT oxaliplatin Repeat every 2 weeks Adjuvant therapy in stage III colon cancer Adult: Day 1: Oxaliplatin 85 mg/m² IV + leucovorin 200 mg/m² IV infused over 2 hr, THEN 5-FU 400 mg/m² IV bolus over 2-4 minutes, THEN 5-FU 600 mg/m² IV infusion in D5W (500 mL) over 22 hr Day 2: Same...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Renal Impairment
Exposure of unbound platinum tends to increase in renally impaired patients
Mild (CrCl 50-80 mL/min): No dosage adjustment required
Moderate (CrCl 30-49 mL/min): No dosage adjustment required
Severe (CrCl <30 mL/min): Reduce starting dose
Contraindication
Pregnancy. Peripheral neuropathy with functional impairment. Severe renal impairment.
Mode of Action
Oxaliplatin, a platinum-containing complex similar to cisplatin, is an alkylating agent. After intracellular hydrolysis, the platinum compound binds to DNA forming cross-links which inhibit DNA replication and transcription, resulting in cell death.
Precaution
Should be administered under the supervision of an experienced cancer chemotherapy physician. Use appropriate precautions for handling and disposal. Monitor neurological status and dose should be reduced if symptoms are prolonged or severe. Monitor blood counts during treatment and courses should not be repeated until blood counts have recovered. Caution in elderly, moderate degrees of renal impairment. Avoid using aluminum-containing needles or IV admin sets that may come into contact with oxaliplatin as aluminum has been reported to cause degradation of platinum compounds. Lactation.
Lactation: not known if excreted in milk
Side Effect
>10%
Peripheral neuropathy (76%),Anemia (64%),Nausea (64%),Fatigue (61%),Diarrhea (46%),Vomiting (37%),Abdominal pain (31%),Constipation (31%),Thrombocytopenia (30%),Fever (25%),Anorexia (20%),Leukopenia (13%),Dyspnea (13%),Cough (11%)
1-10%
Edema (10%),Neutropenia (7%),Pharyngolaryngeal dysesthesia (1-2%)
<1%
Pulmonary fibrosis,Posterior leukoencephalopathy syndrome
Frequency Not Defined
Anaphylactic-like reaction (uncommon),Pulmonary fibrosis (uncommon)
Potentially Fatal: Anaphylaxis, pulmonary fibrosis.
Interaction
May decrease plasma levels of digoxin. May increase risk of toxicity with nephrotoxic drugs. When administered as sequential infusions, taxane derivatives (docetaxel, paclitaxel) should be administered before oxaliplatin to limit myelosuppression and enhance efficacy.
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