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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with P Phos.
CONSULT YOUR DOCTOR
P Phos is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
P Phos is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
P Phos may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CONSULT YOUR DOCTOR
There is limited information available on the use of P Phos in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of P Phos in patients with liver disease. Please consult your doctor.
Medicine Overview of P Phos 15mg Tablet
Introduction
P Phos is an antiparasitic medicine, used for the prevention and treatment of malaria. It works by killing malaria causing parasite and stops the infection from spreading. P Phos should be used in the dose and duration as advised by your doctor. Take it with food to decrease the risk of stomach upset. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Do not take a double dose to make up for a missed dose. Simply take the...
... Show moreUses of P Phos
- Malaria
Side effects of P Phos
Common
- Rash
- Vomiting
- Headache
- Dizziness
- Hives
- Stomach pain
- Nausea
- Abdominal pain
- Itching
- Heartburn
- Gastrointestinal discomfort
- Upper abdominal pain
How to use P Phos
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. P Phos is to be taken with food.
How P Phos works
P Phos is a an antiparasitic medication which treats malaria. It works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading.
Quick Tips
- P Phos is used for the prevention and treatment of malaria.
- Take it with food to decrease the risk of stomach upset.
- Tips to reduce the chance of being bitten by mosquitoes:
- It may cause blurring of vision, when you first start taking it. Use caution while driving or doing anything that requires concentration.
- Eye examination prior to and at 3–6 monthly intervals during use is required if patients are receiving P Phos at continuous high doses for longer duration.
- It may cause low blood sugar level. Monitor your blood sugar level regularly, if you are diabetic.
- When used long term, your doctor may monitor the amounts of the different types of blood cells in your blood regularly. Inform your doctor if you have unexplained bruising or bleeding, sore throat, fever, or general feeling of tiredness.
Brief Description
Indication
Malaria
Administration
Should be taken with food. Take w/ meals to avoid GI discomfort.
Adult Dose
Oral
Prevention of relapse of P. vivax malaria
30 mg PO qDay for 14 days
Uncomplicated P. vivax and P. ovale malaria
30 mg PO qDay for 14 days with chloroquine or hydroxychloroquine
Alternatively, for mild G6PD deficiency or as alternative to daily regimen: 45 mg PO qDay for 8 weeks (only to be used after consultation with an infectious disease/tropical medicine expert
Chemoprophylaxis
P. vivax and P. ovale maleria: 30 mg PO qDay for 14 days after departure from malaria-endemic area
Child Dose
Oral
Uncomplicated P. vivax and P. ovale malaria
0.5 mg/kg (30 mg/day maximum) qDay for 14 days with chloroquine or hydroxychloroquine
Chemoprophylaxis
0.5 mg/kg PO qDay (30 mg/day maximum); start 1-2 days prior to travel and continue for 7 days after departure from malaria endemic area
Contraindication
Hypersensitivity. Childn <1 yr. Acute flare-ups of systemic diseases (RA, SLE) having tendency for agranulocytopaenia, Pregnancy and lactation.
Mode of Action
Primaquine is an 8-aminoquinoline antimalarial which eliminates the exoerythrocytic forms of malarial parasite P.vivax, P. falciparum by disrupting mitochondria and binding to DNA. By this action primaquine achieves radical cure of vivax malaria. It is also active against gametocytes of P.falciparum.
Precaution
G6PD deficiency; pregnancy; NADH methaemoglobin reductase deficient patients. Monitor Hb levels and blood counts routinely. Patients with systemic diseases that have an increased risk of granulocytopenia. Withdraw treatment if signs of haemolysis or methaemogloinaemia occur.
Side Effect
>10%
Abdominal pain,Hemolytic anemia in G6PD deficiency,Nausea,Vomiting
<1-10%
Methemoglobinemia in NADH-methemoglobin reductase-deficient individuals
<1%
Agranulocytosis,Arrhythmias,Headache,Interference with visual accommodation,Leukopenia,Leukocytosis,Rash,Dizziness,Pruritus
Potentially Fatal: Haemolytic anaemia (G6PD deficient), thrombocytopaenia, leucopaenia, AV block.
Interaction
Primaquine may inhibit metabolism of chloroquine. Avoid ethanol.
Potentially Fatal: Mepacrine may potentiate toxicity of primaquine. Potentially haemolytic drugs eg, sulphonamides, nitrofurans and bone marrow suppressants eg, methotrexate, phenylbutazone, chloramphenicol should not be co-admin with primaquine.
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